Evaluation of clinical and histomorphological parameters as potential predictors of occult metastases in sentinel lymph nodes of early squamous cell carcinoma of the oral cavity

Annals of Surgical Oncology

Volumn 17, Issue 2, 2010, Pages 527-535

  Goerkem, Mete ^a   Braun, Julia ^b   Stoeckli, Sandro J ^a,c  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c Kantonsspital St Gallen ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER SURGERY; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CLINICAL FEATURE; CONTROLLED STUDY; EARLY CANCER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; MOUTH CARCINOMA; OCCULT CANCER; PRIMARY TUMOR; PROSPECTIVE STUDY; SENTINEL LYMPH NODE; SENTINEL LYMPH NODE BIOPSY; SQUAMOUS CELL CARCINOMA; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROSPECTIVE STUDIES; SENTINEL LYMPH NODE BIOPSY; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 77149173727     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-009-0755-3     Document Type: Article

References (48)

1. IK Kalnins AG Leonard K Sako MS Razack DP Shedd 1977 Correlation between prognosis and degree of lymph node involvement in carcinoma of the oral cavity Am J Surg 134 4 450 454 10.1016/0002-9610(77)90376-2 1:STN:280: DyaE1c%2Fhsl2jtA%3D%3D 911028 (Pubitemid 8201784)
2. DM Barrs LW De Santo WM O'Fallon 1979 Squamous cell carcinoma of the tonsil and tongue-base region Arch Otolaryngol 105 8 479 485 1:STN:280:DyaE1M3jtV2qsg%3D%3D 464887
3. CD Callery RH Spiro EW Strong 1984 Changing trends in the management of squamous carcinoma of the tongue Am J Surg 148 4 449 454 10.1016/0002-9610(84) 90368-4 1:STN:280:DyaL2M%2FitVClug%3D%3D 6486311 (Pubitemid 14012936)
4. C Grandi M Alloisio D Moglia S Podrecca L Sala P Salvatori R Molinari 1985 Prognostic significance of lymphatic spread in head and neck carcinomas: therapeutic implications Head Neck Surg 8 2 67 73 10.1002/hed.2890080202 1:STN:280:DyaL28%2FosFSqsQ%3D%3D 4077553
5. RM Byers PF Wolf AJ Ballantyne 1988 Rationale for elective modified neck dissection Head Neck Surg 10 3 160 167 10.1002/hed.2890100304 1:STN:280:DyaL1M7ntl2guw%3D%3D 3235344 (Pubitemid 19093833)
6. MW van den Brekel I van der Waal CJ Meijer JL Freeman JA Castelijns GB Snow 1996 The incidence of micrometastases in neck dissection specimens obtained from elective neck dissections Laryngoscope 106 8 987 991 10.1097/00005537- 199608000-00014 8699914
7. DN Krag DL Weaver JC Alex JT Fairbank 1993 Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe Surg Oncol 2 6 335 339 10.1016/0960-7404(93)90064-6 1:STN:280: DyaK2c7nslegtQ%3D%3D 8130940 (Pubitemid 24019852)
8. DL Morton DR Wen JH Wong JS Economou LA Cagle FK Storm, et al. 1992 Technical details of intraoperative lymphatic mapping for early stage melanoma Arch Surg 127 4 392 399 1:STN:280:DyaK383hsFWjsw%3D%3D 1558490
9. SJ Stoeckli 2007 Sentinel node biopsy for oral and oropharyngeal squamous cell carcinoma of the head and neck Laryngoscope 117 9 1539 1551 10.1097/MLG.0b013e318093ee67 17667135 (Pubitemid 47357381)
10. T Shoaib DS Soutar JE Prosser DJ Dunaway HW Gray GM McCurrach, et al. 1999 A suggested method for sentinel node biopsy in squamous cell carcinoma of the head and neck Head Neck 21 8 728 733 10.1002/(SICI)1097-0347(199912)21: 8<728::AID-HED8>3.0.CO;2-P 1:STN:280:DC%2BD3c%2FjtFOitg%3D%3D 10562686
11. GL Ross T Shoaib DS Soutar DG MacDonald IG Camilleri RG Bessent, et al. 2002 The First International Conference on Sentinel Node Biopsy in Mucosal Head and Neck Cancer and adoption of a multicenter trial protocol Ann Surg Oncol 9 4 406 410 10.1007/BF02573877 1:STN:280:DC%2BD383kslSrsQ%3D%3D 11986194
12. Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, et al. AJCC cancer staging handbook, 6th ed. New York: Springer; 2002.
13. SJ Stoeckli H Steinert M Pfaltz S Schmid 2001 Sentinel lymph node evaluation in squamous cell carcinoma of the head and neck Otolaryngol Head Neck Surg 125 3 221 226 10.1067/mhn.2001.118074 1:STN:280:DC%2BD3Mrgslahtw%3D%3D 11555757 (Pubitemid 33662671)
14. P Ambrosch M Kron G Fischer U Brinck 1995 Micrometastases in carcinoma of the upper aerodigestive tract: detection, risk of metastasizing, and prognostic value of depth of invasion Head Neck 17 6 473 479 10.1002/hed.2880170604 1:STN:280:DyaK287hsFKnsQ%3D%3D 8847205
15. SV Kane M Gupta AC Kakade A D' Cruz 2006 Depth of invasion is the most significant histological predictor of subclinical cervical lymph node metastasis in early squamous carcinomas of the oral cavity Eur J Surg Oncol 32 7 795 803 10.1016/j.ejso.2006.05.004 1:STN:280:DC%2BD28rhtV2ksw%3D%3D 16777368 (Pubitemid 44276021)
16. S Shingaki I Suzuki T Nakajima T Kawasaki 1988 Evaluation of histopathologic parameters in predicting cervical lymph node metastasis of oral and oropharyngeal carcinomas Oral Surg Oral Med Oral Pathol 66 6 683 688 10.1016/0030-4220(88)90318-0 1:STN:280:DyaL1M%2FotlWmuw%3D%3D 3205557 (Pubitemid 19019645)
17. TM Pimenta Amaral AR Da Silva Freire AL Carvalho CA Pinto LP Kowalski 2004 Predictive factors of occult metastasis and prognosis of clinical stages I and II squamous cell carcinoma of the tongue and floor of the mouth Oral Oncol 40 8 780 786 10.1016/j.oraloncology.2003.10.009 15288831 (Pubitemid 39061092)
18. M Brandwein-Gensler MS Teixeira CM Lewis B Lee L Rolnitzky JJ Hille, et al. 2005 Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival Am J Surg Pathol 29 2 167 178 10.1097/01.pas.0000149687.90710.21 15644773 (Pubitemid 40170634)
19. E Yamamoto A Miyakawa G Kohama 1984 Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity Head Neck Surg 6 5 938 947 10.1002/hed.2890060508 1:STN:280:DyaL2c3htFKqtw%3D%3D 6724960
20. H Kurokawa M Zhang S Matsumoto Y Yamashita T Tomoyose T Tanaka, et al. 2005 The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma J Oral Pathol Med 34 6 329 333 10.1111/j.1600-0714.2005.00244.x 1:STN:280:DC%2BD2MzgtV2ktw%3D%3D 15946179 (Pubitemid 40868402)
21. H Kurokawa Y Yamashita S Takeda M Zhang H Fukuyama T Takahashi 2002 Risk factors for late cervical lymph node metastases in patients with stage I or II carcinoma of the tongue Head Neck 24 8 731 736 10.1002/hed.10130 12203797 (Pubitemid 34857298)
22. JA Woolgar J Scott 1995 Prediction of cervical lymph node metastasis in squamous cell carcinoma of the tongue/floor of mouth Head Neck 17 6 463 472 10.1002/hed.2880170603 1:STN:280:DyaK287hsFKnsA%3D%3D 8847204
23. SC Lim S Zhang G Ishii Y Endoh K Kodama S Miyamoto, et al. 2004 Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue Clin Cancer Res 10 1 Pt 1 166 172 10.1158/1078-0432.CCR-0533-3 1:CAS:528:DC%2BD2cXkvF2ntQ%3D%3D 14734465 (Pubitemid 38114175)
24. B Brown L Barnes J Mazariegos F Taylor J Johnson RL Wagner 1989 Prognostic factors in mobile tongue and floor of mouth carcinoma Cancer 64 6 1195 1202 10.1002/1097-0142(19890915)64:6<1195::AID-CNCR2820640606>3.0. CO;2-7 1:STN:280:DyaL1MzlsVWlug%3D%3D 2766218
25. H Fukano H Matsuura Y Hasegawa S Nakamura 1997 Depth of invasion as a predictive factor for cervical lymph node metastasis in tongue carcinoma Head Neck 19 3 205 210 10.1002/(SICI)1097-0347(199705)19:3<205::AID-HED7>3.0. CO;2-6 1:STN:280:DyaK2s3oslChug%3D%3D 9142520
26. M Okamoto M Nishimine M Kishi T Kirita M Sugimura M Nakamura, et al. 2002 Prediction of delayed neck metastasis in patients with stage I/II squamous cell carcinoma of the tongue J Oral Pathol Med 31 4 227 233 10.1034/j.1600-0714. 2002.310406.x 12076326 (Pubitemid 34458422)
27. A Po Wing Yuen KY Lam LK Lam CM Ho A Wong TL Chow, et al. 2002 Prognostic factors of clinically stage I and II oral tongue carcinoma-A comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score, and pathologic features Head Neck 24 6 513 520 10.1002/hed.10094 12112547 (Pubitemid 34568551)
28. MA Mohit-Tabatabai HJ Sobel BF Rush A Mashberg 1986 Relation of thickness of floor of mouth stage I and II cancers to regional metastasis Am J Surg 152 4 351 353 10.1016/0002-9610(86)90303-X 1:STN:280:DyaL2s%2FitlGrtg%3D%3D 3766862 (Pubitemid 16001461)
29. A Sparano G Weinstein A Chalian M Yodul R Weber 2004 Multivariate predictors of occult neck metastasis in early oral tongue cancer Otolaryngol Head Neck Surg 131 4 472 476 10.1016/j.otohns.2004.04.008 15467620 (Pubitemid 39298215)
30. G Warburton NG Nikitakis P Roberson NJ Marinos T Wu JJ Sauk Jr, et al. 2007 Histopathological and lymphangiogenic parameters in relation to lymph node metastasis in early stage oral squamous cell carcinoma J Oral Maxillofac Surg 65 3 475 484 10.1016/j.joms.2005.12.074 17307596 (Pubitemid 46343583)
31. T Asakage T Yokose K Mukai S Tsugane Y Tsubono M Asai S Ebihara 1998 Tumor thickness predicts cervical metastasis in patients with stage I/II carcinoma of the tongue Cancer 82 8 1443 1448 10.1002/(SICI)1097-0142(19980415) 82:8<1443::AID-CNCR2>3.0.CO;2-A 1:STN:280:DyaK1c3htlWrsA%3D%3D 9554518 (Pubitemid 28164987)
32. RH Spiro AG Huvos GY Wong JD Spiro CA Gnecco EW Strong 1986 Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth Am J Surg 152 4 345 350 10.1016/0002-9610(86)90302-8 1:STN:280:DyaL2s%2FitlGrsQ%3D%3D 3766861 (Pubitemid 16001460)
33. C Martínez-Gimeno EM Rodríguez CN Vila CL Varela 1995 Squamous cell carcinoma of the oral cavity: a clinicopathologic scoring system for evaluating risk of cervical lymph node metastasis Laryngoscope 105 71 728 733 7603278
34. S Wenzel C Sagowski W Kehrl FU Metternich 2004 Retrospective analysis of the prognostic significance of depth of invasion of advanced oral and oropharyngeal squamous cell carcinomas with lymph node metastases HNO 52 7 604 610 10.1007/s00106-003-0962-3 1:STN:280:DC%2BD2cvgsVGktw%3D%3D 15309257
35. RP Morton CM Ferguson NK Lambie RM Whitlock 1994 Tumor thickness in early tongue cancer Arch Otolaryngol Head Neck Surg. 120 7 717 720 1:STN:280:DyaK2c3ovV2mtQ%3D%3D 8018323
36. MA Lopes NG Nikitakis MA Reynolds RA Ord J Sauk Jr 2002 Biomarkers predictive of lymph node metastases in oral squamous cell carcinoma J Oral Maxillofac Surg 60 2 142 147 10.1053/joms.2002.29804 11815908 (Pubitemid 34111991)
37. RM Byers AK El-Naggar YY Lee B Rao B Fornage NH Terry, et al. 1998 Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue? Head Neck 20 2 138 144 10.1002/(SICI)1097-0347(199803)20:2<138::AID-HED7>3.0.CO;2-3 1:STN:280:DyaK1c7ktlCktA%3D%3D 9484945 (Pubitemid 28106226)
38. RB Chen K Suzuki T Nomura T Nakajima 1993 Flow cytometric analysis of squamous cell carcinomas of the oral cavity in relation to lymph node metastasis J Oral Maxillofac Surg 51 4 397 401 1:STN:280:DyaK3s7psFKjtg%3D%3D 8450358
39. T Osaki J Hirota K Yoneda T Yamamoto E Ueta 1996 Clinical and histopathologic characteristics of tongue and gingiva carcinomas with occult and clinically evident cervical lymph-node metastasis Int J Oral Maxillofac Surg 25 4 274 278 10.1016/S0901-5027(06)80055-X 1:STN:280:DyaK2s%2Fms1Kgsg%3D%3D 8910111
40. T Nagata R Schmelzeisen D Mattern G Schwarzer M Ohishi 2005 Application of fuzzy inference to European patients to predict cervical lymph node metastasis in carcinoma of the tongue Int J Oral Maxillofac Surg 34 2 138 142 10.1016/j.ijom.2004.03.012 1:STN:280:DC%2BD2M%2Fms1ejuw%3D%3D 15695041 (Pubitemid 40197760)
41. M Okamoto S Ozeki T Watanabe Y Iida H Tashiro 1988 Cervical lymph node metastasis in carcinoma of the tongue. Correlation between clinical and histopathological findings and metastasis J Craniomaxillofac Surg 16 1 31 34 1:STN:280:DyaL1c7hs1SnsA%3D%3D 3422238
42. LP Kowalski R Bagietto JR Lara RL Santos EK Tagawa IR Santos 1999 Factors influencing contralateral lymph node metastasis from oral carcinoma Head Neck 21 2 104 110 10.1002/(SICI)1097-0347(199903)21:2<104::AID-HED2>3.0.CO;2-L 1:STN:280:DyaK1M7ptVequg%3D%3D 10091977 (Pubitemid 29096096)
43. EW Odell P Jani M Sherriff SM Ahluwalia J Hibbert DA Levison, et al. 1994 The prognostic value of individual histologic grading parameters in small lingual squamous cell carcinomas. The importance of the pattern of invasion Cancer 74 3 789 794 10.1002/1097-0142(19940801)74:3<789::AID- CNCR2820740302>3.0.CO;2-A 1:STN:280:DyaK2czhtlGhsg%3D%3D 8039106 (Pubitemid 24237456)
44. RB Noone H Bonner Jr S Raymond AS Brown WP Graham 3rd HB Lehr 1974 Lymph node metastases in oral carcinoma. A correlation of histopathology with survival Plast Reconstr Surg 53 2 158 166 10.1097/00006534-197402000-00006 1:STN:280:DyaE2c%2Fpt1Kquw%3D%3D 4812025
45. P Ambrosch U Brinck 1996 Detection of nodal micrometastases in head and neck cancer by serial sectioning and immunostaining Oncology (Williston Park) 10 8 1221 1226 1:STN:280:DyaK2s%2FitlKjsA%3D%3D
46. P Hermanek RV Hutter LH Sobin C Wittekind 1999 International Union Against Cancer Classification of isolated tumor cells and micrometastasis Cancer 86 12 2668 2673 10.1002/(SICI)1097-0142(19991215)86:12<2668::AID- CNCR11>3.0.CO;2-R 1:STN:280:DC%2BD3c%2Fmt1GntA%3D%3D 10594862 (Pubitemid 30004671)
47. A Bilde C von Buchwald MH Therkildsen J Mortensen J Kirkegaard B Charabi, et al. 2008 Need for intensive histopathologic analysis to determine lymph node metastases when using sentinel node biopsy in oral cancer Laryngoscope 118 3 408 414 10.1097/MLG.0b013e31815d8e15 18043487 (Pubitemid 351640630)
48. LW Alkureishi GL Ross T Shoaib DS Soutar AG Robertson JA Sorensen, et al. 2008 Does tumor depth affect nodal upstaging in squamous cell carcinoma of the head and neck? Laryngoscope 118 4 629 634 10.1097/MLG.0b013e31815e8bf0 18094651