A combined analysis of genome-wide association studies in breast cancer

Breast Cancer Research and Treatment

Volumn 126, Issue 3, 2011, Pages 717-727

  Li, Jingmei ^a,b   Humphreys, Keith ^a   Heikkinen, Tuomas ^c   Aittomäki, Kristiina ^c   Blomqvist, Carl ^c   Pharoah, Paul D P ^d   Dunning, Alison M ^d   Ahmed, Shahana ^d   Hooning, Maartje J ^e   Martens, John W M ^e   Van Den Ouweland, Ans M W ^e   Alfredsson, Lars ^a   Palotie, Aarno ^f,g   Peltonen Palotie, Leena ^f,g   Irwanto, Astrid ^b   Low, Hui Q ^b   Teoh, Garrett H K ^b   Thalamuthu, Anbupalam ^b   Easton, Douglas F ^d   Nevanlinna, Heli ^c   Liu, Jianjun ^b   Czene, Kamila ^a   Hall, Per ^a   more..

^a KAROLINSKA INSTITUTE   (Sweden)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f UNIVERSITY OF HELSINKI   (Finland)

^g NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Breast neoplasms; Case control studies; Genetic association studies; Genetic epidemiology; Genetic predisposition to disease genetics; Genetic susceptibility

Indexed keywords

ACTIN; ANDROGEN; ESTROGEN; GLYCAN; LINOLENIC ACID;

ADULT; AGED; ANDROGEN METABOLISM; ARTICLE; BREAST CANCER; CANCER INVASION; CANCER SUSCEPTIBILITY; CELL LINEAGE; CHROMOSOME 10Q; CHROMOSOME 14Q; CHROMOSOME 16Q; CHROMOSOME 1P; CHROMOSOME 2Q; CHROMOSOME 3P; CHROMOSOME 5P; CHROMOSOME 8Q; CIRCADIAN RHYTHM; CONTROLLED STUDY; CYTOSKELETON; DRUG METABOLISM; ESTROGEN METABOLISM; FATTY ACID METABOLISM; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HEMATOPOIETIC CELL; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; COMPUTATIONAL BIOLOGY; DATA INTERPRETATION, STATISTICAL; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MODELS, STATISTICAL; MOLECULAR EPIDEMIOLOGY; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79957860523     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1172-9     Document Type: Article

References (44)

1. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, Wareham N, Ahmed S, Healey CS, Bowman R, Meyer KB, Haiman CA, Kolonel LK, Henderson BE, Le Marchand L, Brennan P, Sangrajrang S, Gaborieau V, Odefrey F, Shen CY, Wu PE, Wang HC, Eccles D, Evans DG, Peto J, Fletcher O, Johnson N, Seal S, Stratton MR, Rahman N, Chenevix-Trench G, Bojesen SE, Nordestgaard BG, Axelsson CK, Garcia-Closas M, Brinton L, Chanock S, Lissowska J, Peplonska B, Nevanlinna H, Fagerholm R, Eerola H, Kang D, Yoo KY, Noh DY, Ahn SH, Hunter DJ, Hankinson SE, Cox DG, Hall P, Wedren S, Liu J, Low YL, Bogdanova N, Schurmann P, Dork T, Tollenaar RA, Jacobi CE, Devilee P, Klijn JG, Sigurdson AJ, Doody MM, Alexander BH, Zhang J, Cox A, Brock IW, MacPherson G, Reed MW, Couch FJ, Goode EL, Olson JE, Meijers-Heijboer H, van den Ouweland A, Uitterlinden A, Rivadeneira F, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Hopper JL, McCredie M, Southey M, Giles GG, Schroen C, Justenhoven C, Brauch H, Hamann U, Ko YD, Spurdle AB, Beesley J, Chen X, Mannermaa A, Kosma VM, Kataja V, Hartikainen J, Day NE, Cox DR, Ponder BA (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447(7148):1087-1093. doi:10.1038/nature05887 (Pubitemid 47014426)
2. Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Morrison J, Maranian M, Pooley KA, Luben R, Eccles D, Evans DG, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Stratton MR, Rahman N, Jacobs K, Prentice R, Anderson GL, Rajkovic A, Curb JD, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Diver WR, Bojesen S, Nordestgaard BG, Flyger H, Dork T, Schurmann P, Hillemanns P, Karstens JH, Bogdanova NV, Antonenkova NN, Zalutsky IV, Bermisheva M, Fedorova S, Khusnutdinova E, Kang D, Yoo KY, Noh DY, Ahn SH, Devilee P, van Asperen CJ, Tollenaar RA, Seynaeve C, Garcia-Closas M, Lissowska J, Brinton L, Peplonska B, Nevanlinna H, Heikkinen T, Aittomaki K, Blomqvist C, Hopper JL, Southey MC, Smith L, Spurdle AB, Schmidt MK, Broeks A, van Hien RR, Cornelissen S, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Schmutzler RK, Burwinkel B, Bartram CR, Meindl A, Brauch H, Justenhoven C, Hamann U, Chang-Claude J, Hein R, Wang-Gohrke S, Lindblom A, Margolin S, Mannermaa A, Kosma VM, Kataja V, Olson JE, Wang X, Fredericksen Z, Giles GG, Severi G, Baglietto L, English DR, Hankinson SE, Cox DG, Kraft P, Vatten LJ, Hveem K, Kumle M, Sigurdson A, Doody M, Bhatti P, Alexander BH, Hooning MJ, van den Ouweland AM, Oldenburg RA, Schutte M, Hall P, Czene K, Liu J, Li Y, Cox A, Elliott G, Brock I, Reed MW, Shen CY, Yu JC, Hsu GC, Chen ST, Anton-Culver H, Ziogas A, Andrulis IL, Knight JA, Beesley J, Goode EL, Couch F, Chenevix-Trench G, Hoover RN, Ponder BA, Hunter DJ, Pharoah PD, Dunning AM, Chanock SJ, Easton DF (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 41(5):585-590. doi:10.1038/ng.354
3. Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover RN, Thomas G, Chanock SJ (2007) A genome-wide association study identifies alleles in fgfr2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 39(7):870-874. doi: 10.1038/ng2075 (Pubitemid 47014500)
4. Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S, Cox DG, Hankinson SE, Hutchinson A, Wang Z, Yu K, Chatterjee N, Garcia-Closas M, Gonzalez-Bosquet J, Prokunina-Olsson L, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Diver R, Prentice R, Jackson R, Kooperberg C, Chlebowski R, Lissowska J, Peplonska B, Brinton LA, Sigurdson A, Doody M, Bhatti P, Alexander BH, Buring J, Lee IM, Vatten LJ, Hveem K, Kumle M, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF, Jr., Hoover RN, Chanock SJ, Hunter DJ (2009) A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (rad51l1). Nat Genet 41(5):579-584. doi: 10.1038/ng.353
5. Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J, Gudjonsson SA, Masson G, Jakobsdottir M, Thorlacius S, Helgason A, Aben KK, Strobbe LJ, Albers-Akkers MT, Swinkels DW, Henderson BE, Kolonel LN, Le Marchand L, Millastre E, Andres R, Godino J, Garcia-Prats MD, Polo E, Tres A, Mouy M, Saemundsdottir J, Backman VM, Gudmundsson L, Kristjansson K, Bergthorsson JT, Kostic J, Frigge ML, Geller F, Gudbjartsson D, Sigurdsson H, Jonsdottir T, Hrafnkelsson J, Johannsson J, Sveinsson T, Myrdal G, Grimsson HN, Jonsson T, von Holst S, Werelius B, Margolin S, Lindblom A, Mayordomo JI, Haiman CA, Kiemeney LA, Johannsson OT, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K (2007) Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 39(7):865-869. doi:10.1038/ng2064 (Pubitemid 47014497)
6. Stacey SN, Manolescu A, Sulem P, Thorlacius S, Gudjonsson SA, Jonsson GF, Jakobsdottir M, Bergthorsson JT, Gudmundsson J, Aben KK, Strobbe LJ, Swinkels DW, van Engelenburg KC, Henderson BE, Kolonel LN, Le Marchand L, Millastre E, Andres R, Saez B, Lambea J, Godino J, Polo E, Tres A, Picelli S, Rantala J, Margolin S, Jonsson T, Sigurdsson H, Jonsdottir T, Hrafnkelsson J, Johannsson J, Sveinsson T, Myrdal G, Grimsson HN, Sveinsdottir SG, Alexiusdottir K, Saemundsdottir J, Sigurdsson A, Kostic J, Gudmundsson L, Kristjansson K, Masson G, Fackenthal JD, Adebamowo C, Ogundiran T, Olopade OI, Haiman CA, Lindblom A, Mayordomo JI, Kiemeney LA, Gulcher JR, Rafnar T, Thorsteinsdottir U, Johannsson OT, Kong A, Stefansson K (2008) Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 40(6):703-706. doi:10.1038/ng.131 (Pubitemid 351748861)
7. Zheng W, Long J, Gao YT, Li C, Zheng Y, Xiang YB, Wen W, Levy S, Deming SL, Haines JL, Gu K, Fair AM, Cai Q, Lu W, Shu XO (2009) Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet 41(3):324-328. doi:10.1038/ng.318
8. Ghoussaini M, Pharoah PD (2009) Polygenic susceptibility to breast cancer: current state-of-the-art. Future Oncol 5(5):689-701. doi:10.2217/fon.09.29
9. Peng G, Luo L, Siu H, Zhu Y, Hu P, Hong S, Zhao J, Zhou X, Reveille JD, Jin L, Amos CI, Xiong M (2009) Gene and pathway-based second-wave analysis of genome-wide association studies. Eur J Hum Genet. doi:10.1038/ejhg.2009.115
10. Wang K, Li M, Bucan M (2007) Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet 81(6). doi:10.1086/522374 (Pubitemid 350211456)
11. Magnusson C, Baron J, Persson I, Wolk A, Bergstrom R, Trichopoulos D, Adami HO (1998) Body size in different periods of life and breast cancer risk in post-menopausal women. Int J Cancer 76(1):29-34. doi:10.1002/(SICI)1097- 0215(19980330)76:1<29:AID-IJC6>3.0.CO;2-# (Pubitemid 28164565)
12. Rosenberg LU, Einarsdottir K, Friman EI, Wedren S, Dickman PW, Hall P, Magnusson C (2006) Risk factors for hormone receptor-defined breast cancer in postmenopausal women. Cancer Epidemiol Biomarkers Prev 15(12):2482-2488. doi:10.1158/1055-9965.EPI-06-0489 (Pubitemid 46048309)
13. Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies LR, Li W, Tan AK, Bonnard C, Ong RT, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli JP, Beckman EM, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK (2007) Traf1-c5 as a risk locus for rheumatoid arthritis - a genomewide study. N Engl J Med 357(12):1199-1209. doi:10.1056/NEJMoa073491 (Pubitemid 47443179)
14. Bilguvar K, Yasuno K, Niemela M, Ruigrok YM, von Und Zu Fraunberg M, van Duijn CM, van den Berg LH, Mane S, Mason CE, Choi M, Gaal E, Bayri Y, Kolb L, Arlier Z, Ravuri S, Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H, Koivisto T, Rinne J, Ohman J, Breteler MM, Wijmenga C, State MW, Rinkel GJ, Hernesniemi J, Jaaskelainen JE, Palotie A, Inoue I, Lifton RP, Gunel M (2008) Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet 40(12):1472-1477. doi:10.1038/ng.240
15. Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, Martin NG, Pedersen NL, Kyvik KO, Kaprio J, Hofman A, Freimer NB, Jarvelin MR, Gyllensten U, Campbell H, Rudan I, Johansson A, Marroni F, Hayward C, Vitart V, Jonasson I, Pattaro C, Wright A, Hastie N, Pichler I, Hicks AA, Falchi M, Willemsen G, Hottenga JJ, de Geus EJ, Montgomery GW, Whitfield J, Magnusson P, Saharinen J, Perola M, Silander K, Isaacs A, Sijbrands EJ, Uitterlinden AG, Witteman JC, Oostra BA, Elliott P, Ruokonen A, Sabatti C, Gieger C, Meitinger T, Kronenberg F, Doring A, Wichmann HE, Smit JH, McCarthy MI, van Duijn CM, Peltonen L (2009) Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 41(1):47-55. doi:10.1038/ng.269
16. Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Jakkula E, Coin L, Hoggart C, Collins A, Turunen H, Gabriel S, Elliot P, McCarthy MI, Daly MJ, Jarvelin MR, Freimer NB, Peltonen L (2009) Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 41(1):35-46. doi:10.1038/ng.271
17. Leu M, Humphreys K, Surakka I, Rehnberg E, Muilu J, Rosenstrom P, Almgren P, Jaaskelainen J, Lifton RP, Kyvik KO, Kaprio J, Pedersen NL, Palotie A, Hall P, Gronberg H, Groop L, Peltonen L, Palmgren J, Ripatti S (2010) NordicDB: a nordic pool and portal for genome-wide control data. Eur J Hum Genet. doi: 10.1038/ejhg.2010.112
18. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH (2006) A genome-wide association study identifies il23r as an inflammatory bowel disease gene. Science 314(5804):1461-1463. doi:10.1126/science.1135245 (Pubitemid 44871953)
19. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC (2007) Plink: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3):559-575. doi:10.1086/519795 (Pubitemid 47330214)
20. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38(8):904-909. doi:10.1038/ng1847 (Pubitemid 44141658)
21. O'Dushlaine C, Kenny E, Heron EA, Segurado R, Gill M, Morris DW, Corvin A (2009) The snp ratio test: pathway analysis of genome-wide association datasets. Bioinformatics 25(20):2762-2763. doi:10.1093/bioinformatics/btp448
22. Kanehisa M, Goto S (2000) Kegg: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27-30 (Pubitemid 30047706)
23. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100(16):9440-9445. doi:10.1073/pnas. 15305091001530509100 (Pubitemid 37033947)
24. Storey JD, Tibshirani R (2003) Statistical methods for identifying differentially expressed genes in DNA microarrays. Methods Mol Biol 224:149-157. doi:10.1385/1-59259-364-X:149
25. R Development Core Team (2008) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria
26. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of ld and haplotype maps. Bioinformatics 21(2):263-265. doi:10.1093/bioinformatics/bth457bth457 (Pubitemid 40202029)
27. Cheng D, Knox C, Young N, Stothard P, Damaraju S, Wishart DS (2008) Polysearch: a web-based text mining system for extracting relationships between human diseases, genes, mutations, drugs and metabolites. Nucleic Acids Res 36(Web Server issue):W399- W405. doi:10.1093/nar/gkn296
28. Gamazon ER, Zhang W, Konkashbaev A, Duan S, Kistner EO, Nicolae DL, Dolan ME, Cox NJ (2010) SCAN: SNP and copy number annotation. Bioinformatics 26(2):259-262. doi:10.1093/bioinformatics/btp644
29. Lesueur F, Pharoah PD, Laing S, Ahmed S, Jordan C, Smith PL, Luben R, Wareham NJ, Easton DF, Dunning AM, Ponder BA (2005) Allelic association of the human homologue of the mouse modifier ptprj with breast cancer. Hum Mol Genet 14(16):2349-2356. doi:10.1093/hmg/ddi237 (Pubitemid 41417997)
30. Kiemeney LA, Thorlacius S, Sulem P, Geller F, Aben KK, Stacey SN, Gudmundsson J, Jakobsdottir M, Bergthorsson JT, Sigurdsson A, Blondal T, Witjes JA, Vermeulen SH, Hulsbergen-van de Kaa CA, Swinkels DW, Ploeg M, Cornel EB, Vergunst H, Thorgeirsson TE, Gudbjartsson D, Gudjonsson SA, Thorleifsson G, Kristinsson KT, Mouy M, Snorradottir S, Placidi D, Campagna M, Arici C, Koppova K, Gurzau E, Rudnai P, Kellen E, Polidoro S, Guarrera S, Sacerdote C, Sanchez M, Saez B, Valdivia G, Ryk C, de Verdier P, Lindblom A, Golka K, Bishop DT, Knowles MA, Nikulasson S, Petursdottir V, Jonsson E, Geirsson G, Kristjansson B, Mayordomo JI, Steineck G, Porru S, Buntinx F, Zeegers MP, Fletcher T, Kumar R, Matullo G, Vineis P, Kiltie AE, Gulcher JR, Thorsteinsdottir U, Kong A, Rafnar T, Stefansson K (2008) Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nat Genet 40(11):1307-1312. doi:10.1038/ng.229
31. Cantor RM, Lange K, Sinsheimer JS (2010) Prioritizing GWAS results: a review of statistical methods and recommendations for their application. Am J Hum Genet 86(1):6-22. doi:10.1016/j.ajhg.2009.11.017
32. The Wellcome Trust Case Control Consortium (2007) Genomewide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145):661-678. doi: 10.1038/nature05911 (Pubitemid 46889737)
33. Mao X, Cai T, Olyarchuk JG, Wei L (2005) Automated genome annotation and pathway identification using the kegg orthology (ko) as a controlled vocabulary. Bioinformatics 21(19):3787-3793. doi:10.1093/bioinformatics/bti430 (Pubitemid 41535528)
34. Shen R, Chinnaiyan AM, Ghosh D (2008) Pathway analysis reveals functional convergence of gene expression profiles in breast cancer. BMC Med Genomics 1:28. doi:10.1186/1755-8794-1-28
35. Ma S, Kosorok MR (2010) Detection of gene pathways with predictive power for breast cancer prognosis. BMC Bioinformatics 11:1. doi:10.1186/1471-2105-11-1
36. Chopra P, Shin HJ, Kang J (2008) Global gene map for cancer reveals pathway hotspots. In: Proceedings of the IEEE International conference on Bioinformatics and Biomedicine (BIBM), Philadelphia, USA
37. Gohlke JM, Thomas R, Zhang Y, Rosenstein MC, Davis AP, Murphy C, Becker KG, Mattingly CJ, Portier CJ (2009) Genetic and environmental pathways to complex diseases. BMC Syst Biol 3:46. doi:10.1186/1752-0509-3-46
38. Low YL, Li Y, Humphreys K, Thalamuthu A, Darabi H, Wedren S, Bonnard C, Czene K, Iles MM, Heikkinen T, Aittomaki K, Blomqvist C, Nevanlinna H, Hall P, Liu ET, Liu J (2010) Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility. PLoS Genet 6:e1001012. doi: 10.1371/journal.pgen.1001012
39. Graham JD, Hunt SM, Tran N, Clarke CL (1999) Regulation of the expression and activity by progestins of a member of the sox gene family of transcriptional modulators. J Mol Endocrinol 22(3):295-304 (Pubitemid 29281838)
40. Sud N, Sharma R, Ray R, Chattopadhyay T, Ralhan R (2004) Differential expression of beta mannosidase in human esophageal cancer. Int J Cancer 112(5):905-907. doi:10.1002/ijc.20469 (Pubitemid 39435280)
41. Curran JE, Weinstein SR, Griffiths LR (2002) Polymorphic variants of nfkb1 and its inhibitory protein nfkbia, and their involvement in sporadic breast cancer. Cancer Lett 188(1-2): 103-107. doi:S0304383502004603[pii] (Pubitemid 35292335)
42. Yamashita S, Yamashita J, Sakamoto K, Inada K, Nakashima Y, Murata K, Saishoji T, Nomura K, Ogawa M (1993) Increased expression of membrane-associated phospholipase a2 shows malignant potential of human breast cancer cells. Cancer 71(10):3058-3064 (Pubitemid 23145539)
43. Zhu Y, Stevens RG, Leaderer D, Hoffman A, Holford T, Zhang Y, Brown HN, Zheng T (2008) Non-synonymous polymorphisms in the circadian gene npas2 and breast cancer risk. Breast Cancer Res Treat 107(3):421-425. doi:10.1007/s10549- 007-9565-0 (Pubitemid 351172117)
44. Chen ST, Choo KB, Hou MF, Yeh KT, Kuo SJ, Chang JG (2005) Deregulated expression of the per1, per2 and per3 genes in breast cancers. Carcinogenesis 26(7):1241-1246. doi:10.1093/carcin/bgi075 (Pubitemid 41417901)