A quantitative comparison of the safety margins in the European indicative occupational exposure limits and the derived no-effect levels for workers under REACH

Toxicological Sciences

Volumn 121, Issue 2, 2011, Pages 408-416

  Schenk, Linda ^a   Johanson, Gunnar ^b  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Chemicals regulation; DNEL; IOELV; Occupational exposure limit; REACH; SCOEL

Indexed keywords

1,1,1 TRICHLOROETHANE; DIETHYLENE GLYCOL MONOMETHYL ETHER; ETHANOLAMINE; PYRETHRIN; SODIUM AZIDE; TRIETHYLAMINE;

ARTICLE; COMPARATIVE STUDY; DERIVED NO EFFECT LEVEL; EUROPEAN UNION; HUMAN; LAW; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL EXPOSURE LIMIT; OCCUPATIONAL SAFETY; RISK ASSESSMENT;

EID: 79957844799     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr056     Document Type: Article

References (12)

1. European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). (2010). Guidance on Assessment Factors to Derive a DNEL. Technical Report No. 110. ECETOC, Brussels, Belgium.
2. European Chemicals Agency (ECHA). (2008). Guidance on the Implementation of REACH. Guidance on Information Requirements and Chemical Safety Assessment. Chapter R.8: Characterisation of Dose [Concentration]-Response for Human Health. ECHA, Helsinki, Finland.
3. European Commission (EC). (2006). Registration, Evaluation, Authorization and Restriction of Chemicals (REACH). Regulation (EC) No. 1907/2006 of the European Parliament and of the Council. Off. J. Eur. Commun L396/17, 1-849.
4. EuropeanCommission (EC). (2010).Guidance forEmployers onControllingRisks from Chemicals. Interface between Chemicals Agents Directive and REACH at theWorkplace. European Commission. Available at: http://ec.europa.eu/social/BlobServlet?docId=6126&langId=en. Accessed March 29, 2011.
5. Gromiec, J. (2008). Problems concerning the integration of "derived-no-effectlevels" (DNELs) into occupational safety and health regulations. (Article available in Polish). Med. Pr. 59, 65-73. (Abstract).
6. Kalberlah, F., and Schneider, K. (1998). Quantification of Extrapolation Factors. Final Report of the Research Project No. 116 06 113 of the Federal Environmental Agency. Wirtschaftsverlag NW, Bremerhaven, Germany.
7. Malkiewicz, K., Hansson, S. O., and Rudén, C. (2009). Assessment factors for extrapolation from short-time to chronic exposure-are the REACH guidelines adequate? Toxicol. Lett. 190, 16-22.
8. Nielsen, G. D., and Øvrebø, S. (2008). Background, approaches and recent trends for setting health-based occupational exposure limits: a minireview. Regul. Toxicol. Pharmacol. 51, 253-269.
9. Schenk, L., and Johanson, G. (2010). Use of uncertainty factors by the SCOEL in their derivation of health-based occupational exposure limits. Crit. Rev. Toxicol. 40, 791-798.
10. Scientific Committee on OELs (SCOEL). (1999). Methodology for the Derivation of Occupational Exposure Limits. Key documentation. EUR 19253; European Commission. Office for Official Publications of the European Communities, Luxembourg.
11. Scientific Committee on OELs (SCOEL). (2009a). List of SCOEL Recommendations until 2009. Available at: http://ec.europa.eu/social/BlobServlet?docId-3803&langId-en. Accessed March 29, 2011.
12. Scientific Committee on OELs (SCOEL). (2009b).Methodology for the Derivation of Occupational Exposure Limits. Version 6, December 2009. Available at: http://ec.europa.eu/social/main.jsp?catId=153&langId=en&intPageId=684. Accessed March 29, 2011.