Use of uncertainty factors by the SCOEL in their derivation of health-based Occupational Exposure Limits

Critical Reviews in Toxicology

Volumn 40, Issue 9, 2010, Pages 791-798

  Schenk, Linda ^a   Johanson, Gunnar ^b  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Assessment factor; regulatory toxicology; risk assessment; risk management; safety factor

Indexed keywords

MEDLINE; OCCUPATIONAL EXPOSURE; ORGANIZATION; REVIEW; SCIENTIFIC COMMITTEE ON OCCUPATIONAL EXPOSURE LIMITS; TOXICOLOGICAL PARAMETERS; UNCERTAINTY;

ENVIRONMENTAL MONITORING; HUMANS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; RISK ASSESSMENT; THRESHOLD LIMIT VALUES; UNCERTAINTY;

EID: 77957107850     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2010.507628     Document Type: Review

References (27)

1. Crump K.S.(1984) An improved procedure for low-dose carcinogenic risk assessment from animal data. J Environ Pathol Toxicol Oncol 5:339-348.
2. Deutsche Forschungsgemeinschaft [DFG]. 2009. List of MAK and BAT Values 2009, report No. 45 Weinheim: Wiley VCH Verlag.
3. Dorne JLCM, Renwick AG2005) Te refnement of Uncertainty/Safety factors in Risk Assessment by the Incorporation of data on Toxicokinetic variability in Humans. Toxicol Sci 86(1):20-26.
4. Dourson ML and Stara JF.(1983). Regulatory history and experimental support of uncertaintysafety) factors. Regul Toxicol Pharmacol 3:224-238.
5. Dourson ML, Felter SP, Robinson D.(1996). Evolution of Science-Based Uncertainty Factors in Noncancer Risk Assessment. Regul toxicol Pharmacol 24:108-120.
6. Dourson M, Maier A, Meek B, Renwick A, Ohanian E, Poirier K1998) Boron Tolerable Intake-Re-evaluation of Toxicokinetics for Data-Derives Uncertainty Factors. Biological Trace Element Research 66:453-463.
7. European Chemicals Agency [ECHA].(2008). Guidance on the implementation of REACH. Guidance on information requirements and chemical safety assessment Chapter R.8: Characterisation of dose [concentration]-response for human health.
8. Fairhurst S.(1995). Te uncertainty factor in the setting of occupational exposure standards. Ann occup Hyg 39(3): 375-385.
9. Falk-Filipsson A, Hanberg A, Victorin K, Warholm M, Wallén M.(2007) Assessment factors-applications in health risk assessment of chemicals. Environ res 104(1):108-127.
10. Greenberg M.(2006). Revising the British Occupational Hygiene Society asbestos standard:1968-1982. Am J Ind Med 49(7):577-604.
11. Haber LT, Maier A.(2002). Scientifc criteria used for the development of occupational exposure limits for metals and other mining related chemicals. Regul Toxicol Pharmacol 36:262-279.
12. Hansson SO.(1997). Critcal efects and Exposure Limits. Risk Analysis 17(2):227-236.
13. Hansson SO.(1998). Setting the Limit. Occupational health standards and the limits of science. New York: Oxford University Press.
14. ICPS-International Programme on Chemical Safety2005) Chemical-specifc adjustment factors for interspecies diferences and human variability: guidance document for use of data in dose/concentration-response assessment. Available at: http://whqlibdoc.who.int/publications/2005/9241546786-eng.pdfJuly 1, 2010)
15. Lehman AJ and Fitzhugh OG.(1954) 100-fold margin of safety. Bull Assoc Food Drug Ofc 18:33-35.
16. Markowitz G, Rosner D.(1995). Te Limits of Tresholds-Silica and the Politics of Science, 1935 to 1990. Am J Public Health 85(2):253-262.
17. Nielsen GD, Øvrebø S.(2008). Background, approaches and recent trends for setting health-based occupational exposure limits: A minireview. Regul Toxicol Pharmacol 51(3): 253-269.
18. Paustenbach DJ.(2000) Te History and Biological Basis of Occupational Exposure Limits for Chemical Agents. In: Harris RL. Ed. Patty′s Industrial Hygiene and Toxicology, 4th ed. Vol 3: part IV. New York: Wiley.
19. Piney M.(1998). Exposure limits and health risks arguments for a paradigm shift. In: Bal R and Halfman W., eds. Te politics of chemical risk. Scenarios for a regulatory future. Dordrecht: Kluwer Academic publishers.
20. Pohl HR, Abadin HG.(1995). Utilizing uncertainty factors in minimal risk levels derivation. Regul Toxicol Pharmacol 22(2):180-188.
21. Roach SA and Rappaport SM.(1990). But they are not thresholds: A critical analysis of the documentation of threshold limit values. Am J Ind Med 17(6):727-753.
22. Schenk L, Hansson SO, Rudén C, Gilek M.(2008). Occupational exposure limits: A comparative study. Reg Toxicol Pharmacol 50:261-270.
23. SCOEL.(1999). Methodology for the Derivation of Occupational Exposure Limits. Key documentation. EUR 19253;
24. European Commission. Luxemburg:Ofce for Ofcial Publications of the European Communities.
25. SCOEL.(2009) Methodology for the Derivation of Occupational Exposure Limits: Key Documentationversion 6). Available at: http://ec.europa. eu/social/BlobServlet?docId=4526&langId=enJuly 1, 2010)
26. Stouten H, Ott H, Bouwman C, Wardenbach P.(2008). Reassessment of Occupational Exposure Limits. Am J Ind Med 51:407-418.
27. Vermeire T, Stevenson H, Peiters MN, Rennen M, Slob W, Hakkert BC.(1999). Assessment factors for human health risk assessment: a discussion paper. Crit Rev Toxicol. 295): 439-490.