Growth factors and bone regeneration: How much bone can we expect?

Injury

Volumn 42, Issue 6, 2011, Pages 574-579

  Nauth, Aaron ^a,b   Ristevski, Bill ^a   Li, Ru ^b   Schemitsch, Emil H ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Bone defects; Bone morphogenetic proteins; Bone regeneration; Fibroblast growth factor; Fracture healing; Growth factors; Non union; Platelet derived growth factor; Platelet rich plasma; Vascular endothelial growth factor

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GROWTH FACTOR; OSTEOGENIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; VASCULOTROPIN;

ALLOGRAFT; AUTOGRAFT; BONE CONDUCTION; BONE DEFECT; BONE DEVELOPMENT; BONE REGENERATION; FRACTURE HEALING; HUMAN; INTRAMEDULLARY NAILING; METAPHYSIS; OSTEOSYNTHESIS; OSTEOTOMY; PRIORITY JOURNAL; REVIEW; THROMBOCYTE RICH PLASMA;

BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; BONE TRANSPLANTATION; DRUG DELIVERY SYSTEMS; FRACTURES, BONE; GENE EXPRESSION REGULATION; HUMANS;

EID: 79957827647     PISSN: 00201383     EISSN: 18790267     Source Type: Journal    
DOI: 10.1016/j.injury.2011.03.034     Document Type: Review

References (42)

1. United States Bone and Joint Decade. The burden of musculoskeletal diseases in the United States. Rosemont, IL: American Academy of Orthopaedic Surgeons; 2008.
2. Alsousou J, Thompson M, Hulley P, et al. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg Br 2009;91:987-96.
3. Axelrad TW, Einhorn TA. Bone morphogenetic proteins in orthopaedic surgery. Cytokine Growth Factor Rev 2009;20:481-8.
4. Calori GM, Tagliabue L, Gala L, et al. Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients. Injury 2008;39:1391-402.
5. Canalis E, Centrella M, McCarthy T. Effects of basic fibroblast growth factor on bone formation in vitro. J Clin Invest 1988;81:1572-7.
6. Christian EP, Bosse MJ, Robb G. Reconstruction of large diaphyseal defects, without free fibular transfer, in Grade-IIIB tibial fractures. J Bone Joint Surg Am 1989;71:994-1004. (Pubitemid 19215057)
7. Cook SD, Wolfe MW, Salkeld SL, Rueger DC. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J Bone Joint Surg Am 1995;77:734-50.
8. Dallari D, Savarino L, Stagni C, et al. Enhanced tibial osteotomy healing with use of bone grafts supplemented with platelet gel or platelet gel and bone marrow stromal cells. J Bone Joint Surg Am 2007;89:2413-20. (Pubitemid 350086330)
9. Dimar JR, Glassman SD, Burkus KJ, Carreon LY. Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. Spine 2006;31:2534-9. (Pubitemid 44632234)
10. Dimitriou R, Dahabreh Z, Katsoulis E, et al. Application of recombinant BMP-7 on persistent upper and lower limb non-unions. Injury 2005;36(Suppl. 4):S51-9.
11. Ekrol I, Hajducka C, Court-Brown C, McQueen MM. A comparison of RhBMP-7 (OP-1) and autogenous graft for metaphyseal defects after osteotomy of the distal radius. Injury 2008;39(Suppl. 2):S73-82.
12. Friedlaender GE, Perry CR, Cole JD, et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am 2001;83-A(Suppl. 1):S151-8.
13. Geiger F, Bertram H, Berger I, et al. Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 2005;20:2028-35. (Pubitemid 41532788)
14. Giannoudis PV, Dinopoulos HT. Autologous bone graft: when shall we add growth factors? Orthop Clin North Am 2010;41:85-94.
15. Giannoudis PV, Einhorn TA. Bone morphogenetic proteins in musculoskeletal medicine. Injury 2009;40(Suppl. 3):S1-3.
16. Giannoudis PV, Kanakaris NK, Dimitriou R, et al. The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions. Clin Orthop Relat Res 2009;467:3239-48.
17. Govender S, Csimma C, Genant HK, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am 2002;84-A:2123-34. (Pubitemid 35417689)
18. Graham S, Leonidou A, Lester M, et al. Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing. Expert Opin Invest Drugs 2009;18:1633-54.
19. Hollinger JO, Hart CE, Hirsch SN, et al. Recombinant human platelet-derived growth factor: biology and clinical applications. J Bone Joint Surg Am 2008;90(Suppl. 1):48-54. (Pubitemid 351329121)
20. Jones AL, Bucholz RW, Bosse MJ, et al. Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. J Bone Joint Surg Am 2006;88:1431-41.
21. Kanakaris NK, Calori GM, Verdonk R, et al. Application of BMP-7 to tibial nonunions: a 3-year multicenter experience. Injury 2008;39(Suppl. 2):S83-90.
22. Kato T, Kawaguchi H, Hanada K, et al. Single local injection of recombinant fibroblast growth factor-2 stimulates healing of segmental bone defects in rabbits. J Orthop Res 1998;16:654-9. (Pubitemid 29021894)
23. Kawaguchi H, Nakamura K, Tabata Y, et al. Acceleration of fracture healing in nonhuman primates by fibroblast growth factor-2. J Clin Endocrinol Metab 2001;86:875-80. (Pubitemid 32207509)
24. Kawaguchi H, Oka H, Jingushi S, et al. A local application of recombinant human fibroblast growth factor-2 for tibial shaft fractures: a randomized, placebocontrolled trial. J Bone Miner Res 2010. Epub.
25. Kempen DH, Lu L, Heijink A, et al. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. Biomaterials 2009;30:2816-25.
26. Keramaris NC, Calori GM, Nikolaou VS, et al. Fracture vascularity and bone healing: a systematic review of the role of VEGF. Injury 2008;39(Suppl. 2): S45-57.
27. Kim CS, Kim JI, Kim J, et al. Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers. Biomaterials 2005;26:2501-7. (Pubitemid 39600702)
28. Li R, Stewart DJ, von Schroeder HP, et al. Effect of cell-based VEGF gene therapy on healing of a segmental bone defect. J Orthop Res 2009;27:8-14.
29. Lieberman JR, Daluiski A, Einhorn TA. The role of growth factors in the repair of bone. Biology and clinical applications. J Bone Joint Surg Am2002;84-A:1032-44.
30. Nauth A, Giannoudis PV, Einhorn TA, et al. Growth factors: beyond bone morphogenetic proteins. J Orthop Trauma 2010;24:543-6.
31. Peng H, Wright V, Usas A, et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 2002;110:751-9.
32. Praemer A, Furner FS, Rice D. Musculoskeletal conditions in the United States. Chicago: American Academy of Orthopaedic Surgeons; 1992. p. 85-124.
33. Radomsky ML, Aufdemorte TB, Swain LD, et al. Novel formulation of fibroblast growth factor-2 in a hyaluronan gel accelerates fracture healing in nonhuman primates. J Orthop Res 1999;17:607-14. (Pubitemid 29383624)
34. Ronga M, Baldo F, Zappala G, Cherubino P. Recombinant human bone morphogenetic protein-7 for treatment of long bone non-union: an observational, retrospective, non-randomized study of 105 patients. Injury 2006;37(Suppl. 3):S51-6.
35. Schmidmaier G, Capanna R,Wildemann B, et al. Bone morphogenetic proteins in critical-size bone defects: what are the options? Injury 2009;40(Suppl. 3): S39-43.
36. Schmidmaier G, Herrmann S, Green J, et al. Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone 2006;39:1156-63. (Pubitemid 44540277)
37. Sen MK, Miclau T. Autologous iliac crest bone graft: should it still be the gold standard for treating nonunions? Injury 2007;38(Suppl. 1):S75-80.
38. Swiontkowski MF, Aro HT, Donell S, et al. Recombinant human bone morphogenetic protein-2 in open tibial fractures. A subgroup analysis of data combined fromtwo prospective randomized studies. J Bone Joint SurgAm2006;88:1258-65.
39. Tzioupis C, Giannoudis PV. Prevalence of long-bone non-unions. Injury 2007;38(Suppl. 2):S3-9.
40. Vaccaro AR, Patel T, Fischgrund J, et al. A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. Spine 2004;29:1885-92. (Pubitemid 39181046)
41. Watson JT, Anders M, Moed BR. Management strategies for bone loss in tibial shaft fractures. Clin Orthop Relat Res 1995:138-52.
42. Zimmermann G, Wagner C, Schmeckenbecher K, et al. Treatment of tibial shaft non-unions: bone morphogenetic proteins versus autologous bone graft. Injury 2009;40(Suppl. 3):S50-3.