Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity

Nanotoxicology

Volumn 5, Issue 2, 2011, Pages 157-167

  Jun, Eun Ah ^a   Lim, Kyung Min ^b   Kim, Keunyoung ^a   Bae, Ok Nam ^a   Noh, Ji Yoon ^a   Chung, Kyu Hyuck ^c   Chung, Jin Ho ^a  

^a Seoul National University   (South Korea)

^b AmorePacific Corporation   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

cardiovascular toxicity; platelet aggregation; platelet procoagulant activity; Silver nanoparticles; thrombus formation

Indexed keywords

CALCIUM; PADGEM PROTEIN; PHOSPHATIDYLSERINE; SEROTONIN; SILVER NANOPARTICLE; THROMBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL ISOLATION; CONTROLLED STUDY; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONIN RELEASE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOGENESIS;

ANIMALS; BLOOD COAGULATION; BLOOD PLATELETS; CALCIUM; HUMANS; MALE; METAL NANOPARTICLES; P-SELECTIN; PHOSPHATIDYLSERINES; PLATELET ACTIVATION; PLATELET AGGREGATION; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SILVER; THROMBIN; THROMBOSIS;

RATTUS;

EID: 79957824814     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2010.506250     Document Type: Article

References (36)

1. Bae ON, Lim KM, Noh JY, Chung SM, Kim H, Lee CR, Park JD, Chung JH. 2007. Arsenite-enhanced procoagulant activity through phosphatidylserine exposure in platelets. Chem Res Toxicol 20:1760-1768.
2. Blaser SA, Scheringer M, Macleod M, Hungerbuhler K. 2008. Estimation of cumulative aquatic exposure and risk due to silver: Contribution of nano-functionalized plastics and textiles. Sci Total Environ 390:396-409. (Pubitemid 350256822)
3. Chen X, Schluesener HJ. 2008. Nanosilver: A nanoproduct in medical application. Toxicol Lett 176:1-12. (Pubitemid 350251066)
4. Chung KY, Lim KM, Chung SM, Lee MY, Noh JY, Bae ON, Chung JH. 2006. Shear stress-induced pH increase in plasma is mediated by a decrease in P(CO(2)): The increase in pH enhances shear stress-induced P-selectin expression in platelets. Platelets 17:127-133.
5. Colvin VL. 2003. The potential environmental impact of engineered nanomaterials. Nat Biotechnol 21:1166-1170. (Pubitemid 37203347)
6. do Ceu Monteiro M, Sansonetty F, Goncalves MJ, O'Connor JE. 1999. Flow cytometric kinetic assay of calcium mobilization in whole blood platelets using Fluo-3 and CD41. Cytometry 35:302-310. (Pubitemid 29160228)
7. Gawaz M. 2004. Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium. Cardiovasc Res 61: 498-511. (Pubitemid 38210155)
8. Heemskerk JW, Bevers EM, Lindhout T. 2002. Platelet activation and blood coagulation. Thromb Haemost 88:186-193. (Pubitemid 34873696)
9. Herbert JM, Bernat A, Maffrand JP. 1992. Importance of platelets in experimental venous thrombosis in the rat. Blood 80: 2281-2286.
10. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. 2005. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 19:975-983. (Pubitemid 41563236)
11. Kim YS, Kim JS, Cho HS, Rha DS, Kim JM, Park JD, Choi BS, Lim R, Chang HK, Chung YH, Kwon IH, Jeong J, Han BS, Yu IJ. 2008. Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal Toxicol 20:575-583. (Pubitemid 351601408)
12. Lee JY, Lee MY, Chung SM, Chung JH. 1998. Chemically induced platelet lysis causes vasoconstriction by release of serotonin. Toxicol Appl Pharmacol 149:235-242.
13. Lee MY, Bae ON, Chung SM, Kang KT, Lee JY, Chung JH. 2002. Enhancement of platelet aggregation and thrombus formation by arsenic in drinking water: A contributing factor to cardiovascular disease. Toxicol Appl Pharmacol 179:83-88.
14. Lentz BR. 2003. Exposure of platelet membrane phosphatidylserine regulates blood coagulation. Prog Lipid Res 42:423-438. (Pubitemid 36694106)
15. Lu S, Gao W, Gu HY. 2008. Construction, application and biosafety of silver nanocrystalline chitosan wound dressing. Burns 34:623-628.
16. Monroe DM, Hoffman M, Roberts HR. 2002. Platelets and thrombin generation. Arterioscler Thromb Vasc Biol 22: 1381-1389.
17. Nemmar A, Al-Maskari S, Ali BH, Al-Amri IS. 2007a. Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats. Am J Physiol Lung Cell Mol Physiol 292:L664-670. (Pubitemid 46376984)
18. Nemmar A, Hoet PH, Vandervoort P, Dinsdale D, Nemery B, Hoylaerts MF. 2007b. Enhanced peripheral thrombogenicity after lung inflammation is mediated by platelet-leukocyte activation: Role of P-selectin. J Thromb Haemost 5:1217-1226. (Pubitemid 46902124)
19. Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823-839. (Pubitemid 40984181)
20. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C. 2002. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A 65:1531-1543. (Pubitemid 35217499)
21. Pery AR, Brochot C, Hoet PH, Nemmar A, Bois FY. 2009. Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans. Inhal Toxicol 21:1099-1107.
22. Pope CA 3rd, Hansen ML, Long RW, Nielsen KR, Eatough NL, Wilson WE, Eatough DJ. 2004. Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. Environ Health Perspect 112: 339-345. (Pubitemid 38351397)
23. Radomski A, Jurasz P, Alonso-Escolano D, Drews M, Morandi M, Malinski T, Radomski MW. 2005. Nanoparticle-induced platelet aggregation and vascular thrombosis. Br J Pharmacol 146:882-893. (Pubitemid 41622255)
24. Ruggeri ZM. 2002. Platelets in atherothrombosis. Nat Med 8:1227-1234. (Pubitemid 35373553)
25. Seaton A, Soutar A, Crawford V, Elton R, McNerlan S, Cherrie J, Watt M, Agius R, Stout R. 1999. Particulate air pollution and the blood. Thorax 54:1027-1032. (Pubitemid 29495399)
26. Seyfert UT, Haubelt H, Vogt A, Hellstern P. 2007. Variables influencing Multiplate(R) whole blood impedance platelet aggregometry and turbidimetric platelet aggregation in healthy individuals. Platelets 18:199-206. (Pubitemid 46744118)
27. Shin JH, Lim KM, Noh JY, Bae ON, Chung SM, Lee MY, Chung JH. 2007. Lead-induced procoagulant activation of erythrocytes through phosphatidylserine exposure may lead to thrombotic diseases. Chem Res Toxicol 20:38-43.
28. Shrivastava S, Bera T, Roy A, Singh G, Ramachandrarao P, Dash D. 2007. Characterization of enhanced antibacterial effects of novel silver nanoparticles. Nanotechnology 18: 225103.
29. Smeets EF, Heemskerk JW, Comfurius P, Bevers EM, Zwaal RF. 1993. Thapsigargin amplifies the platelet procoagulant response caused by thrombin. Thromb Haemost 70: 1024-1029. (Pubitemid 24008819)
30. Solum NO. 1999. Procoagulant expression in platelets and defects leading to clinical disorders. Arterioscler Thromb Vasc Biol 19:2841-2846. (Pubitemid 30029808)
31. Stone V, Tuinman M, Vamvakopoulos JE, Shaw J, Brown D, Petterson S, Faux SP, Borm P, MacNee W, Michaelangeli F, Donaldson K. 2000. Increased calcium influx in a monocytic cell line on exposure to ultrafine carbon black. Eur Respir J 15:297-303. (Pubitemid 30085956)
32. Sung JH, Ji JH, Park JD, Yoon JU, Kim DS, Jeon KS, Song MY, Jeong J, Han BS, Han JH, Chung YH, Chang HK, Lee JH, Cho MH, Kelman BJ, Yu IJ. 2009. Subchronic inhalation toxicity of silver nanoparticles. Toxicol Sci 108: 452-461.
33. Vandendries ER, Furie BC, Furie B. 2004. Role of P-selectin and PSGL-1 in coagulation and thrombosis. Thromb Haemost 92:459-466. (Pubitemid 39248002)
34. Yang W, Shen C, Ji Q, An H, Wang J, Liu Q, Zhang Z. 2009. Food storage material silver nanoparticles interfere with DNA replication fidelity and bind with DNA. Nanotechnology 20:85102.
35. Zwaal RF, Comfurius P, Bevers EM. 2005. Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci 62:971-988. (Pubitemid 40655614)
36. Zwaal RF, Schroit AJ. 1997. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 89:1121-1132. (Pubitemid 27079974)