Chemically induced platelet lysis causes vasoconstriction by release of serotonin

Toxicology and Applied Pharmacology

Volumn 149, Issue 2, 1998, Pages 235-242

  Lee, Joo Young ^a   Lee, Moo Yoel ^a   Chung, Seung Min ^a   Chung, Jin Ho ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; KETANSERIN; LACTATE DEHYDROGENASE; MENADIONE; SEROTONIN; SEROTONIN ANTAGONIST; THROMBOXANE A2 RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; MALE; NONHUMAN; RAT; SEROTONIN RELEASE; THROMBOCYTE; VASCULAR ENDOTHELIUM; VASCULAR RING; VASOCONSTRICTION;

ANIMALIA;

EID: 0032053620     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8387     Document Type: Article

References (42)

1. Ashton J. H., Benedict C. R., Fitzgerald C., Raheja S., Taylor A., Campbell W. B., Buja L. M., Willerson J. T. Serotonin as a mediator of cyclic flow variations in stenosed canine coronary arteries. Circulation. 73:1986;572-578.
2. 222. Circulation. 76:1987;952-959.
3. Bax W. A., Renzenbrink G. J., Linden E. A., Zijlstra F. J., Heuven-Nolsen D., Fekkes D., Bos E., Saxena P. R. Low-dose aspirin inhibits platelet-induced contraction of the human isolated coronary artery. Circulation. 89:1994;623-629.
4. Chang M., Shi M., Forman H. J. Exogenous glutathione protects endothelial cells from menadione toxicity. Am. J. Physiol. 262:1992;L637-L643.
5. Chester A. H., Martin G. R., Bodelsson M., Arneklo-Nobin B., Tadjkarimi S., Tornebrandt K., Yacoub M. H. 5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries. Cardiovasc. Res. 24:1990;932-937.
6. 2. Circulation. 87:1993;874-880.
7. Cho Y. S., Kim M. J., Lee J. Y., Chung J. H. The role of thiols in protecting against simultaneous toxicity of menadione to platelet plasma and intracellular membranes. J. Pharmacol. Exp. Ther. 280:1997;1335-1340.
8. Chung J. H., Seo D. C., Chung S. H., Lee J. Y., Kim M. J. Metabolism and cytotoxicity of menadione and its metabolite in rat platelets. Toxicol. Appl. Pharmacol. 142:1997;378-385.
9. 222. Br. J. Pharmacol. 73:1981;773-778.
10. De Clerck F., Van Gorp L., Beetens J., Reneman R. S. Platelet-mediated vascular permeability in the rat: A predominant role for 5-hydroxytryptamine. Thromb. Res. 38:1985;321-339.
11. De Clerck F., Van Nueten J. M. Platelet-mediated vascular contractions: Inhibition of the serotonergic component by ketanserin. Thromb. Res. 27:1982;713-727.
12. 2. Science (Washington, D.C.). 193:1976;1135-1137.
13. Forstermann U., Mugge A., Bode S. M., Frolich J. C. Response of human coronary arteries to aggregating platelets: Importance of endothelium-derived relaxing factor and prostanoids. Circ. Res. 63:1988;306-312.
14. Gant T. W., Rao D. N. R., Mason R. P., Cohen G. M. Redox cycling and sulphhydryl arylation: Their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes. Chem.-Biol. Interact. 65:1988;157-173.
15. 2. Circulation. 79:1989;154-166.
16. Hamberg M., Svensson J., Samuelsson B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Natl. Acad. Sci. USA. 72:1975;2994-2998.
17. Harker L. A. Platelets and vascular thrombosis. N. Engl. J. Med. 330:1994;1006-1007.
18. Hirsh P. D., Hillis L. D., Campbell W. B., Firth B. G., Willerson J. T. Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. N. Engl. J. Med. 304:1981;685-691.
19. Holmsen H., Dangelmaier C. A. Measurement of secretion of serotonin. Methods in Enzymology. Platelets: Receptors, Adhesion, Secretion. 1989;Academic Press, London. p. 205-210.
20. Houston D. S., Shepherd J. T., Vanhoutte P. M. Adenine nucleotides, serotonin, and endothelium-dependent relaxations to platelets. Am. J. Physiol. 248:1985;H389-H395.
21. Kim K. A., Lee J. Y., Park K. S., Kim M. J., Chung J. H. Mechanism of menadione-induced cytotoxicity in rat platelets. Toxicol. Appl. Pharmacol. 138:1996;12-19.
22. Kroll M. H., Schafer A. I. Biochemical mechanisms of platelet activation. Blood. 74:1989;1181-1195.
23. Lam J. Y. T., Chesebro J. H., Steele P. M., Badimon L., Fuster V. Is vasospasm related to platelet deposition? Relationship in a porcine preparation of arterial injuryin vivo. Circulation. 75:1987;243-248.
24. Mandel H. G., Cohn V. H. Vitamin K. Gilman A. G., Goodman L. S., Gilman A. The Pharmacological Basis of Therapeutics. 1980;1592-1596 Macmillan, New York.
25. Marcus A. J., Safier L. B., Kaminski W. E., Islam N., Hajjar K. A., Jendraschak E., Silverstein R. L., Broekman M. J., Schacky C., Fliessbach J. H. Principles of thromboregulation: Control of platelet reactivity in vascular disease. Samuelsson B. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 1995;413-418 Raven Press, New York.
26. Margolin K. A., Akman S. A., Leong L. A., Morgan R. J., Somlo G., Raschko J. W., Ahn C., Doroshow J. H. Phase I study of mitomycin C and menadione in advanced solid tumors. Cancer Chemother. Pharmacol. 36:1995;293-298.
27. McGoon M. D., Vanhoutte P. M. Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. J. Clin. Invest. 74:1984;828-833.
28. 2. J. Am. Coll. Cardiol. 15:1990;727-729.
29. Melgar M. J., Anadon A., Bello J. Effects of menadione on the cardiovascular system. Vet. Hum. Toxicol. 33:1991;110-114.
30. Meyers K. M., Holmsen H., Seachord C. L. Comparative study of platelet dense granule constituents. Am. J. Physiol. 243:1982;R454-R461.
31. Mullane K. M., Bradley G., Moncada S. The interactions of platelet-derived mediators on isolated canine coronary arteries. Eur. J. Pharmacol. 84:1982;115-118.
32. Nemecek G. M., Coughlin S. R., Handley D. A., Moskowitz M. A. Stimulation of aortic smooth muscle cell mitogenesis by serotonin. Proc. Natl. Acad. Sci. USA. 83:1986;674-678.
33. Packham M. A. Role of platelets in thrombosis and hemostasis. Can. J. Physiol. Pharmacol. 72:1994;278-284.
34. Paulus, J. M. Aster, R. H. 1990, Clinical evaluation of thrombokinetics, Hematology, W. J. WilliamsE. BeutlerA. J. ErslevM. A. Lichtman, 1260, 1266, McGraw-Hill, New York.
35. Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature. 362:1993;801-809.
36. 2. Hypertension. 26:1995;771-780.
37. Seung S. A., Lee J. Y., Lee M. Y., Park J. S., Chung J. H. The relative importance of oxidative stress versus arylation in the mechanism of quinone-induced cytotoxicity to platelets. Chem. Biol. Interact. 1998.
38. 2. Circulation. 64:1981;1107-1115.
39. Van den Berg E. K., Schmitz J. M., Benedict C. R., Malloy C. R., Willerson J. T., Dehmer G. J. Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphology. Circulation. 79:1989;116-124.
40. Vanhoutte P. M., Houston D. S. Platelets, endothelium and vasospasm. Circulation. 72:1985;728-734.
41. Willerson J. T., Golino P., Eidt J., Campbell W. B., Buja L. M. Specific platelet mediators and unstable coronary artery lesions: Experimental evidence and potential clinical implications. Circulation. 80:1989;198-205.
42. Yang B. C., Mehta J. L. Platelets increase the tone of quiescent rat aortic rings by release of serotonin and potentiate the subsequent contractile response to norepinephrine. J. Cardiovasc. Pharmacol. 23:1994;387-394.