Advances in understanding regulatory myeloid cells

Cancer Biology and Therapy

Volumn 11, Issue 11, 2011, Pages 923-926

  Romano, Alessandra ^a,b   Vetro, Calogero ^b   Adriani, Marsilio ^c  

^a Ospedale Ferrarotto   (Italy)

^b SCUOLA SUPERIORE DI CATANIA   (Italy)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Antitumor immunity; Immune tolerance; Immunotherapy; Regulatory myeloid cells; ROS; T cell; T reg

Indexed keywords

ALEFACEPT; BEVACIZUMAB; FINGOLIMOD; GEMCITABINE; PLACEBO; RETINOIC ACID; SILDENAFIL; SUNITINIB; TADALAFIL; VARDENAFIL;

ADJUVANT THERAPY; BONE MARROW CELL; CANCER IMMUNOTHERAPY; CANCER PATIENT; CELL EXPANSION; CELL FUNCTION; CELL METABOLISM; CELL MIGRATION; CELL SELECTION; CONFERENCE PAPER; HUMAN; IMMUNE SYSTEM; IMMUNOREGULATION; LYMPHOPROLIFERATIVE DISEASE; MOLECULAR INTERACTION; MYELOID DERIVED SUPPRESSOR CELL; MYELOPOIESIS; NONHUMAN; TUMOR MICROENVIRONMENT; TUMOR PROMOTION;

ANIMALS; CELL BIOLOGY; HUMANS; IMMUNE TOLERANCE; IMMUNOTHERAPY; MYELOID CELLS; NEOPLASMS; SUPPRESSOR FACTORS, IMMUNOLOGIC; TUMOR MICROENVIRONMENT;

EID: 79957813568     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.11.11.15541     Document Type: Conference Paper

References (7)

1. The Regulatory Myeloid Cells - International Immunopharmacology Conference. Available at: http://www.immunopharmacology.elsevier.com/.
2. Schmielau J, Finn OJ. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res 2001; 61:4756-60; PMID: 11406548.
3. Martino A, Badell E, Abadie V, Balloy V, Chignard M, Mistou MY, et al. Mycobacterium bovis Bacillus Calmette-Guérin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo T cell priming via IL-1R-dependent nitric oxide production. J Immunol 2010; 184:2038-47; PMID: 20083674; DOI: 10.4049/jimmunol.0903348.
4. Condamine T, Gabrilovich D. Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol 2011; 32:19-25; PMID: 21067974; DOI: 10.1016/j.it.2010.10.002.
5. Talmadge JE. Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy Clin. Cancer Res 2007; 13:5243-8; PMID: 17875751; DOI: 10.1158/1078-0432.CCR-07-0182.
6. Serafini P, Meckel K, Kelso M, Noonan K, Califano J, Koch W, et al. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med 2006; 203:2691-702; PMID: 17101732; DOI: 10.1084/jem.20061104.
7. Ferrara N. Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis. Curr Opin Hematol 2010; 17:219-24; PMID: 20308892; DOI: 10.1097/MOH.0b013e3283386660.