Conformationally constrained histidines in the design of peptidomimetics: Strategies for the χ-space control

International Journal of Molecular Sciences

Volumn 12, Issue 5, 2011, Pages 2853-2890

  Stefanucci, Azzurra ^a   Pinnen, Francesco ^a   Feliciani, Federica ^a   Cacciatore, Ivana ^a   Lucente, Gino ^b   Mollica, Adriano ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

space; Alkyl substitution; Amino acids; Conformation; Histidine; Stereoselective synthesis

Indexed keywords

1 (4 IMIDAZOLYL)ALKYL CHLORIDE; 1 AMINO 2 (4 IMIDAZOLYL)CYCLOPROPANECARBOXYLIC ACID DERIVATIVE; 2 ACETAMIDO 3 [IMIDAZOL 4(5)YL ACRYLIC]ACID; 2 ALKYL 2 (4 IMIDAZOLYLMETHYL)ACETOACETIC ACID; 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ALPHA AMINO 1,2,3 TRIAZOLE 4 PROPIONIC ACID; ALPHA BENZAMIDO 1,2,3 TRIAZOLE 4 PROPIONIC ACID; ALPHA HYDROGEN; ALPHABETA DEHYDROHISTIDINE; AZA HISTIDINE; AZLACTONE; BETA HYDROGEN; BETA METHYLHISTIDINE DERIVATIVE; BETA2 HOMO HISTIDINE; DIETHYL ACETAMIDOMALONATE; HISTIDINE DERIVATIVE; HOMO HISTIDINE; HYDROGEN; IMIDAZOLE 5 METHANOL; IMIDAZOLYLGLYCINE; N TOSYL ACETOXYMETHYLIMIDAZOLE; N TRITYL 4 CYANOMETHYLIMIDAZOLE; NOR HISTIDINE; PEPTIDOMIMETIC AGENT; PILOCARPINE DERIVATIVE; SPINACINE DERIVATIVE; UNCLASSIFIED DRUG; CYCLOPROPANE; CYCLOPROPANE DERIVATIVE; HISTIDINE;

ALKYLATION; ARTICLE; DIASTEREOISOMER; DRUG DESIGN; DRUG SYNTHESIS; EPIMERIZATION; NUCLEOPHILICITY; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; STEREOCHEMISTRY; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; CHEMICAL STRUCTURE; CHEMISTRY; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

CYCLOPROPANES; HISTIDINE; MODELS, MOLECULAR; PEPTIDOMIMETICS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79957810027     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12052853     Document Type: Article

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