Nanocrystallization of poorly water soluble drugs for parenteral administration

Journal of Biomedical Nanotechnology

Volumn 7, Issue 1, 2011, Pages 127-129

  Zakir, Foziyah ^a,b   Sharma, Himanshu ^b   Kaur, Karandeep ^b   Malik, Basant ^b   Vaidya, Bhuvaneshwer ^c   Goyal, Amit K ^c   Vyas, S P ^c  

^a Rayat Institute of Pharmacy   (India)

^b ISF COLLEGE OF PHARMACY   (India)

^c DR H S GOUR UNIVERSITY   (India)

Author keywords

Amphotericin B; Nanosuspension; Poor solubility

Indexed keywords

ACTIVE SUBSTANCE; AMPHOTERICIN B; COMBINATORIAL CHEMISTRY; HIGH-THROUGHPUT SCREENING; MODEL DRUGS; NANO-SUSPENSIONS; PARENTERAL ADMINISTRATION; PHARMACOKINETIC PROFILES; PLURONIC-F68; POORLY WATER-SOLUBLE DRUGS; TWEEN 80;

BIOASSAY; BIOCHIPS; PHOSPHOLIPIDS; SOLUBILITY; SURFACE ACTIVE AGENTS;

ENZYME INHIBITION;

AMPHOTERICIN B; NANOCRYSTAL; ANTIINFECTIVE AGENT; NANOCAPSULE; WATER;

ARTICLE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG TISSUE LEVEL; KIDNEY; LIVER; LUNG; PARTICLE SIZE; SPLEEN; SUSPENSION; ANIMAL; ANTIBODY SPECIFICITY; CHEMISTRY; CRYSTALLIZATION; INFUSION; METABOLIC CLEARANCE RATE; METHODOLOGY; RAT; SOLUBILITY; TISSUE DISTRIBUTION;

AMPHOTERICIN B; ANIMALS; ANTI-BACTERIAL AGENTS; CRYSTALLIZATION; INFUSIONS, PARENTERAL; METABOLIC CLEARANCE RATE; NANOCAPSULES; ORGAN SPECIFICITY; RATS; SOLUBILITY; TISSUE DISTRIBUTION; WATER;

EID: 79957738639     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2011.1234     Document Type: Article

References (2)

1. V. B. Patravale, A. A. Date, and R. M. Kulkarni, Nanosuspensions: A promising drug delivery strategy. J. Pharm Pharmacol. 56, 827 (2004).
2. P. Kocbek, S. Baumgartner, and P. Kristl, Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs. Int. J. Pharmaceutics. 312, 179 (2006).