DRB1*15 allele is a risk factor for PR3-ANCA disease in African Americans

Journal of the American Society of Nephrology

Volumn 22, Issue 6, 2011, Pages 1161-1167

  Cao, Yali ^a   Schmitz, John L ^a   Yang, Jiajin ^a   Hogan, Susan L ^a   Bunch, Donna ^a   Hu, Yichun ^a   Jennette, Caroline E ^a   Berg, Elisabeth A ^a   Arnett, Frank C ^b   Jennette, J Charles ^a   Falk, Ronald J ^a   Preston, Gloria A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; HLA DR ANTIGEN; MYELOPEROXIDASE; PROTEINASE 3 NEUTROPHIL CYTOPLASMIC AUTOANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; EPITOPE; HLA DRB1*15 ANTIGEN; HLA-DRB1*15 ANTIGEN;

ADOLESCENT; ADULT; AFRICAN AMERICAN; AGED; ALLELE; AMINO ACID SEQUENCE; ANCA ASSOCIATED VASCULITIS; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CAUCASIAN; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEINASE 3 NEUTROPHIL CYTOPLASMIC AUTOANTIBODY DISEASE; RISK FACTOR; SCHOOL CHILD; CASE CONTROL STUDY; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; WEGENER GRANULOMATOSIS;

ADOLESCENT; ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; ALLELES; CASE-CONTROL STUDIES; CHILD; EPITOPES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; WEGENER GRANULOMATOSIS; YOUNG ADULT;

EID: 79957720209     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010101058     Document Type: Article

References (27)

1. Hay EM, Beaman M, Ralston AJ, Ackrill P, Bernstein RM, Holt PJ: Wegener's granulomatosis occurring in siblings. Br J Rheumatol 30: 144-145, 1991
2. Muniain MA, Moreno JC, Gonzalez Campora R: Wegener's granulomatosis in two sisters. Ann Rheum Dis 45: 417-421, 1986 (Pubitemid 16121721)
3. Nowack R, Lehmann H, Flores-Suarez LF, Nanhou A, van der Woude FJ: Familial occurrence of systemic vasculitis and rapidly progressive glomerulonephritis. Am J Kidney Dis 34: 364-373, 1999 (Pubitemid 29362108)
4. Manganelli P, Giacosa R, Fietta P, Zanetti A, Neri TM: Familial vasculitides: Churg-strauss syndrome and Wegener's granulomatosis in 2 first-degree relatives. J Rheumatol 30: 618-621, 2003 (Pubitemid 36301958)
5. O'Donnell JL, Stevanovic VR, Frampton C, Stamp LK, Chapman PT: Wegener's granulomatosis in New Zealand: Evidence for a latitudedependent incidence gradient. Intern Med J 37: 242-246, 2007 (Pubitemid 46457498)
6. Mahr A, Guillevin L, Poissonnet M, Ayme S: Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener's Granulomatosis, and Churg-strauss syndrome in a French urban multiethnic population in 2000: A capture-recapture estimate. Arthritis Rheum 51: 92-99, 2004
7. Hogan SL, Falk RJ, Chin H, Cai J, Jennette CE, Jennette JC, Nachman PH: Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis. Ann Intern Med 143: 621-631, 2005
8. Yang J, Bautz DJ, Lionaki S, Hogan SL, Chin H, Tisch RM, Schmitz JL, Pressler BM, Jennette JC, Falk RJ, Preston GA: ANCA patients have T cells responsive to complementary PR-3 antigen. Kidney Int 74: 1159-1169, 2008
9. Payami H, Joe S, Farid NR, Stenszky V, Chan SH, Yeo PP, Cheah JS, Thomson G: Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease. Am J Hum Genet 45: 541-546, 1989 (Pubitemid 19261441)
10. Baldassarre LA, Steiner NK, Jones P, Tang T, Slack R, Ng J, Hartzman RJ, Hurley CK: Limited diversity of HLA-DRB1*02 alleles and DRB1-DRB5 haplotype associations in four United States population groups. Tissue Antigens 61: 249-252, 2003 (Pubitemid 36605547)
11. Elkon KB, Sutherland DC, Rees AJ, Hughes GR, Batchelor JR: HLA antigen frequencies in systemic vasculitis: Increase in HLA-DR2 in Wegener's granulomatosis. Arthritis Rheum 26: 102-105, 1983 (Pubitemid 13175209)
12. Spencer SJ, Burns A, Gaskin G, Pusey CD, Rees AJ: HLA class ii specificities in vasculitis with antibodies to neutrophil cytoplasmic antigens. Kidney Int 41: 1059-1063, 1992
13. Pendergraft WF 3rd, Preston GA, Shah RR, Tropsha A, Carter CW Jr., Jennette JC, Falk RJ: Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3. Nat Med 10: 72-79, 2004 (Pubitemid 38524701)
14. Griffith ME, Coulthart A, Pemberton S, George AJ, Pusey CD: Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site. Clin Exp Immunol 123: 170-177, 2001 (Pubitemid 32118854)
15. Van Der Geld YM, Simpelaar A, Van Der Zee R, Tervaert JW, Stegeman CA, Limburg PC, Kallenberg CG: Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: Epitope analysis using synthetic peptides. Kidney Int 59: 147-159, 2001 (Pubitemid 32055223)
16. Williams RC Jr., Staud R, Malone CC, Payabyab J, Byres L, Underwood D: Epitopes on proteinase-3 recognized by antibodies from patients with Wegener's granulomatosis. J Immunol 152: 4722-4737, 1994 (Pubitemid 24134434)
17. Wang P, Sidney J, Dow C, Mothe B, Sette A, Peters B: A systematic assessment of MHC class ii peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol 4: e1000048, 2008
18. Sandilands GP, McCrae J, Hill K, Perry M, Baxter D: Major histocompatibility complex class ii (DR) antigen and costimulatory molecules on in vitro and in vivo activated human polymorphonuclear neutrophils. Immunology 119: 562-571, 2006 (Pubitemid 44722219)
19. Hansch GM, Radsak M, Wagner C, Reis B, Koch A, Breitbart A, Andrassy K: Expression of major histocompatibility class ii antigens on polymorphonuclear neutrophils in patients with Wegener's Granulomatosis. Kidney Int 55: 1811-1818, 1999
20. Iking-Konert C, Vogt S, Radsak M, Wagner C, Hansch GM, Andrassy K: Polymorphonuclear neutrophils in Wegener's Granulomatosis acquire characteristics of antigen presenting cells. Kidney Int 60: 2247-2262, 2001 (Pubitemid 33070467)
21. Gosselin EJ, Wardwell K, Rigby WF, Guyre PM: Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma, and IL-3. J Immunol 151: 1482-1490, 1993 (Pubitemid 23219286)
22. Rammensee HG, Friede T, Stevanoviic S: MHC ligands and peptide motifs: First listing. Immunogenetics 41: 178-228, 1995
23. Oehler L, Majdic O, Pickl WF, Stockl J, Riedl E, Drach J, Rappersberger K, Geissler K, Knapp W: Neutrophil granulocyte-committed cells can be driven to acquire dendritic cell characteristics. J Exp Med 187: 1019-1028, 1998 (Pubitemid 28176402)
24. Hogan SL, Nachman PH, Wilkman AS, Jennette JC, Falk RJ: Prognostic markers in patients with antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 7: 23-32, 1996 (Pubitemid 26067088)
25. Nachman PH, Hogan SL, Jennette JC, Falk RJ: Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 7: 33-39, 1996 (Pubitemid 26067089)
26. Pagnoux C, Hogan SL, Chin H, Jennette JC, Falk RJ, Guillevin L, Nachman PH: Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: Comparison of two independent cohorts. Arthritis Rheum 58: 2908-2918, 2008
27. Martinez A, Gual L, Fernandez-Arquero M, Nogales A, Ferreira A, Garcia-Rodriguez MC, Fontan G, de la Concha Ed EG: Epistatic effects occurring among susceptibility and protective MHC genes in igA deficiency. Genes Immun 4: 316-320, 2003 (Pubitemid 39562132)