In vivo oxidation, platelet activation and simultaneous occurrence of natural immunity in atherosclerosis-prone mice

Israel Medical Association Journal

Volumn 13, Issue 5, 2011, Pages 278-283

  Shen, Lianhua ^a   Matsunami, Yukana ^a   Quan, Nanhu ^a   Kobayashi, Kazuko ^a   Matsuura, Eiji ^a   Oguma, Keiji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

11 dehydrothromboxane B2; Atherosclerosis; Beta 2 glycoprotein I ( 2GPI); Natural antibodies; Oxidized low density lipoprotein (oxLDL)

Indexed keywords

11 OXOTHROMBOXANE B2; 8 HYDROXYDEOXYGUANOSINE; APOLIPOPROTEIN E; AUTOANTIGEN; BETA2 GLYCOPROTEIN 1; BIOLOGICAL MARKER; CHOLESTEROL; IMMUNOGLOBULIN M ANTIBODY; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN DETECTION; ARTICLE; ATHEROSCLEROSIS; AUTOIMMUNITY; BLOOD CLOTTING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HETEROZYGOSITY; HYPERCHOLESTEROLEMIA; IMMUNOREGULATION; IN VIVO STUDY; INNATE IMMUNITY; LIPID OXIDATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; REGULATORY MECHANISM; THROMBOCYTE ACTIVATION; URINE LEVEL;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BETA 2-GLYCOPROTEIN I; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; IMMUNITY, INNATE; IMMUNOGLOBULIN M; LIPOPROTEINS, LDL; MALE; MICE; OXIDATIVE STRESS; PLATELET ACTIVATION; RECEPTORS, LDL; THROMBOXANE B2;

EID: 79957656437     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Miller YI, Chang MK, Binder CJ, et al. Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol 2003; 14: 437-45.
2. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 1997; 272: 20963-6.
3. Matsuura E, Igarashi Y, Fujimoto M, et al. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 1990; 336: 177-8.
4. Matsuura E, Igarashi Y, Fujimoto M, et al. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol 1992; 148: 3885-91.
5. Matsuura E, Igarashi Y, Yasuda T, et al. Anticardiolipin antibodies recognize β2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J Exp Med 1994; 179: 457-62.
6. Hasunuma Y, Matsuura E, Makita Z, et al. Involvement of β2-glycoprotein I and anticardiolipin antibodies in oxidatively modified low-density lipoprotein uptake by macrophages. Clin Exp Immunol 1997; 107: 569-73.
7. Kobayashi K, Matsuura E, Liu Q, et al. A specific ligand for β2-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages. J Lipid Res 2001; 42: 697-709.
8. Kobayashi K, Kishi M, Atsumi T, et al. Circulating oxidized LDL forms complexes with β2-glycoprotein I: implication as an atherogenic autoantigen. J Lipid Res 2003; 44: 716-26.
9. Lopez D, Garcia-Valladares I, Palafox-Sanchez CA, et al. Oxidized lowdensity lipoprotein/β2-glycoprotein I complexes and autoantibodies to oxLig-1/β2-glycoprotein I in patients with systemic lupus erythematosus and antiphospholipid syndrome. Am J Clin Pathol 2004; 121: 426-36.
10. Tabuchi M, Inoue K, Usui-Kataoka H, et al. The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis. J Lipid Res 2007; 48: 768-81.
11. Matsuura E, Kobayashi K, Tabuchi M, et al. Oxidative modification of lowdensity lipoprotein and immune regulation of atherosclerosis. Prog Lipid Res 2006; 45: 466-86.
12. Kuwana M, Matsuura E, Kobayashi K, et al. Binding of β2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells. Blood 2005; 105: 1552-7.
13. Yamaguchi Y, Seta N, Kaburaki J, et al. Excessive exposure to anionic surfaces maintains autoantibody response to β2-glycoprotein I in patients with antiphospholipid syndrome. Blood 2007; 110: 43121-8.
14. Palinski W, Horkko S, Miller E, et al. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma. J Clin Invest 1996; 98: 800-14.
15. Ayada K, Yokota K, Hirai K, et al. Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis. Lupus 2009; 18: 1154-68.
16. Zhang SH, Reddick RL, Piedrahita JA, et al. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992; 258: 468-71.
17. Ishibashi S, Goldstein JL, Brown MS, et al. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest 1994; 93: 1885-93.
18. Palinski W, Ord VA, Plump AS, et al. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehydelysine in serum. Arterioscler Thromb 1994; 14: 605-16.