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Volumn 300, Issue 6, 2011, Pages

Complex regulation of GH autofeedback under dual-peptide drive: Studies under a pharmacological GH and sex steroid clamp

Author keywords

Androgen; Estrogen; Growth hormone; Sex difference

Indexed keywords

ESTRADIOL; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; PLACEBO; PRALMORELIN; SEX HORMONE; SODIUM CHLORIDE; TESTOSTERONE;

EID: 79957635124     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00054.2011     Document Type: Article
Times cited : (7)

References (50)
  • 1
    • 0027422182 scopus 로고
    • Insulin-like growth factor-I modulates hypothalamic somatostatin through growth hormone releasingfactor increased somatostatin release and messenger ribonucleic acid levels
    • Aguila MC, Boggaram V, McCann SM. Insulin-like growth factor-I modulates hypothalamic somatostatin through growth hormone releasingfactor increased somatostatin release and messenger ribonucleic acid levels. Brain Res 625: 213-218, 1993.
    • (1993) Brain Res , vol.625 , pp. 213-218
    • Aguila, M.C.1    Boggaram, V.2    McCann, S.M.3
  • 2
    • 0035095289 scopus 로고    scopus 로고
    • Short-term estradiol supplementation augments growth hormone (GH) secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women
    • Anderson SM, Shah N, Evans WS, Patrie JT, Bowers CY, Veldhuis JD. Short-term estradiol supplementation augments growth hormone (GH) secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women. J Clin Endocrinol Metab 86: 551-560, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 551-560
    • Anderson, S.M.1    Shah, N.2    Evans, W.S.3    Patrie, J.T.4    Bowers, C.Y.5    Veldhuis, J.D.6
  • 3
    • 0032034505 scopus 로고    scopus 로고
    • Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging
    • Arvat E, Ceda GP, Di Vito L, Ramunni J, Gianotti L, Broglio F, Deghenghi R, Ghigo E. Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging. Pituitary 1: 51-58, 1998.
    • (1998) Pituitary , vol.1 , pp. 51-58
    • Arvat, E.1    Ceda, G.P.2    di Vito, L.3    Ramunni, J.4    Gianotti, L.5    Broglio, F.6    Deghenghi, R.7    Ghigo, E.8
  • 4
    • 0021828930 scopus 로고
    • Independent effects of growth hormone releasing factor on growth hormone release and gene transcription
    • Barinaga M, Bilezikjian LM, Vale WW, Rosenfeld MG, Evans RM. Independent effects of growth hormone releasing factor on growth hormone release and gene transcription. Nature 314: 279-281, 1985.
    • (1985) Nature , vol.314 , pp. 279-281
    • Barinaga, M.1    Bilezikjian, L.M.2    Vale, W.W.3    Rosenfeld, M.G.4    Evans, R.M.5
  • 5
    • 0001625051 scopus 로고    scopus 로고
    • Synergistic release of growth hormone by GHRP and GHRH: Scope and implication
    • edited by Bercu BB and Walker RF, New York: Marcel Dekker
    • Bowers CY. Synergistic release of growth hormone by GHRP and GHRH: scope and implication. In: Growth Hormone Secretagogues in Clinical Practice, edited by Bercu BB and Walker RF. New York: Marcel Dekker, 1998, p. 1-25.
    • (1998) Growth Hormone Secretagogues In Clinical Practice , pp. 1-25
    • Bowers, C.Y.1
  • 6
    • 2442597828 scopus 로고    scopus 로고
    • Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women
    • Bowers CY, Granda R, Mohan S, Kuipers J, Baylink D, Veldhuis JD. Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women. J Clin Endocrinol Metab 89: 2290-2300, 2004.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2290-2300
    • Bowers, C.Y.1    Granda, R.2    Mohan, S.3    Kuipers, J.4    Baylink, D.5    Veldhuis, J.D.6
  • 7
    • 0025292632 scopus 로고
    • Sex difference in growth hormone feedback in the rat
    • Carlsson LM, Clark RG, Robinson IC. Sex difference in growth hormone feedback in the rat. J Endocrinol 126: 27-35, 1990.
    • (1990) J Endocrinol , vol.126 , pp. 27-35
    • Carlsson, L.M.1    Clark, R.G.2    Robinson, I.C.3
  • 8
    • 12244310806 scopus 로고    scopus 로고
    • Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects
    • Chen JW, Højlund K, Beck-Nielsen H, Sandahl Christiansen J, Orskov H, Frystyk J. Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects. J Clin Endocrinol Metab 90: 366-371, 2005.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 366-371
    • Chen, J.W.1    Højlund, K.2    Beck-Nielsen, H.3    Sandahl, C.J.4    Orskov, H.5    Frystyk, J.6
  • 9
    • 0019740282 scopus 로고
    • Intraventrically injected growth hormone stimulates somatostatin release into rat hypophyseal portal blood
    • Chihara K, Minamitani N, Kaji H, Arimura A, Fujita T. Intraventrically injected growth hormone stimulates somatostatin release into rat hypophyseal portal blood. Endocrinology 109: 2279-2281, 1981.
    • (1981) Endocrinology , vol.109 , pp. 2279-2281
    • Chihara, K.1    Minamitani, N.2    Kaji, H.3    Arimura, A.4    Fujita, T.5
  • 10
    • 0024232096 scopus 로고
    • The rebound release of growth hormone (GH) following somatostatin infusion in rats involves hypothalamic GH-releasing factor release
    • Clark RG, Carlsson LM, Rafferty B, Robinson IC. The rebound release of growth hormone (GH) following somatostatin infusion in rats involves hypothalamic GH-releasing factor release. J Endocrinol 119: 397-404, 1988.
    • (1988) J Endocrinol , vol.119 , pp. 397-404
    • Clark, R.G.1    Carlsson, L.M.2    Rafferty, B.3    Robinson, I.C.4
  • 11
    • 0035095877 scopus 로고    scopus 로고
    • Continuous 24-hour intravenous infusion of recombinant human growth hormone (GH)-releasing hormone-(1,44)-amide augments pulsatile, entropic, and daily rhythmic GH secretion in postmenopausal women equally in the estrogen-withdrawn and estrogen-supplemented states
    • Evans WS, Anderson SM, Hull LT, Azimi PP, Bowers CY, Veldhuis JD. Continuous 24-hour intravenous infusion of recombinant human growth hormone (GH)-releasing hormone-(1,44)-amide augments pulsatile, entropic, and daily rhythmic GH secretion in postmenopausal women equally in the estrogen-withdrawn and estrogen-supplemented states. J Clin Endocrinol Metab 86: 700-712, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 700-712
    • Evans, W.S.1    Anderson, S.M.2    Hull, L.T.3    Azimi, P.P.4    Bowers, C.Y.5    Veldhuis, J.D.6
  • 12
    • 0028929627 scopus 로고
    • Central effects of growth hormone- releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action
    • Fairhall KM, Mynett A, Robinson IC. Central effects of growth hormone- releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action. J Endocrinol 144: 555-560, 1995.
    • (1995) J Endocrinol , vol.144 , pp. 555-560
    • Fairhall, K.M.1    Mynett, A.2    Robinson, I.C.3
  • 13
    • 19344376665 scopus 로고    scopus 로고
    • Deterministic construct of amplifying actions of ghrelin on pulsatile GH secretion
    • Farhy LS, Veldhuis JD. Deterministic construct of amplifying actions of ghrelin on pulsatile GH secretion. Am J Physiol Regul Integr Comp Physiol 288: R1649-R1663, 2005.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288
    • Farhy, L.S.1    Veldhuis, J.D.2
  • 14
    • 84886638581 scopus 로고
    • Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion
    • Ferland L, Labrie F, Jobin M, Arimura A, Schally AV. Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion. Biochem Biophys Res Commun 68: 149-156, 1976.
    • (1976) Biochem Biophys Res Commun , vol.68 , pp. 149-156
    • Ferland, L.1    Labrie, F.2    Jobin, M.3    Arimura, A.4    Schally, A.V.5
  • 15
    • 0030137205 scopus 로고    scopus 로고
    • Growth hormone-releasing and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6
    • Fletcher TP, Thomas GB, Clarke IJ. Growth hormone-releasing and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6. Domest Anim Endocrinol 13: 251-258, 1996.
    • (1996) Domest Anim Endocrinol , vol.13 , pp. 251-258
    • Fletcher, T.P.1    Thomas, G.B.2    Clarke, I.J.3
  • 16
    • 0022389890 scopus 로고
    • Effects of rat growth hormone (rGH)-releasing factor and somatostatin on the release and synthesis of rGH in dispersed pituitary cells
    • Fukata J, Diamond DJ, Martin JB. Effects of rat growth hormone (rGH)-releasing factor and somatostatin on the release and synthesis of rGH in dispersed pituitary cells. Endocrinology 117: 457-467, 1985.
    • (1985) Endocrinology , vol.117 , pp. 457-467
    • Fukata, J.1    Diamond, D.J.2    Martin, J.B.3
  • 17
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human
    • Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19: 717-797, 1998.
    • (1998) Endocr Rev , vol.19 , pp. 717-797
    • Giustina, A.1    Veldhuis, J.D.2
  • 20
    • 0024556497 scopus 로고
    • Electron microscopic immunocytochemical evidence for the existence of bidirectional synaptic connections between growth hormone- and somatostatin-containing neurons in the hypothalamus of the rat
    • Horvath S, Palkovits M, Gorcs T, Arimura A. Electron microscopic immunocytochemical evidence for the existence of bidirectional synaptic connections between growth hormone- and somatostatin-containing neurons in the hypothalamus of the rat. Brain Res 481: 8-15, 1989.
    • (1989) Brain Res , vol.481 , pp. 8-15
    • Horvath, S.1    Palkovits, M.2    Gorcs, T.3    Arimura, A.4
  • 21
    • 75149186448 scopus 로고    scopus 로고
    • Preversus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: Studies using submaximal agonist drive and an estrogen clamp
    • Hudson SB, Schroeder DR, Bailey JN, Mielke KL, Erickson D, Miles JM, Bowers CY, Veldhuis JD. Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp. J Clin Endocrinol Metab 95: 353-360, 2010.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 353-360
    • Hudson, S.B.1    Schroeder, D.R.2    Bailey, J.N.3    Mielke, K.L.4    Erickson, D.5    Miles, J.M.6    Bowers, C.Y.7    Veldhuis, J.D.8
  • 22
    • 0022623768 scopus 로고
    • Growth hormone (GH)-releasing factor stimulates hypothalamic somatostatin release: An inhibitory feedback effect on GH secretion
    • Katakami H, Arimura A, Frohman LA. Growth hormone (GH)-releasing factor stimulates hypothalamic somatostatin release: an inhibitory feedback effect on GH secretion. Endocrinology 118: 1872-1877, 1986.
    • (1986) Endocrinology , vol.118 , pp. 1872-1877
    • Katakami, H.1    Arimura, A.2    Frohman, L.A.3
  • 23
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660, 2000.
    • (2000) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 25
    • 0034968209 scopus 로고    scopus 로고
    • Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
    • Low MJ, Otero-Corchon V, Parlow AF, Ramirez JL, Kumar U, Patel YC, Rubinstein M. Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth. J Clin Invest 107: 1571-1580, 2001.
    • (2001) J Clin Invest , vol.107 , pp. 1571-1580
    • Low, M.J.1    Otero-Corchon, V.2    Parlow, A.F.3    Ramirez, J.L.4    Kumar, U.5    Patel, Y.C.6    Rubinstein, M.7
  • 29
    • 0029853001 scopus 로고    scopus 로고
    • Central administration of a growth hormone (GH) receptor mRNA antisense increases GH pulsatility and decreases hypothalamic somatostatin expression in rats
    • Pellegrini E, Bluet-Pajot MT, Mounier F, Bennett P, Kordon C, Epelbaum J. Central administration of a growth hormone (GH) receptor mRNA antisense increases GH pulsatility and decreases hypothalamic somatostatin expression in rats. J Neurosci 16: 8140-8148, 1996.
    • (1996) J Neurosci , vol.16 , pp. 8140-8148
    • Pellegrini, E.1    Bluet-Pajot, M.T.2    Mounier, F.3    Bennett, P.4    Kordon, C.5    Epelbaum, J.6
  • 30
    • 0033932574 scopus 로고    scopus 로고
    • Irregularity and asynchrony in biologic network signals
    • Pincus SM. Irregularity and asynchrony in biologic network signals. Methods Enzymol 321: 149-182, 2000.
    • (2000) Methods Enzymol , vol.321 , pp. 149-182
    • Pincus, S.M.1
  • 32
    • 0035163242 scopus 로고    scopus 로고
    • Growth hormone (GH) rebound rise following somatostatin infusion withdrawal: Studies in dogs with the use of GHreleasing hormone and a GH-releasing peptide
    • Rigamonti AE, Cavallera G, Bonomo S, Deghenghi R, Locatelli V, Cella SG, Muller EE. Growth hormone (GH) rebound rise following somatostatin infusion withdrawal: studies in dogs with the use of GHreleasing hormone and a GH-releasing peptide. Eur J Endocrinol 145: 635-644, 2001.
    • (2001) Eur J Endocrinol , vol.145 , pp. 635-644
    • Rigamonti, A.E.1    Cavallera, G.2    Bonomo, S.3    Deghenghi, R.4    Locatelli, V.5    Cella, S.G.6    Muller, E.E.7
  • 33
    • 0025873042 scopus 로고
    • The growth hormone secretory pattern: A response to neuroendocrine signals
    • Robinson IC. The growth hormone secretory pattern: a response to neuroendocrine signals. Acta Paediatr Scand Suppl 372: 70-78, 1991.
    • (1991) Acta Paediatr Scand Suppl , vol.372 , pp. 70-78
    • Robinson, I.C.1
  • 34
    • 0034974980 scopus 로고    scopus 로고
    • Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: Evidence for a role for non-GHRH inputs into the generation of GH pulses
    • Roelfsema F, Biermasz NR, Veldman RG, Veldhuis JD, Frolich M, Stokvis-Brantsma WH, Wit JM. Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses. J Clin Endocrinol Metab 86: 2459-2464, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2459-2464
    • Roelfsema, F.1    Biermasz, N.R.2    Veldman, R.G.3    Veldhuis, J.D.4    Frolich, M.5    Stokvis-Brantsma, W.H.6    Wit, J.M.7
  • 35
    • 0027250099 scopus 로고
    • Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone and somatostatin gene expression in GH-deficient dwarf rats
    • Sato M, Frohman LA. Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone and somatostatin gene expression in GH-deficient dwarf rats. Endocrinology 133: 793-799, 1993.
    • (1993) Endocrinology , vol.133 , pp. 793-799
    • Sato, M.1    Frohman, L.A.2
  • 37
    • 34548722316 scopus 로고    scopus 로고
    • Age attenuates testosterone secretion driven by amplitude-varying pulses of recombinant human luteinizing hormone during acute gonadotrope inhibition in healthy men
    • Takahashi PY, Votruba P, Abu-Rub M, Mielke K, Veldhuis JD. Age attenuates testosterone secretion driven by amplitude-varying pulses of recombinant human luteinizing hormone during acute gonadotrope inhibition in healthy men. J Clin Endocrinol Metab 92: 3626-3632, 2007.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3626-3632
    • Takahashi, P.Y.1    Votruba, P.2    Abu-Rub, M.3    Mielke, K.4    Veldhuis, J.D.5
  • 38
    • 0037372024 scopus 로고    scopus 로고
    • Interrelationship between the novel peptide ghrelin, somatostatin and growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion
    • Tannenbaum GS, Epelbaum J, Bowers CY. Interrelationship between the novel peptide ghrelin, somatostatin and growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion. Endocrinology 144: 967-974, 2003.
    • (2003) Endocrinology , vol.144 , pp. 967-974
    • Tannenbaum, G.S.1    Epelbaum, J.2    Bowers, C.Y.3
  • 39
    • 15944418597 scopus 로고    scopus 로고
    • Testosterone blunts feedback inhibition of GH secretion by experimentally elevated IGF-I concentrations
    • Veldhuis JD, Anderson SM, Iranmanesh A, Bowers CY. Testosterone blunts feedback inhibition of GH secretion by experimentally elevated IGF-I concentrations. J Clin Endocrinol Metab 90: 1613-1617, 2005.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1613-1617
    • Veldhuis, J.D.1    Anderson, S.M.2    Iranmanesh, A.3    Bowers, C.Y.4
  • 40
    • 0036172467 scopus 로고    scopus 로고
    • Impact of estradiol supplementation on dual peptidyl drive of growth-hormone secretion in postmenopausal women
    • Veldhuis JD, Evans WS, Bowers CY. Impact of estradiol supplementation on dual peptidyl drive of growth-hormone secretion in postmenopausal women. J Clin Endocrinol Metab 87: 859-866, 2002.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 859-866
    • Veldhuis, J.D.1    Evans, W.S.2    Bowers, C.Y.3
  • 41
    • 0344011123 scopus 로고    scopus 로고
    • Estradiol supplementation enhances submaximal feedforward drive of growth hormone (GH) secretion by recombinant human GH-releasing hormone-1,44-amide in a putatively somatostatin-withdrawn milieu
    • Veldhuis JD, Evans WS, Bowers CY. Estradiol supplementation enhances submaximal feedforward drive of growth hormone (GH) secretion by recombinant human GH-releasing hormone-1,44-amide in a putatively somatostatin-withdrawn milieu. J Clin Endocrinol Metab 88: 5484-5489, 2003.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5484-5489
    • Veldhuis, J.D.1    Evans, W.S.2    Bowers, C.Y.3
  • 42
    • 18844373877 scopus 로고    scopus 로고
    • Testosterone and estradiol regulate free IGF-I, IGFBP-I and dimeric IGF-I/IGFBP-I concentrations
    • Veldhuis JD, Frystyk J, Iranmanesh A, Orskov H. Testosterone and estradiol regulate free IGF-I, IGFBP-I and dimeric IGF-I/IGFBP-I concentrations. J Clin Endocrinol Metab 90: 2941-2947, 2005.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2941-2947
    • Veldhuis, J.D.1    Frystyk, J.2    Iranmanesh, A.3    Orskov, H.4
  • 44
    • 0030882782 scopus 로고    scopus 로고
    • Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamosomatotrope (growth hormone)-insulin-like growth factor I axis in the human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement
    • Veldhuis JD, Metzger DL, Martha PM Jr, Mauras N, Kerrigan JR, Keenan B, Rogol AD, Pincus SM. Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamosomatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. J Clin Endocrinol Metab 82: 3414-3420, 1997.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3414-3420
    • Veldhuis, J.D.1    Metzger, D.L.2    Martha Jr., P.M.3    Mauras, N.4    Kerrigan, J.R.5    Keenan, B.6    Rogol, A.D.7    Pincus, S.M.8
  • 45
    • 62349124646 scopus 로고    scopus 로고
    • Aromatase and 5-alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex-steroid modulation of somatostatin and growth-hormone secretagogue actions in healthy older men
    • Veldhuis JD, Mielke KL, Cosma M, Soares-Welch C, Paulo R, Miles JM, Bowers CY. Aromatase and 5-alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex-steroid modulation of somatostatin and growth-hormone secretagogue actions in healthy older men. J Clin Endocrinol Metab 94: 973-981, 2009.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 973-981
    • Veldhuis, J.D.1    Mielke, K.L.2    Cosma, M.3    Soares-Welch, C.4    Paulo, R.5    Miles, J.M.6    Bowers, C.Y.7
  • 46
    • 33645517241 scopus 로고    scopus 로고
    • Somatotropic and gonadotropic axes linkages in infancy, childhood, and the pubertyadult transition
    • Veldhuis JD, Roemmich JN, Richmond EJ, Bowers CY. Somatotropic and gonadotropic axes linkages in infancy, childhood, and the pubertyadult transition. Endocr Rev 27: 101-140, 2006.
    • (2006) Endocr Rev , vol.27 , pp. 101-140
    • Veldhuis, J.D.1    Roemmich, J.N.2    Richmond, E.J.3    Bowers, C.Y.4
  • 47
    • 0034456786 scopus 로고    scopus 로고
    • Gender and sexual maturationdependent contrasts in the neuroregulation of growth hormone secretion in prepubertal and late adolescent males and females-a general clinical research center-based study
    • Veldhuis JD, Roemmich JN, Rogol AD. Gender and sexual maturationdependent contrasts in the neuroregulation of growth hormone secretion in prepubertal and late adolescent males and females-a general clinical research center-based study. J Clin Endocrinol Metab 85: 2385-2394, 2000.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2385-2394
    • Veldhuis, J.D.1    Roemmich, J.N.2    Rogol, A.D.3
  • 49
    • 0029805072 scopus 로고    scopus 로고
    • Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene
    • Woods KA, Camacho-Hubner C, Savage MO, Clark AJ. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med 335: 1363-1367, 1996.
    • (1996) N Engl J Med , vol.335 , pp. 1363-1367
    • Woods, K.A.1    Camacho-Hubner, C.2    Savage, M.O.3    Clark, A.J.4
  • 50
    • 0004252445 scopus 로고    scopus 로고
    • Upper Saddle River, NJ: Prentice Hall
    • Zar JH. Biostatistical Analysis. Upper Saddle River, NJ: Prentice Hall, 1996.
    • (1996) Biostatistical Analysis
    • Zar, J.H.1


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