Dysbalance of angiogenic and angiostatic mediators in patients with mixed connective tissue disease

Annals of the Rheumatic Diseases

Volumn 70, Issue 7, 2011, Pages 1197-1202

  Distler, Jörg H W ^a   Strapatsas, Tobias ^a   Huscher, Dörte ^b   Dees, Clara ^a   Akhmetshina, Alfiya ^a   Kiener, Hans P ^c   Tarner, Ingo H ^d,e   Maurer, Britta ^f   Walder, Marcel ^f   Michel, Beat ^f   Gay, Steffen ^f   Smolen, Josef S ^c   Müller Ladner, Ulf ^d,e   Schett, Georg ^a   Distler, Oliver ^f  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b German Rheumatism Research Centre   (Germany)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e KERCKHOFF HEART CENTER   (Germany)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; ENDOSTATIN; VASCULOTROPIN;

ACROSCLEROSIS; ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALE; MIXED CONNECTIVE TISSUE DISEASE; MYOSITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PULMONARY HYPERTENSION; SYSTEMIC SCLEROSIS; UPREGULATION; VOLUNTEER;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; ENDOSTATINS; FIBROBLAST GROWTH FACTOR 2; HUMANS; HYPERTENSION, PULMONARY; MIDDLE AGED; MIXED CONNECTIVE TISSUE DISEASE; MYOSITIS; SCLERODERMA, SYSTEMIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; YOUNG ADULT;

EID: 79957631782     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2010.140657     Document Type: Article

References (20)

1. Sharp GC, Irvin WS, Tan EM, et al. Mixed connective tissue disease - an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 1972;52:148-59.
2. Swanton J, Isenberg D. Mixed Connective Tissue Disease: Still Crazy After All These Years. Philadelphia, PA: Elsevier 2005.
3. Grader-Beck T, Wigley FM. Raynaud's phenomenon in mixed connective tissue disease. Rheum Dis Clin North Am 2005;31:465-81, vi.
4. Distler JH, Beyer C, Schett G, et al. Endothelial progenitor cells: novel players in the pathogenesis of rheumatic diseases. Arthritis Rheum 2009;60:3168-79.
5. Distler JH, Gay S, Distler O. Angiogenesis and vasculogenesis in systemic sclerosis. Rheumatology (Oxford) 2006;45(Suppl 3):iii26-7.
6. Koch AE, Distler O. Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis. Arthritis Res Ther 2007;9(Suppl 2):S3.
7. Distler JH, Hirth A, Kurowska-Stolarska M, et al. Angiogenic and angiostatic factors in the molecular control of angiogenesis. Q J Nucl Med 2003;47:149-61. (Pubitemid 37279152)
8. Dor Y, Djonov V, Abramovitch R, et al. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J 2002;21:1939-47. (Pubitemid 34437191)
9. Asahara T, Bauters C, Zheng LP, et al. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation 1995;92(9 Suppl):II365-71.
10. O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997;88:277-85. (Pubitemid 28015876)
11. Alarcon-Segovia D, Villarreal M. Diagnostic Criteria for MCTD. Philadelphia, PA: Elsevier 1987.
12. Alarcón-Segovia D, Cardiel MH. Comparison between 3 diagnostic criteria for mixed connective tissue disease. Study of 593 patients. J Rheumatol 1989;16:328-34. (Pubitemid 19104571)
13. Amigues JM, Cantagrel A, Abbal M, et al. Comparative study of 4 diagnosis criteria sets for mixed connective tissue disease in patients with anti-RNP antibodies. Autoimmunity Group of the Hospitals of Toulouse. J Rheumatol 1996;23:2055-62. (Pubitemid 27006751)
14. LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988;15:202-5. (Pubitemid 18073738)
15. Distler O, Del Rosso A, Giacomelli R, et al. Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res 2002;4:R11.
16. Kuwana M, Okazaki Y, Yasuoka H, et al. Defective vasculogenesis in systemic sclerosis. Lancet 2004;364:603-10. (Pubitemid 39094178)
17. Campbell A I, Zhao Y, Sandhu R, et al. Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension. Circulation 2001;104:2242-8. (Pubitemid 33043307)
18. Hebbar M, Peyrat JP, Hornez L, et al. Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis. Arthritis Rheum 2000;43:889-93.
19. Hummers LK, Hall A, Wigley FM, et al. Abnormalities in the regulators of angiogenesis in patients with scleroderma. J Rheumatol 2009;36:576-82.
20. Williams MH, Handler CE, Akram R, et al. Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension. Eur Heart J 2006;27:1485-94. (Pubitemid 43998084)