Design and evaluation of an easily fabricated micromixer with three-dimensional periodic perturbation

Chemical Engineering Journal

Volumn 171, Issue 1, 2011, Pages 291-300

  Lin, Ying ^a   Yu, Xinhai ^a   Wang, Zhenyu ^b   Tu, Shan Tung ^a   Wang, Zhengdong ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Fabrication; Micromixer; Mixing index; Simulation; Stretching; Villermaux Dushman method

Indexed keywords

CHAOTIC ADVECTION; ENHANCED MIXING; FLOW PATH; KEY VARIABLES; MECHANICAL PROCESSING; MICRO MIXERS; MICROMIXER; MIXING INDEX; MIXING QUALITY; PASSIVE MICROMIXER; PERIODIC PERTURBATION; RECIRCULATIONS; SIMULATION; SQUARE-WAVE; STRUCTURAL PARAMETER; VILLERMAUX/DUSHMAN METHOD;

COMPUTATIONAL FLUID DYNAMICS; FABRICATION; PERIODIC STRUCTURES; REYNOLDS NUMBER; THREE DIMENSIONAL;

MIXERS (MACHINERY);

EID: 79957627517     PISSN: 13858947     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cej.2011.04.003     Document Type: Article

References (26)

1. Nguyen N.T., Wu Z.G. Micromixers-a review. J. Micromech. Microeng. 2005, 15:R1-R16.
2. Ismagilov R.F., Stroock A.D., Kenis P.J.A., Whitesides G., Stone H.A. Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels. Appl. Phys. Lett. 2000, 76:2376-2378.
3. Kamholz A.E., Weigl B.H., Finlayson B.A., Yager P. Quantitative analysis of molecular interaction in a microfluidic channel: the T-sensor. Anal. Chem. 1999, 71:5340-5347.
4. Knight J.B., Vishwanath A., Brody J.P., Austin R.H. Hydrodynamic focusing on a silicon Chip: mixing nanoliters in microseconds. Phys. Rev. Lett. 1998, 80:3863-3866.
5. Bessoth F.G., deMello A.J., Manz A. Microstructure for efficient continuous flow mixing. Anal. Commun. 1999, 36:213-215.
6. Munson M.S., Yager P. Simple quantitative optical method for monitoring the extent of mixing applied to a novel microfluidic mixer. Anal. Chim. Acta 2004, 507:63-71.
7. Voldman J., Gray M.L., Schmidt M.A. An integrated liquid mixer/valve. J. Microelectromech. Syst. 2000, 9:295-302.
8. Hosokawa K., Fujii T., Endo I. IEEE. Mems'99: Twelfth IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest 1999, 388-393.
9. Mengeaud V., Josserand J., Girault H.H. Mixing processes in a zigzag microchannel: finite element simulations and optical study. Anal. Chem. 2002, 74:4279-4286.
10. Egawa T., Durand J.L., Hayden E.Y., Rousseau D.L., Yeh S.R. Design and evaluation of a passive alcove-based microfluidic mixer. Anal. Chem. 2009, 81:1622-1627.
11. Hong C.C., Choi J.W., Ahn C.H. A novel in-plane passive microfluidic mixer with modified Tesla structures. Lab Chip 2004, 4:109-113.
12. Liu R.H., Stremler M.A., Sharp K.V., Olsen M.G., Santiago J.G., Adrian R.J., Aref H., Beebe D.J. Passive mixing in a three-dimensional serpentine microchannel. J. Microelectromech. Syst. 2000, 9:190-197.
13. Stroock A.D., Dertinger S.K.W., Ajdari A., Mezic I., Stone H.A., Whitesides G.M. Chaotic mixer for microchannels. Science 2002, 295:647-651.
14. Kim D.S., Lee S.H., Kwon T.H., Ahn C.H. A serpentine laminating micromixer combining splitting/recombination and advection. Lab Chip 2005, 5:739-747.
15. Lee J., Kwon S. Mixing efficiency of a multilamination micromixer with consecutive recirculation zones. Chem. Eng. Sci. 2009, 64:1223-1231.
16. Tofteberg T., Skolimowski M., Andreassen E., Geschke O. A novel passive micromixer: lamination in a planar channel system. Microfluid. Nanofluid. 2010, 8:209-215.
17. Hardt S., Drese K.S., Hessel V., Schonfeld F. Passive micromixers for applications in the microreactor and μTAS fields. Microfluid. Nanofluid. 2005, 1:108-118.
18. Jeong G.S., Chung S., Kim C.B., Lee S.H. Applications of micromixing technology. Analyst 2010, 135:460-473.
19. Nguyen N.T., Huang X.Y. Modelling, fabrication and characterization of a polymeric micromixer based on sequential segmentation. Biomed. Microdevices 2006, 8:133-139.
20. Nguyen N.T, Huang X.Y. Mixing in microchannels based on hydrodynamic focusing and time-interleaved segmentation: modelling and experiment. Lab Chip 2005, 5:1320-1326.
21. Fournier M.C., Falk L., Villermaux J. A new parallel competing reaction system for assessing micromixing efficiency-determination of micromixing time by a simple mixing model. Chem. Eng. Sci. 1996, 51:5187-5192.
22. Palmer D.A., Ramette R.W., Mesmer R.E. Triiodide ion formation equilibrium and activity coefficients in aqueous solution. J. Solut. Chem. 1984, 13:673-683.
23. Panic S., Loebbecke S., Tuercke T., Antes J., Boskovic D. Experimental approaches to a better understanding of mixing performance of microfluidic devices. Chem. Eng. J. 2004, 101:409-419.
24. Aoki N., Mae K. Effects of channel geometry on mixing performance of micromixers using collision of fluid segments. Chem. Eng. J. 2006, 118:189-197.
25. Falk L., Commenge J.M. Performance comparison of micromixers. Chem. Eng. Sci. 2010, 65:405-411.
26. Kashid M., Renken A., Kiwi-Minsker L. Mixing efficiency and energy consumption for five generic microchannel designs. Chem. Eng. J. 2011, 167:436-443.