Impact of gavage dosing procedure and gastric content on adverse respiratory effects and mortality in rat toxicity studies

Journal of Applied Toxicology

Volumn 31, Issue 4, 2011, Pages 342-354

  Eichenbaum, G ^a   Damsch, S ^b   Looszova, A ^b   Vandenberghe, J ^b   Van den Bulck, K ^b   Roels, K ^b   Megens, A ^b   Knight, E ^a   Hillsamer, V ^a   Feyen, B ^b   Kelley, M F ^a   Tonelli, A ^a   Lammens, L ^b  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Dosing error; Gastric emptying; Gavage; Mortality; Rat; Respiratory effect

Indexed keywords

COMPOUND X; HYPERTONIC SOLUTION; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DYSPNEA; FEEDING; GASTROESOPHAGEAL REFLUX; HISTOPATHOLOGY; MALE; MORTALITY; NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECURRENT DISEASE; RESPIRATORY TRACT INFLAMMATION; STOMACH CONTENT;

ADMINISTRATION, ORAL; ANIMALS; DYSPNEA; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL CONTENTS; INJECTIONS, INTRAVENOUS; INTUBATION, GASTROINTESTINAL; MALE; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RESPIRATORY ASPIRATION; TOXICITY TESTS;

ANIMALIA; RATTUS;

EID: 79957605235     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1592     Document Type: Article

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