Localization of apoptosis proteins and lymphocyte subsets in chronic rejection of human liver allograft

Interventional Medicine and Applied Science

Volumn 2, Issue 2, 2010, Pages 77-84

  Nemes, B ^a   Sotonyi P ^a   Lotz, G ^a   Heratizadeh, A ^b   Gelley, F ^a   Doege, C ^c   Hubay, M ^a   Schaff, Zs ^a   Nashan, B ^d  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d DALHOUSIE UNIVERSITY   (Canada)

Author keywords

apoptosis; Bax; Bcl 2; biliary; chronic rejection; Fas; fatty liver; liver transplantation; TNF alpha

Indexed keywords

EID: 79957602856     PISSN: 20611617     EISSN: 20615094     Source Type: Journal    
DOI: 10.1556/IMAS.2.2010.2.6     Document Type: Article

References (45)

1. Kerr JF, Wyillie AH, Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26, 239-257 (1972)
2. Syn WK, Choi SS, Diehl AM: Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis 13, 565-580 (2009)
3. Nakanuma Y, Harada K, Sato Y, Ikeda H: Recent progress in ethiopathogenesis of pediatric biliary disease, particularly Caroli's disease with congenital hepatic fibrosis and biliary atresia. Histol Histopathol 25, 223-235 (2010)
4. Nakanuma Y, Tsuneyama K, Harada K: Pathology and pathogenesis of the intrahepatic bile duct loss. J Hepatobiliary Pancreat Surg 8, 303-315 (2001)
5. Tannapfel A, Kohlhaw K, Ebelt J et al.: Apoptosis and the expression of Fas and Fas-ligand (FasL) antigen in rejection and reinfection in liver allograft specimens. Transplantation 67, 1079-1083 (1999)
6. Wang J, Li W, Min J, Ou Q et al.: Intrasplenic transplantation of allogeneic hepatocytes modified by BCL-2 gene protects rats from acute liver failure. Transplant Proc 36, 2924-2926 (2004)
7. Afford SC, Ahmed-Choudhury J, Randhawa S et al.: CD-40 activation-induced Fas-dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cells. FASEB 15, 2345-2354 (2001)
8. Afford SC, Randhava S, Eliopulos AG, Hubscher SG, Young LS, Adams DH: CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface Fas ligand expression and amplifies Fas-mediated hepatocyte death during allograft rejection. J Exp Med 189, 441-446 (1999)
9. Bai J, Odin JA: Apoptosis and the liver: relation to autoimmunity and related conditions. Autoimmunity Review 2, 36-42 (2003)
10. Koukoulis GK, Shen J, Karademir S, Jensen D, Williams J: Cholangiocytic apoptosis in chronic ductopenic rejection. Human Pathology 32, 823-827 (2001)
11. Malhi H, Gores GJ, Lemasters JJ: Apoptosis and necrosis in the liver: A tale of two deaths? Hepatology 43 (2 Suppl 1), s31-s44 (2006)
12. Warle MC, Farhan A, Metselaar H et al.: Cytokine gene polymorphism and acute human liver graft rejection. Liver Transpl 8, 603-611 (2002)
13. Krams SM, Egawa H, Quinn MB, Villanueva, Garcia-Kennedy R, Martinez OM: Apoptosis as a mechanism of cell death in liver allograft rejection. Transplantation 59, 621-625 (1995)
14. Gollacker B, Sedivy R, Rockenschaub S et al.: Increased apoptosis of hepatocytes in vascular occlusion after orthotopic liver transplantation. Transplant Int. 13, 49-53 (2000)
15. Demirci G, Nashan B, Pichlmayr R: Fibrosis in chronic rejection of human liver allografts. Transplantation 62, 1776-1783 (1996)
16. Kemnitz J, Gubernatis G, Bunzendahl H, Ringe B, Pichlmayr R, Georgii A: Criteria for the histopathological classification of liver allograft rejection and their clinical relevance. Transplant Proc 21, 2208-2210 (1989)
17. Van Hoek B, Wiesner RH, Krom RAF, Ludwig J, Moore SB: Severe ductopenic rejection after liver transplantation: incidence, time of onset, risk factors, treatment and outcome. Semin Liver Dis 12, 41-50 (1992)
18. Ludwig J: Classification and terminology of hepatic allograft rejection: Whiter bound? Mayo Clin Proc 64, 676-679 (1989)
19. Ludwig J, Wiesner RH, Battas KP, Perkins JD, Krom RA: The acute vanishing bile duct syndrome (acute irreversible rejection) after orthotopic liver transplantation. Hepatology 7, 476-483 (1987)
20. Lotz G, Simon S, Patonai A et al.: Detection of Chlamydia pneumoniae in liver transplant patients with chronic allograft rejection. Transplantation 77, 1522-1528 (2004)
21. Demirci G, Hoshino K, Nashan B: Expression patterns of integrin receptors and extracellular matrix proteins in chronic rejection of human liver allograft. Transplant Immunology 7, 229-237 (1999)
22. Sebagh M, Blakolmer K, Falissard B et al.: Accuracy of bile duct changes for the diagnosis of chronic liver allograft rejection: Reliability of the 1999 Banff schema. Hepatology 35, 117-125 (2002)
23. Neil DA, Hubscher SG: Histologic and biochemical changes during the evolution of chronic rejection of liver allografts. Hepatology 35, 639-651 (2002)
24. Backman L, Gibbs J, Levy M et al.: Causes of late graft loss after liver transplantation. Transplantation 55, 1078-1082 (1993)
25. Evans PC, Smith S, Hirschfield G et al.: Recipient HLA-DR3, tumour necrosis factor-alpha promoter allele-2 (tumour necrosis factor-2) and cytomegalovirus infection are inter-related risk factors for chronic rejection of liver allograft. J Hepatol 34, 711-715 (2001)
26. Desai M, Neuberger J: Chronic liver allograft dysfunction. Transplant Proc 41, 773-776 (2009)
27. Neil DA, Hubscher SG: Histologic and biochemical changes during the evolution of chronic rejection of liver allografts. Hepatology 35, 639-651 (2002)
28. Miloh T, Magid MS, Iyer K et al.: Chronic rejection preceded by central perivenulitis, rapidly ensuring after liver transplantation in a pediatric patient. Semin Liver Dis 29, 134-138 (2009)
29. Scoazec JY: Expression of cell-matrix adhesion molecules in the liver and their modulation during fibrosis. J Hepatol 22 (2 Suppl), 20-27 (1995)
30. Oguma S, Belle S, Starzl TE, Demetris AJ: A histometric analysis of chronically rejected human liver allografts: insights into the mechanisms of bile duct loss: direct immunologic and ischemic factors. Hepatology 9, 204-209 (1989)
31. Jain D, Robert ME, Navarro V, Friedman AL, Crawford JM: Total fibrous obliteration of main portal vein and portal foam cell venopathy in chronic hepatic allograft rejection. Arch Pathol Lab Med 128, 64-67 (2004)
32. Davidson M, Kuo CC, Middaugh JP et al.: Confirmed previous infection with Chlamydia pneumoniae (TWAR) and its presence in early coronary atherosclerosis. Circulation 98, 628-633 (1998)
33. Gupta S, Camm AJ: Chlamydia pneumoniae, antimicrobial therapy and coronary heart disease: a critical overview. Coron Artery Dis 9, 339-343 (1998)
34. Blessing E, Kuo CC, Lin TM et al.: Foam cell formation inhibits growth of Chlamydia pneumoniae but does not attenuate Chlamydia pneumoniae-induced secretion of proinflammatory cytokines. Circulation 105, 1976-1982 (2002)
35. Celli A, Que FG: Dysregulation of apoptosis in the cholangiopathies and cholangiocarcinoma. Semin Liver Dis 18, 177-185 (1998)
36. Harada K, Furubo S, Ozaki S et al.: Increased expression of WAF1 in intrahepatic bile ducts in primary biliary cirrhosis relates to apoptosis. J Hepatol 34, 500-506 (2001)
37. Hayashi M, Martinez OM, Garcia-Kennedy R, So S, Esquivel CO, Krams SM: Expression of cytokines and immune mediators during chronic liver allograft rejection. Transplantation 60, 1533-1538 (1995)
38. Harada K, Nakanuma Y: Intrahepatic bile duct loss in immunemediated ductopenic biliary diseases with an emphasis on biliary epithelial apoptosis. Minerva Gastroenterol Dietol 49, 41-51 (2003)
39. Gapany C, Zhao M, Zimmermann A: The apoptosis protector, Bcl2 protein is downregulated in bile duct epithelial cells of human liver allografts. J Hepatol 26, 535-542 (1997)
40. Patel T, Tores GJ: Apoptosis and hepatobiliary disease. Hepatology 18, 105-114 (1995)
41. Leij van der J, Berg van den A, Albrecht EWJA et al.: High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells. Transplantation 75, 2076-2082 (2003)
42. Gouw AS, van den Heuvel MC, van den Berg AP et al.: The significance of parenchymal changes of acute cellular rejection in predicting chronic liver graft rejection. Transplantation 73, 243-247 (2002)
43. Töx U, Burkhardt MA, Benz C et al.: Expression of apoptosis and apoptosis-related peptides in various stages of rejection in the human transplanted liver. Hepatogastroenterology 48, 1697-1700 (2001)
44. van den Heuvel MC, de Jong KP, Boot M et al.: Preservation of bile ductules mitigates bile duct loss. Am J Transplant 6, 2660-2671 (2006)
45. Chunbin Zou, Jihong Ma, Xue Wang et al.: Lack of Fas antagonism by Met in human fatty liver disease. Nature Medicine 13, 1078-1085 (2007)