Investigation into the mechanism(s) of antithrombotic effects of carbon monoxide releasing molecule-3 (CORM-3)

Thrombosis Research

Volumn 127, Issue 6, 2011, Pages 551-559

  Soni, Hitesh ^a,b   Jain, Mukul ^a   Mehta, Anita A ^b  

^a ZYDUS RESEARCH CENTRE   (India)

^b GUJARAT UNIVERSITY   (India)

Author keywords

Antithrombotic; Carbon monoxide; CORM 3; Nitric oxide; Platelet; Rat; Soluble guanylate cyclase

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CARBON MONOXIDE; CARBON MONOXIDE RELEASING MOLECULAR 3; CLOPIDOGREL; GLIBENCLAMIDE; GUANYLATE CYCLASE; MITOGEN ACTIVATED PROTEIN KINASE 14; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; TALMAPIMOD; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTERIOVENOUS SHUNT; ARTERY THROMBOSIS; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

ANIMALS; ANTITHROMBINS; BLOOD PLATELETS; CARBON MONOXIDE; DISEASE MODELS, ANIMAL; HUMANS; MALE; ORGANOMETALLIC COMPOUNDS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET AGGREGATION; RATS; RATS, WISTAR; THROMBIN; THROMBOSIS;

EID: 79957597775     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.02.009     Document Type: Article

References (34)

1. Chance B, Erecinska M, Wagner M. Mitochondrial responses to carbon monoxide toxicity. Ann NY Acad Sci 1970;174:193-204.
2. Otterbein LE, Soares MP, Yamashita K, Bach FH. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol 2003;24:449-55. (Pubitemid 36928103)
3. Morita T, Perrella MA, Lee ME, Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci USA 1995;92:1475-9.
4. Wang R, Wang Z, Wu L. Carbon monoxide-induced vasorelaxation and the underlying mechanisms. Br J Pharmacol 1997;121:927-34. (Pubitemid 27277786)
5. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res 2002;90:E17-24.
6. Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, et al. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ Res 2003;93:E2-8.
7. Soni H, Patel P, Rath AC, Jain M, Mehta AA. Cardioprotective effect with carbon monoxide releasing molecule-2 (CORM-2) in isolated perfused rat heart: Role of coronary endothelium and underlying mechanism. Vascul Pharmacol 2010;53:68-76.
8. Marshall M, Hess H. Acute effects of low carbon monoxide concentrations on blood rheology, platelet fuction and the arterial wall in the minipig. Res Exp Med (Berl) 1981;178:201-10. (Pubitemid 11096726)
9. Mansouri A, Perry CA. Inhibition of platelet ADP and serotonin release by carbon monoxide and in cigarette smokers. Experientia 1984;40:515-7. (Pubitemid 14096265)
10. Brune B, Ullrich V. Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol Pharmacol 1987;32:497-504. (Pubitemid 18006150)
11. Wagner CT, Durante W, Christodoulides N, Hellums JD, Schafer AI. Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells. J Clin Invest 1997;100:589-96. (Pubitemid 27340506)
12. Morisaki H, Katayama T, Kotake Y, Ito M, Tamatani T, Sakamoto S, et al. Roles of carbon monoxide in leukocyte and platelet dynamics in rat mesentery during sevoflurane anesthesia. Anesthesiology 2001;95:192-9. (Pubitemid 32623013)
13. Sato K, Balla J, Otterbein LE, Smith RN, Brouard S, Lin Y, et al. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol 2001;166:4185-94. (Pubitemid 32224952)
14. Peng L, Mundada L, Stomel JM, Liu JJ, Sun J, Yet SF, et al. Induction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis. Antioxid Redox Signal 2004;6:687-90.
15. Fujita T, Toda K, Karimova A, Yan S-F, Naka Y, Yet SF, et al. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med 2001;7:598-604. (Pubitemid 32448328)
16. Chen B, Guo L, Fan C, Bolisetty S, Joseph R, Wright MM, et al. Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation. Am J Pathol 2009;175:422-9.
17. Chlopicki S, Olszanecki R, Marcinkiewicz E, Lomnicka M, Motterlini R. Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase. Cardiovasc Res 2006;71:393-401. (Pubitemid 43949260)
18. Fratantoni JC, Poindexter BJ. Measuring platelet aggregation with microplate reader. A new technical approach to platelet aggregation studies. Am J Clin Pathol 1990;94:613-7. (Pubitemid 20369725)
19. Soni H, Sharma A, Bhatt S, Jain MR, Patel PR. Antithrombotic effects due to pharmacological modulation of thrombin-activatable fibrinolysis inhibitor in rats. Pharmacology 2008;82:304-9.
20. Wong PC, Crain Jr EJ, Nguan O, Watson CA, Racanelli A. Antithrombotic actions of selective inhibitors of blood coagulation factor Xa in rat models of thrombosis. Thromb Res 1996;83:117-26. (Pubitemid 26274429)
21. Gustafsson D, Nyström J, Carlsson S, Bredberg U, Eriksson U, Gyzander E, et al. The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects. Thromb Res 2001;101:171-81. (Pubitemid 32176022)
22. Peternel L, Drevensek G, Cerne M, Stalc A, Stegnar M, Budihna MV. Evaluation of two experimental venous thrombosis models in the rat. Thromb Res 2005;115:527-34. (Pubitemid 40409987)
23. Dejana E, Callioni A, Quintana A, de Gaetano G. Bleeding time in laboratory animals. II - A comparison of different assay conditions in rats. Thromb Res 1979;15:191-7.
24. Andrews RK, Berndt MC. Platelet physiology and thrombosis. Thromb Res 2004;114:447-53. (Pubitemid 39422578)
25. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-42.
26. Lindenblatt N, Bordel R, Schareck W, Menger MD, Vollmar B. Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo. Arterioscler Thromb Vasc Biol 2004;24:601-6. (Pubitemid 38326159)
27. Otterbein LE, Zuckerbraun BS, Haga M, Liu F, Song R, Usheva A, et al. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med 2003;9:183-90. (Pubitemid 36227720)
28. Brune B, Schmidt KU, Ullrich V. Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion. Eur J Biochem 1990;192:683-8. (Pubitemid 20316870)
29. Friebe A, Mullershausen F, Smolenski A, Walter U, Schultz G, Koesling D. YC-1 potentiates nitric oxide- and carbon monoxideinduced cyclic GMP effects in human platelets. Mol Pharmacol 1998;54:962-7. (Pubitemid 29002038)
30. Motterlini R, Mann BE, Johnson TR, Clark JE, Foresti R, Green CJ. Bioactivity and pharmacological actions of carbon monoxide-releasing molecules. Curr Pharm Des 2003;9:2525-39. (Pubitemid 37236371)
31. Foresti R, Hoque M, Bains S, Green CJ, Motterlini R. Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway. Biochem J 2003;372:381-90. (Pubitemid 36723883)
32. Sawle P, Foresti R, Mann BE, Johnson TR, Green CJ, Motterlini R. Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br J Pharmacol 2005;145: 800-10. (Pubitemid 41076287)
33. Thom SR, Xu YA, Ischiropoulos H. Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure. Chem Res Toxicol 1997;10:1023-31. (Pubitemid 27418019)
34. Cardell LO, Ueki IF, Stjärne P, Agusti C, Takeyama K, Lindén A, et al. Bronchodilatation in vivo by carbon monoxide, a cyclic GMP related messenger. Br J Pharmacol 1998;124:1065-8. (Pubitemid 28333926)