Bioactive porous beads as an injectable urethral bulking agent: In vivo animal study for the treatment of urinary incontinence

Tissue Engineering - Part A

Volumn 17, Issue 11-12, 2011, Pages 1527-1535

  Kim, In Gul ^a,b   Oh, Se Heang ^a   Lee, Ji Young ^b   Lee, Ji Youl ^b   Lee, Jin Ho ^a  

^a Hannam University   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; CELL CULTURE; LEACHING; MUSCLE; POLYCAPROLACTONE;

ANIMAL MODEL; ANIMAL STUDIES; BASIC FIBROBLAST GROWTH FACTOR; BULKING AGENTS; CURE BEHAVIOR; GROWTH FACTOR; HEPARIN BINDING; IN-VIVO; PORE SURFACE; SMOOTH MUSCLES; SPRAGUE-DAWLEY RATS; STRESS URINARY INCONTINENCES; URINARY INCONTINENCE; VASCULAR ENDOTHELIAL GROWTH FACTOR;

PEPTIDES;

ANIMALIA; RATTUS;

BIOMATERIAL; IMMOBILIZED PROTEIN; MICROSPHERE; POLOXAMER; POLYCAPROLACTONE; POLYESTER; SIGNAL PEPTIDE;

ANIMAL; ARTICLE; DRUG EFFECT; ELECTROPHYSIOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INJECTION; MUSCLE CONTRACTION; PATHOLOGY; PATHOPHYSIOLOGY; POROSITY; PRESSURE; RAT; SCANNING ELECTRON MICROSCOPY; SPRAGUE DAWLEY RAT; URETHRA; URINE INCONTINENCE;

ANIMALS; BIOCOMPATIBLE MATERIALS; ELECTROPHYSIOLOGICAL PHENOMENA; IMMOBILIZED PROTEINS; IMMUNOHISTOCHEMISTRY; INJECTIONS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MUSCLE CONTRACTION; POLOXAMER; POLYESTERS; POROSITY; PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; URETHRA; URINARY INCONTINENCE;

EID: 79957582499     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2010.0600     Document Type: Article

References (32)

1. Hampel, C., Wienhold, D., Benken, N., Eggersmann, C., and Thuroff, J.W. Prevalence and natural history of female incontinence. Eur Urol 32 (suppl 2), 3, 1997.
2. Blaivas, J.G., and Olsson, C.A. Stress incontinence: classification and surgical approach. J Urol 139, 727, 1988.
3. Perucchini, D., DeLancey, J.O., Ashton-Miller, J.A., Peschers, U., and Katria, T. Age effects on urethral striated muscle. I. Changes in number and diameter of striated muscle fibers in the ventral urethral. Am J Obstet Gynecol 186, 351, 2002.
4. Schick, E., Tessier, J., Bertrand, P.E., Dupont, C., and Jolivet-Tremblay, M. Observations on the function of the female urethral. I. Relation between maximum urethral closure pressure at rest and urethral hypermobility. Neurourol Urodyn 22, 643, 2003.
5. Pandit, M., DeLancey, J.O., Ashton-Miller, J.A., Iyengar, J., Blaivas, M., and Perucchini, D. Quantification of intramuscular nerves within the female striated urogenital sphincter muscle. Obstet Gynecol 95, 797, 2000.
6. Peschers, U., Schaer, G., Anthuber, C., DeLancey, J.O., and Schuessler, B. Changes in vesical neck mobility following vaginal delivery. Obstet Gynecol 88, 1001, 1996.
7. Thom, D.H., Van Den Eeden, S.K., and Brown, J.S. Evaluation of parturition and other reproductive variables as risk factors for urinary incontinence in later life. Obstet Gynecol 90, 983, 1997.
8. Meyer, S., De Grandi, P., Schreyer, A., and Caccia, G. The assessment of bladder neck position and mobility in continent nullipara mulitpar, forceps-derived and incontinent women using perineal ultrasound: a future office procedure? Int Urogynecol J Pelvic Floor Dysfunct 7, 138, 1996.
9. Rovner, E.S., and Wein, A.J. Treatment options for stress urinary incontinence. Rev Urol 6 (suppl 3), 29, 2004.
10. Dmochowski, R.R., and Appell, R.A. Injectable agents in the treatment of stress urinary incontinence in women: where are we now? Urology 56 (suppl 6A), 32, 2000.
11. Alcalay, M., Monga, Q.A., and Stanton, S.L. Burch colposuspension: a 10-20 year follow up. Br J Obstet Gynaecol 102, 740, 1995.
12. McGuire, E.J., and Gormley, E.A. Abdominal fascial slings. In: Rax, S., ed. Female Urology, 2nd ed. Philadelphia, PA: W.B. Saunders, 1996, pp. 369-381.
13. Madjar, S., Jacoby, K., Giberti, C., Wald, M., Halachmi, S., Issaq, E., Moskivitz, B., Beyar, M., and Nativ, O. Bone anchored sling for the treatment of post-prostatectomy incontinence. J Urol 165, 72, 2001.
14. Feki, A., Faltin, D.L., Lei, T., Dubuisson, J.B., Jacob, S., and Irion, O. Sphincter incontinence: is regenerative medicine the best alternative to restore urinary or anal sphincter function? Int J Biochem Cell B 39, 678, 2007.
15. Jankowski, R., Pruchnic, R., Wagner, D., and Chancellor, M.B. Regenerative therapy for stress urinary incontinence. Tzu Chi Med J 20, 169, 2008.
16. Yokoyama, T., Pruchnic, R., Lee, J.Y., Chuang, Y.C., Jumon, H., Yoshimura, N., de Groat, W.C., Huard, J., and Chancellor, M.B. Autologous primary muscle-derived cells transfer into the lower urinary tract. Tissue Eng 7, 395, 2001.
17. Lee, J.Y., Cannon, T.W., Pruchnic, R., Fraser, M.O., Huard, J., and Chancellor, M.B. The effects of periurethral musclederived stem cell injection on leak point pressure in a rat model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 14, 31, 2003.
18. Cannon, T.W., Lee, J.Y., Somogyi, G., Pruchnic, R., Smith, C.P., Huard, J., and Chancellor, M.B. Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra. Urology 62, 958, 2003.
19. Chermansky, C.J., Tarin, T., Kwon, D.D., Jankowski, R.J., Cannon, T.W., de Groat, W.C., Huard, J., and Chancellor, M.B. Intraurethral muscle-derived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency. Urology 63, 780, 2004.
20. Strasser, H., Marksteiner, R., Margreiter, E., Pinggera, G.M., Mitterberger, M., Fritsch,H., Klima, G., Radler, C., Stadlbauer, K.H., Fussenegger, M., Hering, S., and Bartsch, G. Stem cell therapy for urinary incontinence. Urologe A 43, 1237, 2004.
21. Jack, G.S., Almeida, F.G., Zhang, R., Alfonso, Z.C., Zuk, P.A., and Rodriguez, L.V. Processed lipoaspirate cells for tissue engineering of the lower urinary tract: Implications for the treatment of stress urinary incontinence and bladder reconstruction. J Urol 174, 2041, 2005.
22. Yiou, R., Lefaucheur, J.P., and Atala, A. The regeneration process of the striated urethral sphincter involves activation of intrinsic satellite cells. Anat Embryol (Berl) 206, 429, 2003.
23. Yiou, R., Yoo, J.J., and Atala, A. Restoration of functional motor units in a rat model of sphincter injury by muscle precursor cell autografts. Transplantation 76, 1053, 2003.
24. Takahashi, S., Chen, Q., Ogushi, T., Fujimura, T., Kumagai, J., Matsumoto, S., Hijikata, S., Tabata, Y., and Kitamura, T. Periurethral injection of sustained release basic fibroblast growth factor improves sphincteric contractility of the rat urethra denervated by botulinum-a toxin. J Urol 176, 819, 2006.
25. Oh, S.H., Kim, I.G., Lee, J.Y., Lee, J.Y., and Lee, J.H. Bioactive porous beads as an injectable urethral bulking agent: their in vitro evaluation on smooth muscle cell differentiation. Tissue Eng Part A 17, 655, 2011.
26. Lim, S.M., Lee, H.J., Oh, S.H., Kim, J.M., and Lee, J.H. Novel fabrication of PCL porous beads for use as an injectable cell carrier system. J Biomed Mater Res 90B, 521, 2009.
27. Lim, S.M., Jang, S.H., Oh, S.H., Yuk, S.H., Im, G.I., and Lee, J.H. Dual growth factor-releasing PCL scaffolds for chondrogenesis of adipose tissue-derived mesenchymal stem cells. Adv Eng Mater 12, B62, 2010.
28. Chermansky, C.J., Cannon, T.W., Torimoto, K., Fraser, M.O., Yoshimura, N., de Groat, W.C., and Chancellor, M.B. A model of intrinsic sphincteric deficiency in the rat: electrocauterization. Neurourol Urodyn 23, 166, 2004.
29. Oh, S.H., Kim, J.K., Song, K.S., Noh, S.M., Ghil, S.H., Yuk, S.H., and Lee, J.H. Prevention of postsurgical tissue adhesion by anti-inflammatory drug-loaded pluronic mixtures with sol-gel transition behavior. J Biomed Mater Res 72A, 306, 2005.
30. Carmeliet, P. Mechanism of angiogenesis and atreriogenesis. Nat Med 6, 389, 2000.
31. Lindner, V., and Reidy, M.A. Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries an en face study. Circ Res 73, 589, 1993.
32. Liu, X., Lin, C.S., Graziottin, T., Resplande, J., and Lue, T.F. Vascular endothelial growth factor promotes proliferation and migration of cavernous smooth muscle cells. J Urol 166, 354, 2001.