CsF mediated rapid condensation of 1,3-cyclohexadione with aromatic aldehydes: Comparative study of conventional heating vs. ambient temperature

Chinese Chemical Letters

Volumn 22, Issue 7, 2011, Pages 777-780

  Nandre, Kamalakar P ^a   Patil, Vijay S ^a   Bhosale, Sidhanath V ^a  

^a NORTH MAHARASHTRA UNIVERSITY   (India)

Author keywords

1,3 Cyclohexadione; Aromatic aldehydes; Cesium fluoride

Indexed keywords

EID: 79957533615     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2011.01.002     Document Type: Article

References (30)

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28. General method for synthesis of (3): A mixture of an aromatic aldehyde (1.0 mmol), 1,3-cyclohexadionone (2.0 mmol) and 10 mol% CsF in ethanol (10 mL) was stirred at room temperature for 15-35 min. The progress of the reaction was monitored by thin-layer chromatography, TLC (eluent, ethyl acetate-hexane 1:1) after completion of the reaction, the white solid precipitated out from ethanol, filtered, washed with water (25 mL) and purified by recrystallization from ethanol.
29. General method for synthesis of (4): A mixture of an aromatic aldehyde (1.0 mmol), 1,3-cyclohexadionone (2.0 mmol) and 10 mol% CsF in ethanol (10 mL) was heated at 80 °C for 60-120 min. The progress of the reaction was monitored by thin-layer chromatography, TLC (eluent, ethyl acetate-hexane 2:1) after completion of the reaction, ethanol was removed by reduced pressure. Suspended white solid in 3 mol/L HCl, filtered, washed with water (25 mL) and purified by recrystallization from ethanol.
30. +); white solid; M.P. 200-202 °C.