A bilateral cicatricial ectropion and bilateral upper lid shortening caused by 5-fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency

Cutaneous and Ocular Toxicology

Volumn 30, Issue 2, 2011, Pages 157-159

  Obi, Ebube E ^a   McDonald, Alec ^b   Kemp, Ewan ^a  

^a GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

^b BEATSON WEST OF SCOTLAND CANCER CENTRE   (United Kingdom)

Author keywords

Capecitabine; chemotherapy; conjunctivtis; ectropion, 5 fluorouracil; fluoropyrimidines; keratitis; mucositis; toxicity

Indexed keywords

CAPECITABINE; CARBOXYMETHYLCELLULOSE; CHLORAMPHENICOL; FLUCONAZOLE; GENTAMICIN; GRANULOCYTE COLONY STIMULATING FACTOR; LACRILUBE; LANSOPRAZOLE; LUBRICATING AGENT; NYSTATIN; PIPERACILLIN PLUS TAZOBACTAM; UNCLASSIFIED DRUG;

ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CASE REPORT; CHEMORADIOTHERAPY; DIARRHEA; DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY; DIZZINESS; DRUG WITHDRAWAL; ECTROPION; EYELID CLOSURE; EYELID DISEASE; FACE; FATALITY; FATIGUE; HUMAN; KERATOPATHY; LOWER EYELID; MALE; MUCOSA INFLAMMATION; NEUTROPENIA; ODYNOPHAGIA; POLYURIA; PREOPERATIVE TREATMENT; RASH; RECTUM CARCINOMA; SCLERODERMA; THROMBOCYTOPENIA; UPPER EYELID;

AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA; DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY; ECTROPION; FLUOROURACIL; HUMANS; MALE; RECTAL NEOPLASMS;

EID: 79957527347     PISSN: 15569527     EISSN: 15569535     Source Type: Journal    
DOI: 10.3109/15569527.2010.532846     Document Type: Article

References (5)

1. Ichikawa W, Uetake H, Shirota Y, Yamada H, Nishi N, Nihei Z, Sugihara K, Hirayama R. Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clin Cancer Res 2003, 9, 786-791. (Pubitemid 36182616)
2. Heggie GD, Sommadossi JP, Cross DS, Huster WJ, Diasio RB. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 1987, 47, 2203-2206. (Pubitemid 17074634)
3. Van Kuilenburg AB, Stroomer AE, Van Lenthe H, Abeling NG, Van Gennip AH. New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid? Biochem J 2004, 379, 119-124. (Pubitemid 38491366)
4. Mattison LK, Fourie J, Desmond RA, Modak A, Saif MW, Diasio RB. Increased prevalence of dihydropyrimidine dehydrogenase deficiency in African-Americans compared with Caucasians. Clin Cancer Res 2006, 12, 5491-5495. (Pubitemid 44497265)
5. Loganayagam A, Arenas-Hernandez M, Fairbanks L, Ross P, Sanderson JD, Marinaki AM. The contribution of deleterious DPYD gene sequence variants to fluoropyrimidine toxicity in British cancer patients. Cancer Chemother Pharmacol 2010, 65, 403-406.