Obesity is associated with impaired cardiac autonomic modulation in children

International Journal of Pediatric Obesity

Volumn 6, Issue 2, 2011, Pages 128-134

  Rodríguez Colón, Sol M ^a   Bixler, Edward O ^a   Li, Xian ^a   Vgontzas, Alexandros N ^a   Liao, Duanping ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

cardiac autonomic modulation; heart rate variability; Obesity; population based study

Indexed keywords

ARTICLE; AUTONOMIC DYSFUNCTION; AUTONOMIC INNERVATION; BODY HEIGHT; BODY MASS; BODY WEIGHT; CARDIAC AUTONOMIC MODULATION; CHILD; CORRELATION ANALYSIS; FEMALE; HEART INNERVATION; HEART RATE VARIABILITY; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; POPULATION RESEARCH; PRIORITY JOURNAL; RR INTERVAL; WAIST CIRCUMFERENCE;

AUTONOMIC NERVOUS SYSTEM; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; ELECTROCARDIOGRAPHY; FEMALE; HEART; HEART RATE; HUMANS; MALE; OBESITY;

EID: 79957514062     PISSN: 17477166     EISSN: 17477174     Source Type: Journal    
DOI: 10.3109/17477166.2010.490265     Document Type: Article

References (54)

1. Kaplan NM. The deadly quartet: upper-body obesity, glucose intolerance, hypertrygliceridemia, and hypertension. Arch Intern Med. 1989;149:1514-20. (Pubitemid 19177621)
2. Ogden CL, Carroll MD, Flegal KM. High Body Mass Index for Age among US children and adolescents, 2003-2006. JAMA. 2008;299(20):2401-5. (Pubitemid 351749238)
3. Wang Y, Lobstein T. Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes. 2006;1:11-25.
4. Dietz WH. Overweight in childhood and adolescence. N Engl J Med. 2004;350:855-7. (Pubitemid 38252530)
5. Martin GJ, Magid NM, Myers G, et al. Heart rate variability and sudden death secondary to coronary artery disease during ambulatory electrocardiagraphic monitoring. Am J Cardiol. 1987;60:86-9. (Pubitemid 17125657)
6. Tsuji H, Larson MG, Venditti FJ, Jr, et al. Impact of reduced heart rate variability on cardiac events, The Framingham Heart Study. Circulation. 1996;94:2850-5. (Pubitemid 26411751)
7. Liao D, Cai J, Rosamond W, et al. Cardiac autonomic function and incident CHD: A population based case-cohort study - The ARIC Study. Am J Epidemiol. 1997;145: 696-706. (Pubitemid 27175281)
8. Dekker JM, Crow RS, Folsom AR, et al. Low heart rate variability in a two minute rhythm strip predicts risk of coronary heart disease and mortality from several causes-The ARIC Study. Circulation. 2000;102:1239-44.
9. Liao D, Carnethon MR, Evans GW, Cascio WE, Heiss G. Lower Heart Rate Variability is Associated with the Development of Coronary Heart Disease in Individuals with Diabetes - The ARIC Study. Diabetes. 2002;51:3524-31. (Pubitemid 35403460)
10. Liao D, Cai Jianwen, Barnes RW, et al. Association of cardiac autonomic function and the development of hypertension- The ARIC Study. Am J Hypertens.1996;9:1147-56. (Pubitemid 26423637)
11. Pfeifer MA, Cook D, Brodsky J, et al. Quantitative evaluation of cardiac parasympathetic activity in normal and diabetic man. Diabetes. 1982;31:339-45. (Pubitemid 12135298)
12. Bigger JT. Spectral analysis of R-R variability to evaluate autonomic physiology and pharmacology and to predict cardiovascular outcomes in humans. In: Zipes D, Jalife J, editors. Cardiac Electrophysiology: From the Cell to the Bedside. 2nd ed. Philadelphia, PA: WB Saunders Co.;1995. p. 1151-70.
13. Akselrod S, Gordon D, Ubel FA, Shannon DC, Berger AC, Cohen RJ. Power spectrum analysis of heart rate fl uctuation: A quantitative probe of beat-to-beat cardiovascular control. Science. 1981;213:220-2. (Pubitemid 11060568)
14. Pomeranz B, Macaulay RJ, Caudill MA, et al. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol. 1985;248:H151-3. (Pubitemid 15170666)
15. Hayano J, Sakakibara Y, Yamada A, et al. Accuracy of assessment of cardiac parasympathetic tone by heart rate variability in normal subjects. Am J Cardiol. 1991;67:99-104.
16. Pagani M, Lombardi F, Guzzetti S, et al. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho- parasympathetic interaction in man and conscious dog. Circ Res. 1986;59:178-93. (Pubitemid 16017873)
17. Kamath MV, Ghista DN, Fallen EL, Fitchett D, Miller D, McKelvie R. Heart rate variability power spectrogram as a potential noninvasive signature of cardiac regulatory system response, mechanisms, and disorders. Heart Vessels. 1987;3:33-41. (Pubitemid 17118093)
18. Malik M, Camm AJ. Heart rate variability. Clin Cardiol. 1990;13:570-76. (Pubitemid 20256074)
19. Ori Z, Monir G, Weiss J, Sayhouni X, Singer DH. Heart rate variability-Frequency domain analysis. Clin Cardiol. 1992;10:499-537.
20. Kleiger RE, Miller JP, Bigger JT, Jr., Moss AJ. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol. 1987;59:256-62. (Pubitemid 17036947)
21. Vaishnav S, Stevenson R, Marchant B , Lagi K, Ranjadayalan K, Timmis AD. Relation between heart rate variability early after acute myocardial infarction and long-term mortality. Am J Cardiol. 1994;73:653-7. (Pubitemid 24128853)
22. Lombardi F, Sandrone G, Pernpruner S, et al. Heart rate variability as an index of sympathovagal interaction after acute myocardial infarction. Am J Cardiol. 1987;60: 1239-45.
23. Malik M, Farrell T, Camm AJ. Circadian rhythm of heart rate variability after acute myocardial infarction and its infl uence on the prognostic value of heart rate variability. Am J Cardiol. 1990;66:1049-54. (Pubitemid 20365355)
24. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology: Heart Rate Variability: Standards of measurement, physiological interpretation, and clinical use. Circulation. 1996;93:1043-65.
25. Williams EF III, Woo P, Miller R, Kellman RM. The effects of adenotonsillectomy on growth in young children. Otolaryngol Head Neck Surg. 1991;104:509-16.
26. Liao D, Evans GW, Chambless LE, et al. Population based study of heart rate variability and prevalent myocardial infarction: The ARIC Study. J Electrocardiol. 1996;29: 189-98. (Pubitemid 26269728)
27. Liao D, Creason J, Shy C, Williams R, Watts R, Zweidinger R. Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. Environ Health Perspect. 1999;107:521-5. (Pubitemid 29371033)
28. Liao D, Sloan RP, Cascio WE, et al. The multiple metabolic syndrome is associated with lower heart rate variability: The ARIC Study. Diabetes Care. 1998;21:2116-22. (Pubitemid 28549160)
29. Carnethon MR, Liao D, Evans GW, et al. Does the Cardiac Autonomic Response to Postural Change Predict Incident Coronary Heart Disease and Mortality? The Atherosclerosis Risk in Communities Study. Am J Epidemiol. 2002;155:48-56. (Pubitemid 34042432)
30. Carnethon MR, Liao D, Evans GW, Cascio WE, Chambless LE, Heiss G. Correlates of the shift in heart rate variability with an active postural change in a healthy population sample: The Atherosclerosis Risk In Communities study. Am Heart J. 2002;143:808-13. (Pubitemid 34595337)
31. Carnethon MR, Anthony MS, Cascio WE, et al. Prospective Association between Hormone Replacement Therapy and Heart Rate Variability: The Atherosclerosis Risk in Communities Study. J Clin Epid. 2003;56:565-71. (Pubitemid 36842915)
32. Carnethon MR, Golden SH, Folsom AR, Haskell W, Liao D. Prospective investigation of autonomic nervous system function and the development of type 2 diabetes: the Atherosclerosis Risk in Communities study, 1987-1998. Circulation. 2003;107:2190-5. (Pubitemid 36547211)
33. Schroeder EB, Welch VL, Couper D, et al. Lung Function and Incident Coronary Heart Disease - The Atherosclerosis Risk in Communities Study. Am J Epidemiol. 2003;158:1171-81. (Pubitemid 37548787)
34. Schroeder EB, Liao D, Chambless LE, Evans GW, Heiss G. Hypertension, Blood Pressure, and Heart Rate Variability: The Atherosclerosis Risk in Communities (ARIC) Study. Hypertension. 2003;42:1106-11.
35. Liao D, Duan Y, Whitsel EA, et al. Higher Ambient Criteria Pollutants are Associated with Impaired Cardiac Autonomic Control-A Population-based Study. Am J Epid. 2004;159: 768-77. (Pubitemid 38656134)
36. Kaufman CL, Kaiser DR, Steinberger J, Kelly AS, Dengel DR. Relationship of cardiac autonomic function with metabolic abnormalities in childhood obesity. Obesity. 2007;15(5):1164-70.
37. Martini G, Riva P, Rabbia F, et al. Heart rate variability in childhood obesity. Clin Auto Res. 2001;11:87-91. (Pubitemid 33028941)
38. Rabbia F, Silke B, Conterno A, et al. Assessment of cardiac autonomic modulation during adolescent obesity. Obes Res. 2003;11:541-8. (Pubitemid 41202415)
39. Yakinci C, Mungen B, Karabiber H, Tayfun M, Evereklioglu C. Autonomic nervous system functions in obese children. Brain Dev. 2001;22:151-3.
40. Nagai N, Matsumoto T, Kita H, Moritani T. Autonomic nervous system activity and the state and development of obesity in Japanese school children. Obes Res. 2003;11:25-32. (Pubitemid 41137535)
41. Bixler EO, Vgontzas AN, Lin HM, et al. Blood pressure associated with sleep-disordered breathing in a population sample of children. Hypertension. 2008;52(5):841-6.
42. Liao D, Liu J, Vgontzas A, et al. Cardiac Autonomic Modulation and Sleep-Disordered Breathing in Children. Sleep Med Clin. 2009;4:27-36.
43. Cole TJ, Bellizzi MC, Flegal KM, et al. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000;320:1240-3. (Pubitemid 30240471)
44. The Biomedical Signal Analysis Group, Department of Applied Physics, University of Kuopio, Finland. The HRV Analysis Software. (http://bsamig.uku.fi/ research/hrv.shtml) (Accessed November 3, 2009).
45. Peterson HR, Rothschild M, Wienberg CR, Fell RD, McLeish KR, Pfeifer MA. Boby fat and the activity of the autonomic nervous system. N Engl J Med. 1998;318: 1077-83.
46. R ossi M, Marti G, Ricordi L, et al. Cardiac autonomic dysfunction in obese subjects. Clin Sci. 1989;76:567-72. (Pubitemid 19138087)
47. Grassi G, Seravalle G, Cattaneo BM, et al. Sympathetic activation obese normotensive subjects. Hypertension. 1995;25: 560-3.
48. Arone LJ, Mackintosh R, Rosembaum M, Leibel RL, Hirsch J. Autonomic nervous system activity in weight gain and weight loss. Am J Physiol. 1995;169(pt 1):R222-5.
49. Gutin B, Owens S, Slavens G, Riggs S, Treiber F. Effect of physical training on heart-period variability in obese children. J Pediatr. 1997;130:938-43. (Pubitemid 27495122)
50. Gutin B, Barbeau P, Litaker MS, Ferguson M, Owens S. Heart Rate Variability in Obese Children: Relations to Total Body and Visceral Adiposity, and Changes with Physical Training and Detraining. Obes Res. 2000;8:12-9.
51. Akehi Y, Yoshimatsu H, Kurokawa M, et al. VLCD-induced weight loss improves heart rate variability in moderately obese Japanese. Exp Biol Med. 2001;226(5):440-5. (Pubitemid 32506369)
52. Verwaerde P, Sénard JM, Galinier M, et al. Changes in shortterm variability of blood pressure and heart rate during the development of obesity-associated hypertension in high-fat fed dogs. J Hypertens. 1999;17(8):1135-43. (Pubitemid 29389561)
53. Emdin M, Gastaldelli A, Muscelli E, et al. Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight loss. Circulation. 2001;103:513-9. (Pubitemid 32116235)
54. McCaffrey PM, Riddell JG, Shanks RG. An assessment of the partial agonist activity of Ro 31-1118, fl usoxolol and pindolol in man. Br J Clin Pharmacol. 1987;24(5):571-80. (Pubitemid 18078351)