A combination of exosomes carrying TSA derived from HLA-A2-positive human white buffy coat and polyi:C for use as a subcellular antitumor vaccination

Journal of Immunoassay and Immunochemistry

Volumn 32, Issue 3, 2011, Pages 207-218

  Ren, Wei Na ^a   Chang, Chun Kang ^a   Fan, Hua Hua ^b   Guo, Fang ^a   Ren, Ya Na ^b   Yang, Jie ^b   Guo, Juan ^a   Li, Xiao ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Blood Center   (China)

Author keywords

antigen peptide; exosome; HLA A2; human; K562; polyI:C; transgenic mice

Indexed keywords

B7 ANTIGEN; CANCER VACCINE; CD86 ANTIGEN; GLYCOPROTEIN P 15095; HLA A2 ANTIGEN; MEMBRANE ANTIGEN; NY ESO 1 ANTIGEN; POLYINOSINIC POLYCYTIDYLIC ACID; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BUFFY COAT; CANCER IMMUNIZATION; CELL STRAIN K 562; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG DELIVERY SYSTEM; EXOSOME; HUMAN; HUMAN CELL; LIPOSOMAL DELIVERY; LYMPHOCYTE PROLIFERATION; MALE; MELANOMA CELL; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SPLEEN CELL; SUPERNATANT; TRANSGENIC MOUSE;

ADULT; ANIMALS; ANTIGENS, NEOPLASM; BLOOD BUFFY COAT; CANCER VACCINES; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; DENDRITIC CELLS; EXOSOMES; FLOW CYTOMETRY; HLA-A2 ANTIGEN; HUMANS; LEUKOCYTES, MONONUCLEAR; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; POLY I-C; RECOMBINANT PROTEINS;

EID: 79957492621     PISSN: 15321819     EISSN: 15324230     Source Type: Journal    
DOI: 10.1080/15321819.2011.559295     Document Type: Article

References (14)

1. Théry, C.; Boussac, M.; Véron, P.; Ricciardi-Castagnoli, P.; Raposo, G.; Garin, J.; Amigorena, S. Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles. J. Immunol. 2001, 166, 7309-7318. (Pubitemid 32525606)
2. Kim, J.; Sitaraman, S.; Hierro, A.; Beach, B. M.; Odorizzi, G.; Hurley, J. H. Structural Basis for Endosomal Targeting by the Bro1 Domain. Dev. Cell 2005, 8, 937-947. (Pubitemid 40754064)
3. Kadowaki, N.; Ho, S.; Antonenko, S.; Malefyt, R. W.; Kastelein, R. A; Bazan, F.; Liu, Y J. Subsets of Human Dendritic Cell Precursors Express Different Toll-Like Receptors and Respond to Different Microbial Antigens. J. Exp. Med. 2001, 194, 863-861.
4. Chaput, N.; Schartz, N.; André, F.; Tä?eb, J.; Novault, S.; Bonnaventure, P.; Aubert, N.; Bernard, J.; Lemonnier, F; Merad, M.; Adema, G.; Adams, M.; Ferrantini, M.; Carpentier, A. F; Escudier, B.; Tursz, T.; Angevin, E.; Zitvogel, L. Exosomes as Potent Cell-Free Peptide-Based Vaccine: II. Exosomes in CpG Adjuvants Efficiently Prime Naive Tc1 Lymphocytes Leading to Tumor Rejection. J. Immunol. 2004, 172, 2137-2146. (Pubitemid 38182359)
5. Nicholaou, T.; Ebert, L.; Dabis, I. D.; Robson, N.; Klein, O.; Maraskovsky, E.; Chen, W.; Cebon, J. Directions in the Immune Targeting of Cancer: Lessons Learned from the Cancer-Testis Ag NY-ESO-1. Immunol. CellBiol. 2006, 84, 303-317.
6. Hao, S.; Moyana, T; Xiang, J. Cancer Immunotherapy by Exosome-Based Vaccines. Cancer Biother. Radiopharm. 2007, 22(5), 693-703.
7. Guo, F; Chang, C K.; Fan, H. H.; Nie, X. X.; Ren, Y N.; Liu, Y Y; Zhao, L. H. Anti-Tumor Effects of Exosomes in Combination with Cyclophosphamide and Polyinosinic-Polycytidelic Acid. J. Int. Med. Res. 2008, 36(6), 1342-1353.
8. Conrad, C.; Nestle, F. O. Dendritic Cell-Based Cancer Therapy. Curr. Opin. Mol. Ther. 2003, 5, 405-412. (Pubitemid 37080900)
9. Cho, J.-A.; Lee, Y.-S.; Kim, S.-H.; Ko, J. K.; Kim, C W. MHC Independent Anti-Tumor Immune Responses Induced by Hsp70-Enriched Exosomes Generate Tumor Regression in Murine Models. Cancer Lett. 2009, 257, 256-265
10. Temchura, V. V.; Tenbusch, M.; Nchindal, G.; Nabi, G.; Tippler, B.; Zelenyuk, M.; Wildner, O.; Uberla, K.; Kuate, S. Enhancement of Immunostimulatory Properties of Exosomal Vaccines by Incorporation of Fusion-Competent G Protein of Vesicular Stomatitis Virus. Vaccine 2008, 26, 3662-3672.
11. Yang, Y; Xiu, F.; Cai, Z.; Wang, J.; Wang, Q.; Fu, Y; Cao, X. Increased Induction of Antitumor Response by Exosomes Derived from Interleukin-2 Gene-Modi Wed Tumor Cells.J. Cancer. Res. Clin. Oncol. 2007, 133, 389-399. (Pubitemid 46716703)
12. André, F; Chaput, N.; Schartz, N. E.; Flament, C.; Aubert, N.; Bernard,J.; Lemonnier, F.; Raposo, G.; Escudier, B.; Hsu, D. H.; Tursz, T; Amigorena, S.; Angevin, E.; Zitvogel, L. Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells. J. Immunol. 2004, 172(4), 2126-2136.
13. Sutmuller, R.; Garritsen, A.; Adema, G. J.; Regulatory T Cells and Toll-Like Receptors: Regulating the Regulators. Ann. Rheum. Dis. 2007, 66(Suppl. 3), 91-95.
14. Escudier, B.; Dorval, T; Chaput, N.; André, F.; Caby, M. P; Novault, S.; Flament, C.; Leboulaire, C.; Borg, C.; Amigorena, S.; Boccaccio, C.; Bonnerot, C.; Dhellin, O.; Movassagh, M.; Piperno, S.; Robert, C.; Serra, V.; Valente, N.; Le Pecq, J. B.; Spatz, A.; Lantz, O.; Tursz, T; Angevin, E.; Zitvogel, L. Vaccination of Metastatic Melanoma Patients with Autologous Dendritic Cell (DCs) Derived Exosomes: Results of the First Phase I Clinical Trial. J. Transl. Med. 2005, 3, 10.