Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: A randomized trial

JAMA

Volumn 305, Issue 20, 2011, Pages 2071-2079

  Rauch, Steven D ^a   Halpin, Christopher F ^a,b   Antonelli, Patrick J ^c   Babu, Seilesh ^d   Carey, John P ^e   Gantz, Bruce J ^f   Goebel, Joel A ^g   Hammerschlag, Paul E ^h   Harris, Jeffrey P ⁱ   Isaacson, Brandon ^j   Lee, Daniel ^a   Linstrom, Christopher J ^k   Parnes, Lorne S ^l   Shi, Helen ^m   Slattery, William H ⁿ   Telian, Steven A ^o   Vrabec, Jeffrey T ^p   Reda, Domenic J ^m  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d MICHIGAN EAR INSTITUTE   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f UNIVERSITY OF IOWA   (United States)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h NEW YORK UNIVERSITY   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^k NEW YORK EYE AND EAR INFIRMARY   (United States)

^l UNIVERSITY OF WESTERN ONTARIO   (Canada)

^m HINES VA HOSPITAL   (United States)

ⁿ HOUSE EAR INSTITUTE   (United States)

^o UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^p BAYLOR COLLEGE OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPREDNISOLONE; PHENOL; PREDNISONE; STEROID;

ADULT; AGE; AGED; APPETITE; ARTICLE; AUDITORY THRESHOLD; BLADDER CANCER; BLOOD CELL COUNT; BRAIN HEMORRHAGE; BRIEF CALORIC VERTIGO; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DIZZINESS; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG USE; DRUG WITHDRAWAL; EAR INFECTION; EARDRUM PERFORATION; FEMALE; GLUCOSE BLOOD LEVEL; HEARING; HEART INFARCTION; HOSPITALIZATION; HUMAN; HYPONATREMIA; IDIOPATHIC DISEASE; IDIOPATHIC SUDDEN SENSORINEURAL HEARING LOSS; INJECTION SITE PAIN; INTENTION TO TREAT ANALYSIS; LEUKEMIA; MAJOR CLINICAL STUDY; MALE; MIDDLE EAR; MOOD CHANGE; MULTICENTER STUDY; OSTEOMYELITIS; OTALGIA; OTITIS MEDIA; PERCEPTION DEAFNESS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PURE TONE AUDIOMETRY; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SLEEP; SYNCOPE; THIRST; THORAX PAIN; TOE OSTEOMYELITIS; TREATMENT DURATION; TREATMENT OUTCOME; VERTIGO; WEIGHT CHANGE; WORD RECOGNITION; XEROSTOMIA;

EID: 79957486477     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2011.679     Document Type: Article

References (37)

1. Byl FM Jr. Sudden hearing loss: eight years' experience and suggested prognostic table. Laryngoscope. 1984;94(5 pt 1):647-661.
2. Simmons FB. Sudden idiopathic sensori-neural hearing loss: some observations. Laryngoscope. 1973; 83(8):1221-1227.
3. Shaia FT, Sheehy JL. Sudden sensori-neural hearing impairment: a report of 1,220 cases. Laryngoscope. 1976;86(3):389-398.
4. Mattox DE, Simmons FB. Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol. 1977;86(4 pt 1):463-480. (Pubitemid 8161819)
5. Fetterman BL, Saunders JE, Luxford WM. Prognosis and treatment of sudden sensorineural hearing loss. Am J Otol. 1996;17(4):529-536. (Pubitemid 26254906)
6. Megighian D, Bolzan M, Barion U, Nicolai P. Epidemiological considerations in sudden hearing loss: a study of 183 cases. Arch Otorhinolaryngol. 1986;243(4):250-253. (Pubitemid 16008868)
7. Alexiou C, Arnold W, Fauser C, et al. Sudden sensorineural hearing loss: does application of glucocorticoids make sense? Arch Otolaryngol Head Neck Surg. 2001;127(3):253-258.
8. Kallinen J, Laurikainen E, Laippala P, Grénman R. Sudden deafness: a comparison of anticoagulant therapy and carbogen inhalation therapy. Ann Otol Rhinol Laryngol. 1997;106(1):22-26. (Pubitemid 27058136)
9. Nakashima T, Itoh A, Misawa H, Ohno Y. Clinicoepidemiologic features of sudden deafness diagnosed and treated at university hospitals in Japan. Otolaryngol Head Neck Surg. 2000;123(5):593-597.
10. Yanagita N, Nakashima T, Ohno Y, Kanzaki J, Shitara T. Estimated annual number of patients treated for sensorineural hearing loss in Japan: results of a nationwide epidemiological survey in 1987. Acta Otolaryngol Suppl. 1994;514:9-13.
11. Minoda R, Masuyama K, Habu K, Yumoto E. Initial steroid hormone dose in the treatment of idiopathic sudden deafness. Am J Otol. 2000;21(6):819-825.
12. Wilson WR, Byl FM, Laird N. The efficacy of steroids in the treatment of idiopathic sudden hearing loss: a double-blind clinical study. Arch Otolaryngol. 1980;106(12):772-776. (Pubitemid 11194190)
13. Chen CY, Halpin C, Rauch SD.Oral steroid treatment of sudden sensorineural hearing loss: a ten year retrospective analysis. Otol Neurotol. 2003;24(5):728-733. (Pubitemid 37122536)
14. Parnes LS, Sun AH, Freeman DJ. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope. 1999;109(7 pt 2):1-17.
15. Chandrasekhar SS. Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation. Otol Neurotol. 2001;22(1):18-23. (Pubitemid 32182848)
16. Banerjee A, Parnes LS. Intratympanic corticosteroids for sudden idiopathic sensorineural hearing loss. Otol Neurotol. 2005;26(5):878-881. (Pubitemid 41330701)
17. Fitzgerald DC, McGuire JF. Intratympanic steroids for idiopathic sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol. 2007;116(4):253-256. (Pubitemid 46651179)
18. Darmstadt GL, Harris JP. Luetic hearing loss: clinical presentation, diagnosis, and treatment. Am J Otolaryngol. 1989;10(6):410-421. (Pubitemid 20002199)
19. Chia EM, Wang JJ, Rochtchina E, Cumming RR, Newall P, Mitchell P. Hearing impairment and health-related quality of life: the Blue Mountains Hearing Study. Ear Hear. 2007;28(2):187-195. (Pubitemid 46673496)
20. Jerger J, Chmiel R. Factor analytic structure of auditory impairment in elderly persons. J Am Acad Audiol. 1997;8(4):269-276.
21. Gates GA, Cooper JC Jr, Kannel WB, Miller NJ. Hearing in the elderly: the Framingham cohort, 1983-1985, I: basic audiometric test results. Ear Hear. 1990;11(4):247-256.
22. S3. 21: American National Standard Methods for Manual Pure Tone Audiometry. New York, NY: American National Standards Institute; 2004. .
23. Dirks D. Factors related to bone conduction reliability. Arch Otolaryngol. 1964;79:551-558.
24. Alexander TH, Weisman MH, Derebery JM, et al. Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. Otol Neurotol. 2009;30(4):443-448.
25. Plontke SK, Salt AN. Quantitative interpretation of corticosteroid pharmacokinetics in inner fluids using computer simulations. Hear Res. 2003;182(1-2):34-42. (Pubitemid 37013281)
26. Plontke SK, Biegner T, Kammerer B, Delabar U, Salt AN. Dexamethasone concentration gradients along scala tympani after application to the round window membrane. Otol Neurotol. 2008;29(3):401-406. (Pubitemid 351450804)
27. Plontke SK, Mikulec AA, Salt AN. Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph [Otol Neurotol. 2007;28:1124-30]. Otol Neurotol. 2008;29(5):732-733.
28. Battaglia A, Burchette R, Cueva R. Combination therapy (intratympanic dexamethasone + high-dose prednisone taper) for the treatment of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2008;29(4):453-460.
29. Stokroos RJ, Albers FW, Tenvergert EM. Antiviral treatment of idiopathic sudden sensorineural hearing loss: a prospective, randomized, double-blind clinical trial. Acta Otolaryngol. 1998;118(4):488-495. (Pubitemid 28351326)
30. Tucci DL, Farmer JC Jr, Kitch RD, Witsell DL. Treatment of sudden sensorineural hearing loss with systemic steroids and valacyclovir. Otol Neurotol. 2002;23(3):301-308. (Pubitemid 34506637)
31. Westerlaken BO, Stokroos RJ, Dhooge IJ, Wit HP, Albers FW. Treatment of idiopathic sudden sensorineural hearing loss with antiviral therapy: a prospective, randomized, double-blind clinical trial. Ann Otol Rhinol Laryngol. 2003;112(11):993-1000. (Pubitemid 37429645)
32. Ho HG, Lin HC, Shu MT, Yang CC, Tsai HT. Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment. Laryngoscope. 2004;114(7):1184-1189.
33. Herr BD, Marzo SJ. Intratympanic steroid perfusion for refractory sudden sensorineural hearing loss. Otolaryngol Head Neck Surg. 2005;132(4):527-531. (Pubitemid 40460877)
34. Choung YH, Park K, Shin YR, Cho MJ. Intratympanic dexamethasone injection for refractory sudden sensorineural hearing loss. Laryngoscope. 2006;116(5):747-752. (Pubitemid 44318031)
35. Haynes DS, O'Malley M, Cohen S, Watford K, Labadie RF. Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy. Laryngoscope. 2007;117(1):3-15. (Pubitemid 46066055)
36. She W, Dai Y, Du X, et al. Hearing evaluation of intratympanic methylprednisolone perfusion for refractory sudden sensorineural hearing loss. Otolaryngol Head Neck Surg. 2010;142(2):266-271.
37. Dallan I, De Vito A, Fattori B, et al. Intratympanic methylprednisolone in refractory sudden hearing loss: a 27-patient case series with univariate and multivariate analysis. Otol Neurotol. 2010;31(1):25-30.