Preservation of peripheral vasodilation as a surrogate of cardioprotection? the mechanistic role of ATP-dependent potassium channels and the mitochondrial permeability transition pore

European Heart Journal

Volumn 32, Issue 10, 2011, Pages 1184-1186

  Heusch, Gerd ^a   Schulz, Rainer ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CYCLOSPORIN A; GLIBENCLAMIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE;

ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; ATHEROSCLEROTIC PLAQUE; CORONARY ARTERY DISEASE; CORONARY RISK; ENDOTHELIUM CELL; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART ISCHEMIC POSTCONDITIONING; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; INFLAMMATION; INFLAMMATORY CELL; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; SMOOTH MUSCLE FIBER; VASODILATATION;

BRACHIAL ARTERY; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; ISCHEMIC POSTCONDITIONING; KATP CHANNELS; MALE; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; REPERFUSION INJURY;

EID: 79957470352     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehq511     Document Type: Review

References (15)

1. Diehm C, Allenberg JR, Pittrow D, Mahn M, Tepohl G, Haberl RL, Darius H, Burghaus I, Trampisch HJ. Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease. Circulation 2009;120: 2053-2061.
2. Böhm M, Baumhakel M, Teo K, Sleight P, Probstfield J, Gao P, Mann JF, Diaz R, Dagenais GR, Jennings GL, Liu L, Jansky P, Yusuf S. Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (ONTARGET/TRANSCEND) Trials. Circulation 2010;121:1439-1446.
3. Okorie MI, Bhavsar DD, Ridout D, Charakida M, Deanfield JE, Loukogeorgakis SP, MacAllister RJ. Postconditioning protects against human endothelial ischaemia- reperfusion injury via subtype-specific KATP channel activation and is mimicked by inhibition of the mitochondrial permeability transition pore. Eur Heart J 2011;32:1266-1274. First published on 28 February 2011. doi:10.1093/ eurheartj/ehr041.
4. Ovize M, Baxter GF, Di Lisa F, Ferdinandy P, Garcia-Dorado D, Hausenloy DJ, Heusch G, Vinten-Johansen J, Yellon DM, Schulz R. Postconditioning and protection from reperfusion injury: Where do we stand? Cardiovasc Res 2010;87: 406-423.
5. Heusch G, Boengler K, Schulz R. Cardioprotection: Nitric oxide, protein kinases, and mitochondria. Circulation 2008;118:1915-1919.
6. Heusch G, Boengler K, Schulz R. Inhibition of mitochondrial permeability transition pore opening: The holy grail of cardioprotection. Basic Res Cardiol 2010; 105:151-154.
7. Zeiher AM, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest 1993;92:652-662. (Pubitemid 23262382)
8. Charakida M, Masi S, Luscher TF, Kastelein JJ, Deanfield JE. Assessment of atherosclerosis: The role of flow-mediated dilatation. Eur Heart J 2010;31:2854-2861.
9. O'Rourke B. Evidence for mitochondrial K+ channels and their role in cardioprotection. Circ Res 2004;94:420-432. (Pubitemid 38326277)
10. Flagg TP, Enkvetchakul D, Koster JC, Nichols CG. Muscle KATP channels: Recent insights to energy sensing and myoprotection. Physiol Rev 2010;90:799-829.
11. Gutterman DD, Miura H, Liu Y. Redox modulation of vascular tone: Focus of potassium channel mechanisms of dilation. Arterioscler Thromb Vasc Biol 2005;25:671-678. (Pubitemid 40463852)
12. Grossini E, Molinari C, Caimmi PP, Uberti F, Vacca G. Levosimendan induces NO production through pp38 MAPK, ERK and Akt in porcine coronary endothelial cells: Role for mitochondrial K(ATP) channel. Br J Pharmacol 2009;156:250-261.
13. Rottlaender D, Boengler K, Wolny M, Michels G, Endres-Becker J, Motloch LJ, Schwaiger A, Buechert A, Schulz R, Heusch G, Hoppe UC. Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes. J Clin Invest 2010;120:1441-1453.
14. Lo Russo A, Passaquin A-C, Skutella AM, Rüegg UT. Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: Possible lack of relationship to immunosuppressive activity. Br J Pharmacol 1996;118:885-892. (Pubitemid 26261258)
15. Bouvier N, Flinois JP, Gilleron J, Sauvage FL, Legendre C, Beaune P, Thervet E, Anglicheau D, Pallet N. Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: A role for endothelial phenotypic changes and death. Am J Physiol Renal Physiol 2009;296:F160-F169.