Evaluation of physical and chemical changes in pharmaceuticals flown on space missions

AAPS Journal

Volumn 13, Issue 2, 2011, Pages 299-308

  Du, Brian ^a   Daniels, Vernie R ^a   Vaksman, Zalman ^b   Boyd, Jason L ^c   Crady, Camille ^a   Putcha, Lakshmi ^d  

^a WYLE LABORATORIES   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

^d NASA JOHNSON SPACE CENTER   (United States)

Author keywords

chromatography; dissolution; pharmaceutical stability; potency; space radiation

Indexed keywords

ACICLOVIR; ADRENALIN; AMOXICILLIN PLUS CLAVULANIC ACID; ATORVASTATIN; AZITHROMYCIN; CEFADROXIL; CILASTATIN PLUS IMIPENEM; CIPROFLOXACIN; CLOTRIMAZOLE; COBALAMIN; COTRIMOXAZOLE; DEXAMPHETAMINE; FLUCONAZOLE; FUROSEMIDE; IBUPROFEN; LEVOFLOXACIN; LEVOTHYROXINE; LIDOCAINE; METOPROLOL SUCCINATE; METRONIDAZOLE; PHENYTOIN; PROMETHAZINE; RISEDRONIC ACID; SERTRALINE; SULFADIAZINE SILVER; SULFAMETHOXAZOLE; TEMAZEPAM; TRIAMCINOLONE; TRIMETHOPRIM; UNINDEXED DRUG;

AEROSPACE MEDICINE; ARTICLE; ASTRONOMY; CHEMICAL COMPOSITION; COMPARATIVE STUDY; CONTROLLED STUDY; COSMIC RADIATION; DRUG DEGRADATION; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; ENVIRONMENTAL FACTOR; EXPIRATION DATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMIDITY; IONIZING RADIATION; PHYSICAL CHEMISTRY; PROFESSIONAL STANDARD; QUALITY CONTROL; RADIATION DOSE; RADIATION EXPOSURE; SHELF LIFE; SPACE FLIGHT; TEMPERATURE SENSITIVITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUG STORAGE; HUMIDITY; PHARMACEUTICAL PREPARATIONS; RADIATION DOSAGE; RADIATION, IONIZING; SOLUBILITY; SPACE FLIGHT; SPACECRAFT; TEMPERATURE; TIME FACTORS;

EID: 79957469966     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9270-0     Document Type: Article

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