The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia

European Journal of Dermatology

Volumn 21, Issue 1, 2011, Pages 79-82

  Mumcuoglu, Ceyda ^a   Ekmekci, Tugba Rezan ^a   Ucak, Sema ^b  

^a HAYDARPASA NUMUNE EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^b SISLI ETFAL TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Androgenetic alopecia; Hypercholesterolemia; Hypertension; Insulin resistance; Men; Metabolic syndrome

Indexed keywords

CHOLESTEROL; GLUCOSE; INSULIN; LIPID; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MALE TYPE ALOPECIA; METABOLIC SYNDROME X; ORAL GLUCOSE TOLERANCE TEST; RISK REDUCTION; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; ADOLESCENT; ALOPECIA; COMORBIDITY; HYPERCHOLESTEROLEMIA; LIFESTYLE; ONSET AGE; PATHOPHYSIOLOGY;

ADOLESCENT; ADULT; AGE OF ONSET; ALOPECIA; COMORBIDITY; HUMANS; HYPERCHOLESTEROLEMIA; LIFE STYLE; MALE; METABOLIC SYNDROME X; YOUNG ADULT;

EID: 79957468947     PISSN: 11671122     EISSN: 19524013     Source Type: Journal    
DOI: 10.1684/ejd.2010.1193     Document Type: Article

References (34)

1. Lotufo PA, Chae CU, Ajani UA, Hennekens CH, Manson JE. Male pattern baldness and coronary heart disease: the Physicians' Health Study. Arch Intern Med 2000; 160: 165-71.
2. Ford ES, Freedman DS, Byers T. Baldness and ischemic heart disease in a national sample of men. Am J Epidemiol 1996; 143: 651-7.
3. Schnohr P, Lange P, Nyboe J, Appleyard M, Jensen G. Gray hair, baldness, and wrinkles in relation to myocardial infarction: the Copenhagen City Heart Study. Am Heart J 1995; 130: 1003-10.
4. Halim MM, Meyrick G, Jeans WD, Murphy D, Burton JL. Myocardial infarction, androgen and the skin. Br J Dermatol 1978; 98: 63-8.
5. Cooke NT. Male pattern alopecia and coronary artery disease in men. Br J Dermatol 1979; 101: 455-8.
6. Ellis JA, Stebbing M, Harrap SB. Male pattern baldness is not associated with established cardiovascular risk factors in the general population. Clin Sci (Lond) 2001; 100: 401-4.
7. Gonzalez-Gonzalez JG, Mancillas-Adame LG, Fernández-Reyes M, et al. Androgenetic alopecia and insulin resistance in young men. Clin Endocrinol (Oxf) 2009; 71: 494-9.
8. Matilainen V, Koskela P, Keinanen-Kiukaanniemi S. Early androgenetic alopecia as a marker of insulin resistance. Lancet 2000; 356: 1165-6.
9. Norwood OT. Male pattern baldness: classification and incidence. South Med J 1975; 68: 1359-65.
10. Ludvik B, Nolan JJ, Baloga J, Sacks D, Olefsky J. Effect of obesity on insulin resistance in normal subjects and patients with NIDDM. Diabetes 1995; 44: 1121-5.
11. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-9.
12. Drivsholm T, Hansen T, Urhammer SA. Assessment of insulin sensitivity and beta-cell function from an oral glucose tolerance test. Diabetologia 1999; 42: 185.
13. Raynaud E, Perez-Martin A, Brun JF, Benhaddad AA, Mercier J. Revised concept for the estimation of insulin sensitivity from a single sample. Diabetes Care 1999; 22: 1003-4.
14. Belfiore F, Iannello S, Volpicelli G. Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels. Mol Genet Metab 1998; 63: 134-41.
15. Duncan MH, Singh BM, Wise PH, Carter G, Alaghband-Zadeh J. A simple measure of insulin resistance. Lancet 1995; 346: 120-1.
16. Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402-10.
17. Legro RS, Finegood D, Dunaif A. A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1998; 83: 2694-8.
18. Marques-Vidal P, Mazoyer E, Bongard V, et al. Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers. Diabetes Care 2002; 25: 1371-7.
19. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
20. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-a new worldwide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006; 23: 469-80.
21. Hibberts NA, Howell AE, Randall VA. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp. J Endocrinol 1998; 156: 59-65.
22. Demark-Wahnefried W, Lesko SM, Conaway MR, et al. Serum androgens: associations with prostate cancer risk and hair patterning. J Androl 1997; 18: 495-500.
23. Sheridan PJ, McGill Jr. HC, Aufdemorte TB, Triplett RG, Holt RG. Heart contains receptors for dihydrotestosterone but not testosterone: possible role in the sex differential in coronary heart disease. Anat Rec 1989; 223: 414-9.
24. Ahouansou S, Le Toumelin P, Crickx B, Descamps V. Association of androgenetic alopecia and hypertension. Eur J Dermatol 2007; 17: 220-2.
25. Fujimoto R, Morimoto I, Morita E, Sugimoto H, Ito Y, Eto S. Androgen receptors, 5 alpha-reductase activity and androgen-dependent proliferation of vascular smooth muscle cells. J Steroid Biochem Mol Biol 1994; 50: 169-74.
26. Glazer G. Atherogenic effects of anabolic steroids on serum lipid levels. A literature review. Arch Intern Med 1991; 151: 1925-33.
27. Starka L, Cermakova I, Duskova M, Hill M, Dolezal M, Polacek V. Hormonal profile of men with premature balding. Exp Clin Endocrinol Diabetes 2004; 112: 24-8.
28. Arias-Santiago S, Gutiérrez-Salmerón MT, Castellote-Caballero L, Buendía-Eisman A, Naranjo-Sintes R. Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study. J Am Acad Dermatol 2010; 63: 420-9.
29. Hirsso P, Rajala U, Hiltunen L, et al. Association of low-insulin sensitivity measured by quantitative insulin sensitivity check index with hair loss in 55-year-old men. A Finnish population-based study. Diabetes Obes Metab 2006; 8: 466-8.
30. Ekmekci TR, Ucak S, Basat O, Koslu A, Altuntas Y. The presence of insulin resistance and comparison of various insulin sensivity indices in women with androgenetic alopecia. Eur J Dermatol 2007; 17: 21-5.
31. Matilainen V, Laakso M, Hirsso P, Koskela P, Rajala U, Keinanen-Kiukaanniemi S. Hair loss, insulin resistance, and heredity in middle-aged women. A population-based study. J Cardiovasc Risk 2003; 10: 227-31.
32. Hirsso P, Rajala U, Laakso M, Hiltunen L, Harkonen P, Keinanen-Kiukaanniemi S. Health-related quality of life and physical well-being among a 63-year-old cohort of women with androgenetic alopecia; a Finnish population-based study. Health Qual Life Outcomes 2005; 3: 49.
33. Nabaie L, Kavand S, Robati RM, Sarrafi-Rad N, Shahgholi L, Meshkat-Razavi G. Androgenic alopecia and insulin resistance: are they really related?. Clin Exp Dermatol 2009; 34: 694-7.
34. Reaven GM. Insulin resistance: the link between obesity and cardiovascular disease. Endocrinol Metab Clin North Am 2008; 37: 581-601.