Hair loss, insulin resistance, and heredity in middle-aged women. A population-based study

European Journal of Preventive Cardiology

Volumn 10, Issue 3, 2003, Pages 227-231

  Matilainen, Veikko ^a,c   Laakso, Mauri ^a,b   Hirsso, Päivi ^a   Koskela, Pentti ^d   Rajala, Ulla ^a   Keinänen Kiukaanniemi, Sirkka ^a,b  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

^c Pyhäsalmi Health Centre   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

excessive hair loss; female type of androgenic alopecia; insulin resistance

Indexed keywords

ALBUMIN; CREATININE; INSULIN;

ADULT; ALOPECIA; ANDROGENIC ALOPECIA; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; CREATININE URINE LEVEL; DISEASE ASSOCIATION; FAMILY HISTORY; FEMALE; HAIR LOSS; HEREDITY; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MICROALBUMINURIA; OBESITY; POPULATION RESEARCH; PRIORITY JOURNAL; SMOKING; URINE LEVEL; ANTHROPOMETRY; BLOOD SAMPLING; CLINICAL EXAMINATION; CORONARY ARTERY DISEASE; HIP; HYPERCHOLESTEROLEMIA; LABORATORY TEST; NECK; NURSE; PREVALENCE; QUESTIONNAIRE;

ALOPECIA; BODY MASS INDEX; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; FINLAND; GENETIC PREDISPOSITION TO DISEASE; HEREDITY; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; PREVALENCE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

EID: 0038010316     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1097/01.hjr.0000070200.72977.c6     Document Type: Article

References (20)

1. Dunaif A, Hoffman AR, Scully RE, Flier JS, Longcope C, Levy LJ, et al. Clinical, biochemical, and ovarian morphologic features in women with acanthosis nicrans and masculinization. Obstet Gynecol 1985; 66: 545–552.
2. Carey AH, Chan KL, Short F, White D, Williamson R, Franks S. Evidence for single gene effect causing polycystic ovaries and male pattern baldness. Clin Endocrinol 1993; 38: 653–658.
3. Matilainen V, Koskela P, Keinänen-Kiukaanniemi S. Early androgenic alopecia as a marker of insulin resistance. Lancet 2000; 356: 1165–1166.
4. Kissebah AH, Peiris AN. Biology of regional body fat distribution: Relationship to non-insulin-dependent diabetes mellitus. Diabetes Metab Rev 1989; 5: 83–109.
5. Levine JA, Ray A, Jensen MD. Relation between chubby cheeks and visceral fat. N Engl J Med 1998; 339: 1946–1947.
6. Paik JH, Voon JB, Sim WY, Kim BS, Kim NI. The prevalence and types of androgenic alopecia in Korean men and women. Br J Dermatol 2001; 145: 95–100.
7. Birch MP, Lalla SC, Messenger AG. Female pattern hair loss. Clin Exp Dermatol 2002; 27: 383–388.
8. Rajala U, Keinänen-Kiukaanniemi S, Uusimäki A, et al. Prevalence of diabetes mellitus and impaired glucose tolerance in a middle-aged Finnish population. Scand J Prim Health Care 1995; 13: 222–228.
9. Ludwig E. Classification of the androgenic alopecia (common baldness) arising in the female sex. Br J Dermatol 1977; 97: 249–256.
10. Laakso M, Matilainen V, Keinänen-Kiukaanniemi S. Association of neck circumference with insulin resistance-related factors. Int J Obes 2002; 26: 873–875.
11. Freedman DS, Rimm AA. The relation of body fat distribution, as assessed by six girth measurements, to diabetes mellitus in women. Am J Public Health 1989; 76: 715–720.
12. Yip J, Mattock MB, Morocutti A, Trevisan R, Viberti GC. Insulin resistance in insulin-dependent diabetic patients with microalbuminuria. Lancet 1993; 342: 883–887.
13. Bergfeld WF. Androgenic alopecia: An autosomal dominant disorder. Am J Med 1995; 98: 95–98.
14. Saway ME, Penneys NS. Immunohistochemical distribution of aromatase and 3β-hydroxysteroid dehydrogenase in human hair follicles and sebacous glands. J Cutan Pathol 1991; 19: 309–314.
15. Sheridan PJ, McGill HC, Aufdemorte TB, Triplett RG, Holt RG. Heart contains receptors for dihydrosterone but not testosterone: Possible role in the sex differential in coronary heart disease. Anat Rec 1989; 223: 414–419.
16. Fujimoto R, Morimoto I, Morita E, Sugimoto H, Ito Y, Eto S. Androgen receptors, 5-alpha reductase activity and androgen-dependent proliferation of vascular smooth muscle cells. J Steroid Biochem Mol Biol 1994; 50: 169–174.
17. Pinkney JH, Stehouwer CDA, Coppack SW, Yudkin JS. Endothelial dysfunction: Cause of insulin resistance syndrome. Diabetes 1997; 46: 9–13.
18. Redmont GP, Bergfeld WF. Diagnostic approach to androgen disorder in women: Acne, hirsutism, and alopecia. Clev Clin J Med 1990; 57: 423–427.
19. Ebeling P, Koivisto V. Physiological importance of dehydroepiandrosterone. Lancet 1994; 343: 1479–1481.
20. Tosti A, Misciali C, Piraccini BM, Peluso AM, Bardazzi F. Drug-induced hair loss and hair growth incidence, management and avoidance. Drug Safety 1994; 10: 310–317.