Development of monoclonal antibodies to highly pathogenic avian influenza H5N1 virus and their application to diagnostics, prophylaxis, and therapy

Acta Virologica

Volumn 55, Issue 1, 2011, Pages 3-14

  Masalova, O V ^a   Klimova, R R ^a   Chichev, E V ^a   Fediakina, I T ^a   Loginova, S Ya ^b   Borisevich, S V ^b   Bondarev, V P ^b   Deryabin, P G ^a   Lvov, D K ^a   Kushch, A A ^a  

^a D I IVANOVSKY INSTITUTE OF VIROLOGY   (Russian Federation)

^b Ministry of Defense of the Russian Federation   (Russian Federation)

Author keywords

Hemagglutinin; Highly pathogenic avian influenza virus H5N1; Monoclonal antibodies; Nucleoprotein; Prevention; Rapid diagnostic tests; Treatment

Indexed keywords

MONOCLONAL ANTIBODY; OSELTAMIVIR; RIMANTADINE; EPITOPE; INFLUENZA VIRUS HEMAGGLUTININ; VIRUS ANTIBODY; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGENIC VARIATION; ARTICLE; AVIAN INFLUENZA; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMAGGLUTINATION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; INFLUENZA VIRUS A H5N1; MOUSE; NONHUMAN; PROPHYLAXIS; SERODIAGNOSIS; SINGLE DRUG DOSE; SWINE INFLUENZA VIRUS; VIRUS IDENTIFICATION; ANIMAL; ANTIBIOTIC PROPHYLAXIS; BAGG ALBINO MOUSE; BIRD; CHEMISTRY; CHICK EMBRYO; HEMAGGLUTINATION INHIBITION TEST; IMMUNOLOGY; INFLUENZA VIRUS A; METHODOLOGY; ORTHOMYXOVIRUS INFECTION; SWINE; VIROLOGY;

AVES; AVIAN INFLUENZA VIRUS; INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE; SUIDAE; SWINE INFLUENZA VIRUS;

ANIMALS; ANTIBIOTIC PROPHYLAXIS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; BIRDS; CHICK EMBRYO; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HEMAGGLUTINATION INHIBITION TESTS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; IMMUNOBLOTTING; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; SWINE;

EID: 79957462162     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: 10.4149/av_2011_01_3     Document Type: Article

References (36)

1. Chen H, Smith G, Li K, Wang J, Fan X, Rayner J, Vijaykrishna D, Zhang J, Zhang L, Guo C, Cheung C, Xu K, Duan L, Huang K, Qin K, Leung Y, Wu W, Lu H, Chen Y, Xia N, Naipospos T, Yuen K, Hassan S, Bahri S, Nguyen T, Webster R, Peiris J, Guan Y (2006): Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control. Proc. Natl. Acad. Sci. USA 103, 2845-2850.
2. Chen Y, Qin K, Wu WL, Li G, Zhang J, Du H, Ng MH, Shih JW, Peiris JS, Guan Y, Chen H, Xia N (2009): Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes. J. Infect. Dis. 199, 49-58.
3. Chomel JJ, Thouvenot D, Onno M, Kaiser C, Gourreau JM, Aymard M (1989): Rapid diagnosis of influenza infection of NP antigen using an immunocapture ELISA test. J. Virol. Methods 25, 81-91.
4. Claas E, Osterhaus A, van Beek R, De Jong J, Rimmelzwaan G, Senne D, Krauss S, Shortridge K, Webster R (1998): Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 351, 472-477.
5. Du A, Daidoji T, Koma T, Ibrahim M, Nakamura S, de Silva U, Ueda M, Yang C, Yasunaga T, Ikuta K, Nakaya T (2009): Detection of circulating Asian H5N1 viruses by a newly established monoclonal antibody. Biochem. Biophys. Res. Commun. 378, 197-202.
6. Hanson B, Boon A, Lim A, Webb A, Ooi E, Webby R (2006): Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice. Respir. Res. 7, 0928-0936.
7. He Q, Velumani S, Du Q, Wee Lim C, Kheong Ng F, Donis R, Kwang J (2007): Detection of H5 avian influenza viruses by antigen-capture enzyme-linked immunosorbent assay using H5-specific monoclonal antibody. Clin. Vaccine Immunol. 14, 617-623.
8. Ho H, Qian H, He F, Meng T, Szyporta M, Prabhu N, Prabakaran M, Chan K, Kwang J (2009): Rapid detection of H5N1 subtype influenza viruses by antigen capture enzyme-linked immunosorbent assay using H5-and N1-specific monoclonal antibodies. Clin. Vaccine Immunol. 16, 726-732.
9. Hornsleth A, Jankowski M (1990): Sensitive enzyme immunoassay for the rapid diagnosis of influenza A virus infections in clinical specimens. Res. Virol. 141, 373-384.
10. Kaverin N, Rudneva I, Govorkova E, Timofeeva T, Shilov A, Kochergin-Nikitsky K, Krylov P, Webster R (2007): Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies. J. Virol. 81, 12911-12917.
11. Koudstaal W, Koldijk M, Brakenhoff J, Cornelissen L, Weverling G, Friesen R, Goudsmit J (2009): Pre-and postexposure use of human monoclonal antibody against H5N1 and H1N1 influenza virus in mice: Viable alternative to oseltamivir. J. Infect. Dis. 200, 1870-1873.
12. Kushch A, Klimova R, Masalova O, Fedorova N, Botikov A, Fediakina I, Burtseva E, Isaeva E, Deriabin P, Ľvov D (2008): Monoclonal antibodies to highly pathogenic avian influenza A(H5N1) strain isolated in the Russian Federation: development and properties. Vopr. Virusol. 53, 9-14 (in Russian).
13. Ľvov DK, Kaverin NV (2008): Avian influenza in Northern Eurasia. In Klenk H-D, Matrosovich MN, Stech J (Eds): Avian Influenza. Monogr. Virol. Vol. 27. Karger, Switzerland, pp. 41-58.
14. Ľvov DK, Zhchelkanov MIu, Vlasov NA, Prilipov AG, Deriabin PG, Fediakina IT, Galkina IV, Zaberezhnyǐ AD, Liapina OV, Shliapnikova OV, Kireev DE, Fesenko EE, Kalmykov MV, Vitkova ON, Morozova TN, Proshina ES, Grebennikova TV, Akanina DS, Samokhvalov EI, Al'khovskiǐ SV, Volkov VA, Semenov VI, Gaponov VV, Shmakov NI, Kushnir AT, Kazarian AS, Starikov NS, Petrenko MS, Slavskiǐ AA, Litvin KE, Shcherbakova LO, Frolov AV, Manin TB, Umanets OA, Bandeev VV, Khvan AM, Dunaev VG, Cheledina TP, Abgarian SR, Mikhaǐlovich VM, Zasedatelev AS, Liubchenko EN, Fliagin VN, Tikhonova IF, Maslov DV, Anan'ev VIu, Baranov NI, Gorelikov VN, Iakovlev SS, Aliper TI, Nepoklonov EA, Suarez D (2008): The first break-through of the genotype 2.3.2 of high-virulence influenza A virus A/H5N1, which is new for Russia, in the Far East. Vopr. Virusol. 53, 4-8 (in Russian).
15. Masalova O, Lakina E, Abdulmedzhidova A, Atanadze S, Semiletov Yu, Shkurko T, Burkov A, Ulanova T, Pimenov V, Novikov V, Khudyakov Yu, Fields H, Kushch A (2002): Characterization of monoclonal antibodies and epitope mapping of the NS4 protein of hepatitis C virus. Immunol. Lett. 83, 187-196.
16. Nakane P, Kawaoi A (1974): Peroxidase-labeled antibody. A new method of conjugation. J. Histochem. Cytochem. 22, 1084-1091.
17. Peiris J, de Jong M, Guan Y (2007): Avian influenza virus (H5N1): a threat to human health. Clin. Microbiol. Rev. 20, 243-267.
18. Prabhu N, Prabakaran M, Ho H, Velumani S, Qiang J, Goutama M, Kwang J (2009a): Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection. J. Virol. 83, 2553-2562.
19. Prabhu N, Prabakaran M, Hongliang Q, He F, Ho H, Qiang J, Goutama M, Lim A, Hanson B, Kwang J (2009b): Prophylactic and therapeutic efficacy of a chimeric monoclonal antibody specific for H5 haemagglutinin against lethal H5N1 influenza. Antivir. Ther. 14, 911-921.
20. Reed L, Muench H (1938): A simple method for estimating fifty percent end-points. Am. J. Hyg. 27, 493-497.
21. Rudneva I, Kushch A, Masalova O, Timofeeva T, Klimova R, Shilov A, Ignatieva A, Krylov P, Kaverin N (2010): Antigenic epitopes in the hemagglutinin of Qinghai-type influenza H5N1 virus. Viral Immunol. 23, 181-187.
22. Scalia G, Halonen PE, Condorelli F, Mattila ML, Hierholzer JC (1995): Comparison of monoclonal biotin-avidin enzyme immunoassay and monoclonal time-resolved fluoroimmunoassay in detection of respiratory virus antigens. Clin. Diagn. Virol. 3, 351-359.
23. Smith G, Naipospos T, Nguyen T, de Jong M, Vijaykrishna D, Usman T, Hassan S, Nguyen T, Dao T, Bui N, Leung Y, Cheung C, Rayner J, Zhang J, Zhang L, Poon L, Li K, Nguyen V, Hien T, Farrar J, Webster R, Chen H, Peiris J, Guan Y (2006): Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam. Virology 350, 258-268.
24. Spackman E (2008): A brief introduction to the avian influenza virus. Methods Mol. Biol. 436, 1-6.
25. Subbarao K, Klimov A, Katz J, Regnery H, Lim W, Hall H, Perdue M, Swayne D, Bender C, Huang J, Hemphill M, Rowe T, Shaw M, Xu X, Fukuda K, Cox N (1998): Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279, 393-396.
26. Sun L, Lu X, Li C, Wang M, Liu Q, Li Z, Hu X, Li J, Liu F, Li Q, Belser JA, Hancock K, Shu Y, Katz J, Liang M, Li D (2009): Generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza A H5N1 viruses. PLoS One 4, e5476.
27. Tkáčová M, Varečková E (1996): A sensitive one-step immunocapture EIA for rapid diagnosis of influenza A. J. Virol. Methods 60, 65-71.
28. Varečková E, Tkáčová M, Mattila ML, Mucha V, Waris ME (2001): Comparison of 44/107L one-step immunocapture enzyme-immunoassay and time-resolved fluoroimmunoassay for influenza A diagnosis. J. Virol. Methods 91, 131-137.
29. Webster R, Govorkova E (2006): H5N1 influenza-continuing evolution and spread. N. Engl. J. Med. 355, 2174-2177.
30. World Health Organization (2004): Laboratory Biosafety Manual. 3rd ed. World Health Organization, Geneva, Switzerland.
31. World Health Organization (2008): Toward a unified nomenclature system for highly pathogenic avian influenza virus (H5N1). Emerg. Infect. Dis. 14, e1.
32. World Health Organization Epidemic and Pandemic Alert and Response (2010): Online report: Cumulative number of confirmed human cases of avian influenza A(H5N1) reported to WHO on 8 June 2010 Available from http://www.who.int/csr/disease/avian_influenza/country/cases_table_2010_06_08/en.
33. Wu WL, Chen Y, Wang P, Song W, Lau SY, Rayner JM, Smith GJ, Webster RG, Peiris JS, Lin T, Xia N, Guan Y, Chen H (2008): Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. J. Virol. 82, 1798-1807.
34. Yang M, Berhane Y, Salo T, Li M, Hole K, Clavijo A (2008): Development and application of monoclonal antibodies against avian influenza virus nucleoprotein. J. Virol. Methods 147, 265-274.
35. Yang M, Clavijo A, Graham J, Salo T, Hole K, Berhane Y (2009): Production and diagnostic application of monoclonal antibodies against influenza virus H5. J. Virol. Methods 162, 194-202.
36. Zhang A, Jin M, Liu F, Guo X, Hu Q, Han L, Tan Y, Chen H (2006): Development and evaluation of a DAS-ELISA for rapid detection of avian influenza viruses. Avian Dis. 50, 325-330.