Biological and genetic factors associated with ABCB1 and pregnane-X-receptor expressions in peripheral blood mononuclear cells in the STANISLAS cohort

Drug Metabolism and Drug Interactions

Volumn 26, Issue 1, 2011, Pages 27-32

  Jeannesson, Elise ^a,b   Siest, Gerard ^a   Herbeth, Bernard ^a   Albertini, Laetitia ^a   Shahabi, Payman ^a   Pfister, Michele ^a   Visvikis Siest, Sophie ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b INSERM   (France)

Author keywords

ABCB1; lipids; mRNA; peripheral blood mononuclear cells (PBMCs); pregnane X receptor (PXR)

Indexed keywords

APOLIPOPROTEIN; BIOLOGICAL FACTOR; GAMMA GLUTAMYLTRANSFERASE; LIPID; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PREGNANE X RECEPTOR;

ADULT; ARTICLE; BODY MASS; FEMALE; HEREDITY; HUMAN; HUMAN CELL; LIPID BLOOD LEVEL; LYMPHOCYTE COUNT; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE;

AGE FACTORS; APOLIPOPROTEINS; BODY MASS INDEX; FEMALE; GENE EXPRESSION; GENETIC VARIATION; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPIDS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; P-GLYCOPROTEIN; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS;

EID: 79956372206     PISSN: 07925077     EISSN: 07925077     Source Type: Journal    
DOI: 10.1515/DMDI.2011.102     Document Type: Article

References (32)

1. Elbekai RH, El-Kadi AO. Cytochrome P450 enzymes: central players in cardiovascular health and disease. Pharmacol Ther 2006;112:564-87. (Pubitemid 44488710)
2. Siest G, Jeannesson E, Marteau JB, Samara A, Marie B, Pfister M, et al. Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects. Drug Metab Dispos 2008;36:182-9.
3. Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. Atherosclerosis 2007; 191:63-72. (Pubitemid 46227430)
4. Wibaut-Berlaimont V, Randi AM, Mandryko V, Lunnon MW, Haskard DO, Naoumova RP. Atorvastatin affects leukocyte gene expression in dyslipidemia patients: in vivo regulation of hemo-stasis, inflammation and apoptosis. J Thromb Haemost 2005; 3:677-85. (Pubitemid 41647880)
5. Moore DF, Li H, Jeffries N, Wright V, Cooper RA Jr, Elkahloun A, et al. Using peripheral blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: a pilot investigation. Circulation 2005;111:212-21. (Pubitemid 40139734)
6. Marzolini C, Paus E, Buclin T, Kim RB. Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther 2004;75:13-33. (Pubitemid 38130115)
7. Siest G, Jeannesson E, Marteau JB, Samara A, Pfister M, Visvikis-Siest S. Drug metabolizing enzymes and transporters mRNA in peripheral blood mononuclear cells of healthy subjects: biological variations and importance of pre-analytical steps. Curr Drug Metab 2009;10:410-9.
8. Matic M, Mahns A, Tsoli M, Corradin A, Polly P, Robertson GR. Pregnane X receptor: promiscuous regulator of detoxification pathways. Int J Biochem Cell Biol 2007;39:478-83. (Pubitemid 46096787)
9. Albermann N, Schmitz-Winnenthal FH, Z'Graggen K, Volk C, Hoffmann MM, Haefeli WE, et al. Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem Pharmacol 2005;70:949-58. (Pubitemid 41138860)
10. Owen A, Chandler B, Back DJ, Khoo SH. Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA. Antivir Ther 2004;9:819-21. (Pubitemid 39434346)
11. Lamba J, Lamba V, Schuetz E. Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics. Curr Drug Metab 2005;6:369-83. (Pubitemid 41086769)
12. Leschziner GD, Andrew T, Pirmohamed M, Johnson MR. ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research. Pharmacogenomics J 2007;7:154-79. (Pubitemid 46794925)
13. Mizutani T, Masuda M, Nakai E, Furumiya K, Togawa H, Nakamura Y, et al. Genuine functions of P-glycoprotein (ABCB1). Curr Drug Metab 2008;9:167-74. (Pubitemid 351461005)
14. Aye IL, Singh AT, Keelan JA. Transport of lipids by ABC proteins: interactions and implications for cellular toxicity, viability and function. Chem Biol Interact 2009;180:327-39.
15. Leon C, Sachs-Barrable K, Wasan KM. Does p-glycoprotein play a role in gastrointestinal absorption and cellular transport of dietary cholesterol? Drug Dev Ind Pharm 2006;32:779-82. (Pubitemid 44181203)
16. Garrigues A, Escargueil AE, Orlowski S. The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane. Proc Natl Acad Sci USA 2002;99: 10347-52.
17. Luker GD, Nilsson KR, Covey DF, Piwnica-Worms D. Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. J Biol Chem 1999;274:6979-91.
18. Tous M, Ribas V, Ferre N, Escola-Gil JC, Blanco-Vaca F, Alonso-Villaverde C, et al. Turpentine-induced inflammation reduces the hepatic expression of the multiple drug resistance gene, the plasma cholesterol concentration and the development of atherosclerosis in apolipoprotein E deficient mice. Biochim Biophys Acta 2005;1733:192-8. (Pubitemid 40603662)
19. Voshol PJ, Havinga R, Wolters H, Ottenhoff R, Princen HM, Oude Elferink RP, et al. Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice. Gastroenterology 1998;114:1024-34. (Pubitemid 28217570)
20. Jeannesson E, Siest G, Bastien B, Albertini L, Aslanidis C, Schmitz G, et al. Association of ABCB1 gene polymorphisms with plasma lipid and apolipoprotein concentrations in the STANISLAS cohort. Clin Chim Acta 2009;403:198-202.
21. Siest G, Visvikis S, Herbeth B, Gueguen R, Vincent-Viry M, Sass C, et al. Objectives, design and recruitment of a familial and longitudinal cohort for studying gene-environment interactions in the field of cardiovascular risk: the Stanislas cohort. Clin Chem Lab Med 1998;36:35-42.
22. Samara A, Pfister M, Marie B, Visvikis-Siest S. Visfatin, low-grade inflammation and body mass index (BMI). Clin Endocrinol 2008;69:568-74.
23. Jeannesson E, Albertini L, Siest G, Gomes AM, Ribeiro V, Aslanidis C, et al. Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population. Fundam Clin Pharmacol 2007;21:411-8. (Pubitemid 47084031)
24. Marteau JB, Mohr S, Pfister M, Visvikis-Siest S. Collection and storage of human blood cells for mRNA expression profiling: a 15-month stability study. Clin Chem 2005;51:1250-2. (Pubitemid 43079404)
25. Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Relman DA, et al. Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci USA 2003;100:1896-901. (Pubitemid 36254545)
26. Mangoni AA. The impact of advancing age on P-glycoprotein expression and activity: current knowledge and future directions. Expert Opin Drug Metab Toxicol 2007;3:315-20.
27. Markova S, Nakamura T, Sakaeda T, Makimoto H, Uchiyama H, Okamura N, et al. Genotype-dependent down-regulation of gene expression and function of MDR1 in human peripheral blood mononuclear cells under acute inflammation. Drug Metab Pharmacokinet 2006;21:194-200.
28. Owen A, Chandler B, Bray PG, Ward SA, Hart CA, Back DJ, et al. Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4. J Virol 2004;78:12022-9. (Pubitemid 39390786)
29. Storch CH, Klimm HD, Heinrich T, Haefeli WE, Weiss J. Plasma LDL cholesterol has no impact on P-glycoprotein (MDR1/ABCB1) activity in human peripheral blood mononuclear cells. Naunyn Schmiedebergs Arch Pharmacol 2007;376: 135-43.
30. Oselin K, Nowakowski-Gashaw I, Mrozikiewicz PM, Wolbergs D, Pahkla R, Roots I. Quantitative determination of MDR1 mRNA expression in peripheral blood lymphocytes: a possible role of genetic polymorphisms in the MDR1 gene. Eur J Clin Invest 2003;33:261-7. (Pubitemid 36411546)
31. Ichihara S, Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, et al. Association of a polymorphism of ABCB1 with obesity in Japanese individuals. Genomics 2008;91:512-6.
32. Troost J, Albermann N, Emil Haefeli W, Weiss J. Cholesterol modulates P-glycoprotein activity in human peripheral blood mononu-clear cells. Biochem Biophys Res Commun 2004;316:705-11. (Pubitemid 38368010)