Decline of sperm quality and testicular function in male mice during chronic low-dose exposure to microcystin-LR

Reproductive Toxicology

Volumn 31, Issue 4, 2011, Pages 551-557

  Chen, Yu ^a   Xu, Jun ^b   Li, Yan ^a,b   Han, Xiaodong ^a  

^a NANJING UNIVERSITY   (China)

^b JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Chronic low dose; Male reproductive system; Microcystin LR; Toxicity

Indexed keywords

DRINKING WATER; FOLLITROPIN RELEASING FACTOR; LUTEINIZING HORMONE; MICROCYSTIN LR; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; LEYDIG CELL; LONG TERM EXPOSURE; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; REPRODUCTIVE TOXICITY; SEMEN ABNORMALITY; SEMEN ANALYSIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS FUNCTION; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL; TOXICITY TESTING;

ANIMALS; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLLICLE STIMULATING HORMONE; IN SITU NICK-END LABELING; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; MICE; MICROCYSTINS; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTIS; TESTOSTERONE; TIME FACTORS; WATER POLLUTANTS;

MUS;

EID: 79956369884     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.02.006     Document Type: Article

References (23)

1. Carmichael W.W., Azevedo S.M., An J.S., Molica R.J., Jochimsen E.M., Lau S., et al. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins. Environ Health Perspect 2001, 109(7):663-668.
2. Harada K. Recent advances of toxic cyanobacteria researches. J Health Sci 1999, 45(3):150-165.
3. Backer L.C., McNeel S.V., Barber T., Kirkpatrick B., Williams C., Irvin M., et al. Recreational exposure to microcystins during algal bloomsin two California lakes. Toxicon 2009.
4. Song L., Chen W., Peng L., Wan N., Gan N., Zhang X. Distribution and bioaccumulation of microcystins in water columns: a systematic investigation into the environmental fate and the risks associated with microcystins in Meiliang Bay. Lake Taihu Water Res 2007, 41(13):2853-2864.
5. Huang S.M., Zhang S., Zhang Y., Zheng J. Review on toxicity and detecting methods of microcystins in aquatic environment. J Anhui Agric Sci 2007, 35(25):7767-7769.
6. Xie L., Xie P., Ozawa K., Honma T., Yokoyama A., Park H.D. Dynamics of microcystins-LR and -RR in the phytoplanktivorous silver carp in a sub-chronic toxicity experiment. Environ Pollut 2004, 127(3):431-439.
7. Chen J., Xie P. Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in two freshwater shrimps, Palaemon modestus and Macrobrachium nipponensis, from a large shallow, eutrophic lake of the subtropical China. Toxicon 2005, 45(5):615-625.
8. Chen J., Xie P., Guo L., Zheng L., Ni L. Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in a freshwater snail (Bellamya aeruginosa) from a large shallow, eutrophic lake of the subtropical China. Environ Pollut 2005, 134(3):423-430.
9. Funari E., Testai E. Human health risk assessment related to cyanotoxins exposure. Crit Rev Toxicol 2008, 38(2):97-125.
10. Monks N.R., Liu S., Xu Y., Yu H., Bendelow A.S., Moscow J.A. Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells. Mol Cancer Ther 2007, 6(2):587-598.
11. Ito E., Kondo F., Harada K. Intratracheal administration of microcystin-LR, and its distribution. Toxicon 2001, 39(2-3):265-271.
12. Yu S.Z. Primary prevention of hepatocellular carcinoma. J Gastroenterol Hepatol 1995, 10(6):674-682.
13. Solter P., Liu Z., Guzman R. Decreased hepatic ALT synthesis is an outcome of subchronic microcystin-LR toxicity. Toxicol Appl Pharmacol 2000, 164(2):216-220.
14. Li Y., Sheng J., Sha J., Han X. The toxic effects of microcystin-LR on the reproductive system of male rats in vivo and in vitro. Reprod Toxicol 2008, 26(3-4):239-245.
15. Emilson L.B., Dougherty K.A., Cockett A.T., Urry R.L. Simultaneous determination of human sperm morphology and viability: simple office technique. Urology 2004, 11(5):488-491.
16. Swan S.H., Elkin E.P. Declining semen quality: can the past inform the present?. Bioessays 1999, 21(7):614-621.
17. Xiong Q., Xie P., Li H., Hao L., Li G., Qiu T., et al. Involvement of Fas/FasL system in apoptotic signaling in testicular germ cells of male Wistar rats injected i.v. with microcystins. Toxicon 2009, 54(1):1-7.
18. Arambepola N.K., Bunick D., Cooke P.S. Thyroid hormone effects on androgen receptor messenger RNA expression in rat Sertoli and peritubular cells. J Endocrinol 1998, 156(1):43-50.
19. Buzzard J.J., Morrison J.R., O'Bryan M.K., Song Q., Wreford N.G. Developmental expression of thyroid hormone receptors in the rat testis. Biol Reprod 2000, 62(3):664-669.
20. Liu Y., Xie P., Qiu T., Li H.Y., Li G.Y., Hao L., et al. Microcystin extracts induce ultrastructural damage and biochemical disturbance in male rabbit testis. Environ Toxicol 2010, 25(1):9-17.
21. Anita H., Matthew P. Structural and histological analysis of Leydig cell steroidogenic function the Leydig cell in health and disease 2007, Humana Press, Duesseldorf, p. 33-45. 2nd ed.
22. Fischer W.J., Altheimer S., Cattori V., Meier P.J., Dietrich D.R., Hagenbuch B. Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin. Toxicol Appl Pharmacol 2005, 203(3):257-263.
23. MacKintosh C., Beattie K.A., Klumpp S., Cohen P., Codd G.A. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett 1990, 264(2):187-192.