Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats

Archives of Toxicology

Volumn 85, Issue 5, 2011, Pages 513-523

  Carr, Tracy L ^a   Ciurlionis, Rita ^a   Milicic, Ivan ^a   Whitney, Katharine ^a   Liguori, Michael J ^a   Warder, Scott E ^a   Strakhova, Marina I ^a   Blomme, Eric A G ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Dibromoacetic acid; Halogenated acids; Rat; Spermiation; Testis

Indexed keywords

ANDROGEN; BROMOACETIC ACID; CHORIONIC GONADOTROPIN; CYTOCHROME P450C17; CYTOCHROME P450C17ALPHA; DIBROMOACETIC ACID; MESSENGER RNA; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LEYDIG CELL; MALE; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPERMATOGENESIS; STEROIDOGENESIS; TARGET CELL; TESTIS INJURY; TOXICITY TESTING;

ACETIC ACIDS; ANIMALS; CHORIONIC GONADOTROPIN; DOWN-REGULATION; GENE EXPRESSION PROFILING; HUMANS; LEYDIG CELLS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPERMATOGENESIS; STEROID 17-ALPHA-HYDROXYLASE; TESTICULAR DISEASES; TESTIS; TESTOSTERONE;

RATTUS; STOCHOMYS LONGICAUDATUS;

EID: 79956355957     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-010-0600-2     Document Type: Article

References (37)

1. BT Akingbemi CM Sottas AI Koulova GR Klinefelter MP Hardy 2004 Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells Endocrinology 145 592 603 14605012 10.1210/en.2003-1174 1:CAS:528:DC%2BD2cXovFSgtw%3D%3D (Pubitemid 38183801)
2. M Ayub MJ Levell 1987 Inhibition of testicular 17 alpha-hydroxylase and 17, 20-lyase but not 3 beta-hydroxysteroid dehydrogenase-isomerase or 17 beta-hydroxysteroid oxidoreductase by ketoconazole and other imidazole drugs J Steroid Biochem 28 521 531 2824931 10.1016/0022-4731(87)90511-5 1:CAS:528:DyaL1cXhsFOqtA%3D%3D (Pubitemid 18043975)
3. G Bagchi DJ Waxman 2008 Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression Int J Androl 31 269 274 18179559 10.1111/j.1365-2605.2007.00846.x 1:CAS:528:DC%2BD1cXltFCrsbo%3D
4. SK Balchak JM Hedge AS Murr ML Mole JM Goldman 2000 Influence of the drinking water disinfection by-product dibromoacetic acid on rat estrous cyclicity and ovarian follicular steroid release in vitro Reprod Toxicol 14 533 539 11099878 10.1016/S0890-6238(00)00104-0 1:CAS:528:DC%2BD3cXotlGjtLg%3D
5. K Bay S Hartung R Ivell M Schumacher D Jurgensen N Jorgensen M Holm NE Skakkebaek AM Andersson 2005 Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders: relationship to the luteinizing hormone-testosterone axis J Clin Endocrinol Metab 90 3410 3418 15755855 10.1210/jc.2004-2257 1:CAS:528:DC%2BD2MXkvFClt78%3D (Pubitemid 41014305)
6. A Beardsley L O'Donnell 2003 Characterization of normal spermiation and spermiation failure induced by hormone suppression in adult rats Biol Reprod 68 1299 1307 12606480 10.1095/biolreprod.102.009811 1:CAS:528:DC%2BD3sXisVertbw%3D (Pubitemid 36359118)
7. Blomme EAG (2008) Toxicogenomics: applications to in vivo toxicology. In: Semizarov D, Blomme EAG (eds) Genomics in drug discovery and development. Wiley, Hoboken, pp 219-292
8. Blomme EAG, Semizarov D, Waring JF (2008) Toxicogenomics in preclinical development. In: Gad SC (ed) Preclinical development handbook-toxicology. Wiley, Hoboken, pp 867-910
9. RE Chapin RN Wine MW Harris CH Borchers JK Haseman 2001 Structure and control of a cell-cell adhesion complex associated with spermiation in rat seminiferous epithelium J Androl 22 1030 1052 11700851 1:CAS:528: DC%2BD3MXotlyns78%3D (Pubitemid 33020325)
10. L Dodds W King C Woolcott J Pole 1999 Trihalomethanes in public water supplies and adverse birth outcomes Epidemiology 10 233 237 10230830 10.1097/00001648-199905000-00007 1:STN:280:DyaK1M3ksFylsw%3D%3D (Pubitemid 29187755)
11. A El Shennawy RJ Gates LD Russell 1998 Hormonal regulation of spermatogenesis in the hypophysectomized rat: cell viability after hormonal replacement in adults after intermediate periods of hypophysectomy J Androl 19 320 334 9639049 1:STN:280:DyaK1czgtV2hsg%3D%3D (Pubitemid 28265108)
12. A Ferlin A Garolla F Rigon CL Rasi A Lenzi C Foresta 2006 Changes in serum insulin-like factor 3 during normal male puberty J Clin Endocrinol Metab 91 3426 3431 16804040 10.1210/jc.2006-0821 1:CAS:528:DC%2BD28XpslajtL8%3D (Pubitemid 44402114)
13. C Foresta A Bettella C Vinanzi P Dabrilli MC Meriggiola A Garolla A Ferlin 2004 A novel circulating hormone of testis origin in humans J Clin Endocrinol Metab 89 5952 5958 15579743 10.1210/jc.2004-0575 1:CAS:528: DC%2BD2cXhtFSitrbE (Pubitemid 39628399)
14. MD Gallagher JR Nuckols L Stallones DA Savitz 1998 Exposure to trihalomethanes and adverse pregnancy outcomes Epidemiology 9 484 489 9730025 10.1097/00001648-199809000-00003 1:STN:280:DyaK1czpslOlsA%3D%3D (Pubitemid 28387946)
15. WH Glaze JB Andelman RJ Bull RB Conolly CD Hertz RD Hood RA Pegram 1993 Determining health risks associated with disinfectants and disinfection by-products: research needs J Am Water Works Assoc 85 53 56 11538065 1:CAS:528:DyaK3sXktFGjs7k%3D
16. JM Goldman AS Murr 2002 Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway Toxicology 171 83 93 11836015 10.1016/S0300-483X(01)00565- 0 1:CAS:528:DC%2BD38XhtVKmtbs%3D (Pubitemid 34142483)
17. JM Goldman AS Murr 2003 Dibromoacetic acid-induced elevations in circulating estradiol: effects in both cycling and ovariectomized/steroid-primed female rats Reprod Toxicol 17 585 592 14555197 10.1016/S0890-6238(03)00068-6 1:CAS:528:DC%2BD3sXnvVOgtLw%3D (Pubitemid 37337382)
18. S Haidar PB Ehmer S Barassin C Batzl-Hartmann RW Hartmann 2003 Effects of novel 17 alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo J Steroid Biochem Mol Biol 84 555 562 12767280 1:CAS:528:DC%2BD3sXktFCqt7k%3D (Pubitemid 36588809)
19. NA Hanley WE Rainey DI Wilson SG Ball KL Parker 2001 Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential interactions in gene regulation Mol Endocrinol 15 57 68 11145739 10.1210/me.15.1.57 1:CAS:528:DC%2BD3MXktVKmsg%3D%3D (Pubitemid 32156041)
20. M Holmes JD Suarez NL Roberts ML Mole AS Murr GR Klinefelter 2001 Dibromoacetic acid, a prevalent by-product of drinking water disinfection, compromises the synthesis of specific seminiferous tubule proteins following both in vivo and in vitro exposures J Androl 22 878 890 11545302 1:CAS:528:DC%2BD3MXnt1Sqtro%3D (Pubitemid 32781278)
21. GR Klinefelter PF Hall LL Ewing 1987 Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure Biol Reprod 36 769 783 3496123 10.1095/biolreprod36.3.769 1:CAS:528:DyaL2sXktFyju7Y%3D (Pubitemid 17086439)
22. GR Klinefelter LF Strader JD Suarez NL Roberts 2002 Bromochloroacetic acid exerts qualitative effects on rat sperm: implications for a novel biomarker Toxicol Sci 68 164 173 12075119 10.1093/toxsci/68.1.164 1:CAS:528: DC%2BD38XlsVSnu7g%3D (Pubitemid 34785238)
23. GR Klinefelter LF Strader JD Suarez NL Roberts JM Goldman AS Murr 2004 Continuous exposure to dibromoacetic acid delays pubertal development and compromises sperm quality in the rat Toxicol Sci 81 419 429 15254335 10.1093/toxsci/kfh217 1:CAS:528:DC%2BD2cXns1Omu7o%3D (Pubitemid 39377972)
24. SW Krasner MJ McGuire JG Jacangelo NL Patania KM Reagan EM Aieta 1989 The occurrence of disinfection by-products in US drinking water J Am Water Works Assoc 81 41 53 1:CAS:528:DyaK3cXotlOguw%3D%3D
25. RE Linder GR Klinefelter LF Strader JD Suarez CJ Dyer 1994 Acute spermatogenic effects of bromoacetic acids Fundam Appl Toxicol 22 422 430 8050637 10.1006/faat.1994.1048 1:CAS:528:DyaK2cXivFWks7g%3D (Pubitemid 24141836)
26. RE Linder GR Klinefelter LF Strader JD Suarez NL Roberts CJ Dyer 1994 Spermatotoxicity of dibromoacetic acid in rats after 14 daily exposures Reprod Toxicol 8 251 259 8075514 10.1016/0890-6238(94)90009-4 1:CAS:528: DyaK2cXkslGru7k%3D (Pubitemid 2096844)
27. RE Linder GR Klinefelter LF Strader MG Narotsky JD Suarez NL Roberts SD Perreault 1995 Dibromoacetic acid affects reproductive competence and sperm quality in the male rat Fundam Appl Toxicol 28 9 17 8566488 10.1006/faat.1995. 1140 1:CAS:528:DyaK2MXptVCltrk%3D
28. RE Linder GR Klinefelter LF Strader DN Veeramachaneni NL Roberts JD Suarez 1997 Histopathologic changes in the testes of rats exposed to dibromoacetic acid Reprod Toxicol 11 47 56 9138633 10.1016/S0890-6238(96)00196-7 1:CAS:528:DyaK2sXhsVGltr4%3D (Pubitemid 27152419)
29. RI McLachlan L O'Donnell SJ Meachem PG Stanton DM de Kretser K Pratis DM Robertson 2002 Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys, and man Recent Prog Horm Res 57 149 179 12017541 10.1210/rp.57.1.149 1:CAS:528:DC%2BD38Xjt1Wqt7Y%3D
30. RL Melnick A Nyska PM Foster JH Roycroft GE Kissling 2007 Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice Toxicology 230 126 136 17157429 10.1016/j.tox.2006.11.006 1:CAS:528:DC%2BD2sXntlyjtw%3D%3D (Pubitemid 46109133)
31. S Nakajin JE Shively PM Yuan PF Hall 1981 Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17 alpha-hydroxylase and c17, 20-lyase) associated with one protein Biochemistry 20 4037 4042 6793062 10.1021/bi00517a014 1:CAS:528:DyaL3MXksFOjsbs%3D
32. MJ Nieuwenhuijsen MB Toledano NE Eaton J Fawell P Elliott 2000 Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review Occup Environ Med 57 73 85 10711274 10.1136/oem.57.2.73 1:CAS:528:DC%2BD3cXps12jtA%3D%3D (Pubitemid 30265451)
33. T Saether TN Tran H Rootwelt BO Christophersen TB Haugen 2003 Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis Biol Reprod 69 117 124 12606372 10.1095/biolreprod.102.014035 1:CAS:528:DC%2BD3sXkvFCnt7w%3D (Pubitemid 36806813)
34. K Saito L O'Donnell RI McLachlan DM Robertson 2000 Spermiation failure is a major contributor to early spermatogenic suppression caused by hormone withdrawal in adult rats Endocrinology 141 2779 2785 10919263 10.1210/en.141.8.2779 1:CAS:528:DC%2BD3cXnt1Cms7w%3D (Pubitemid 32250439)
35. KH Song YY Park KC Park CY Hong JH Park M Shong K Lee HS Choi 2004 The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation Mol Endocrinol 18 1929 1940 15155786 10.1210/me.2004-0043 1:CAS:528:DC%2BD2cXmtlKru7Y%3D (Pubitemid 39022610)
36. TT Turner CE Jones SS Howards LL Ewing B Zegeye GL Gunsalus 1984 On the androgen microenvironment of maturing spermatozoa Endocrinology 115 1925 1932 6541571 10.1210/endo-115-5-1925 1:CAS:528:DyaL2cXmt1aqur0%3D (Pubitemid 15206616)
37. K Waller SH Swan G DeLorenze B Hopkins 1998 Trihalomethanes in drinking water and spontaneous abortion Epidemiology 9 134 140 9504280 10.1097/00001648-199803000-00006 1:STN:280:DyaK1c7msFSnsg%3D%3D (Pubitemid 28157610)