MRG15 activates the cdc2 promoter via histone acetylation in human cells

Experimental Cell Research

Volumn 317, Issue 11, 2011, Pages 1534-1540

  Peña, AndreAna N ^a,b   Tominaga, Kaoru ^a,b   Pereira Smith, Olivia M ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Cdc2; MRG15; Normal human fibroblasts; Tip60

Indexed keywords

ANACARDIC ACID; COMPLEMENTARY DNA; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; MESSENGER RNA; MRG15 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CELL CYCLE; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA PROTEIN COMPLEX; ENZYME INHIBITION; FIBROBLAST; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION INITIATION;

MUS;

EID: 79956336145     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.02.001     Document Type: Article

References (31)

1. Bertram M.J., Berube N.G., Hang-Swanson X., Ran Q., Leung J.K., Bryce S., Spurgers K., Bick R.J., Baldini A., Ning Y., Clark L.J., Parkinson E.K., Barrett J.C., Smith J.R., Pereira-Smith O.M. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol. Cell. Biol. 1999, 19:1479-1485.
2. Marin I., Baker B.S. Origin and evolution of the regulatory gene male-specific lethal-3. Mol. Biol. Evol. 2000, 17:1240-1250.
3. Bertram M.J., Pereira-Smith O.M. Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif. Gene 2001, 266:111-121.
4. Pardo P.S., Leung J.K., Lucchesi J.C., Pereira-Smith O.M. MRG15 a novel chromodomain protein is present in two distinct multiprotein complexes involved in transcriptional activation. J. Biol. Chem. 2002, 277:50860-50866.
5. Garcia S.N., Kirtane B.M., Podlutsky A.J., Pereira-Smith O.M., Tominaga K. Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation. FEBS Lett. 2007, 581:5275-5281.
6. Tominaga K., Kirtane B., Jackson J.G., Ikeno Y., Ikeda T., Hawks C., Smith J.R., Matzuk M.M., Pereira-Smith O.M. MRG15 regulates embryonic development and cell proliferation. Mol. Cell. Biol. 2005, 25:2924-2937.
7. Kusch T., Florens L., MacDonald W.H., Swanson S.K., Glaser R.L., Yates J.R., Abmayr S.M., Washburn M.P., Workman J.L. Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science 2004, 306:2084-2087.
8. Chen M., Takano-Maruyama M., Pereira-Smith O.M., Gaufo G.O., Tominaga K. MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells. J. Neurosci. Res. 2009, 87:1522-1531.
9. Cai Y., Jin J., Tomomori-Sato C., Sato S., Sorokina I., Parmely T.J., Conaway R.C., Conaway J.W. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. J. Biol. Chem. 2003, 278:42733-42736.
10. Doyon Y., Selleck W., Lane W.S., Tan S., Cote J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol. Cell. Biol. 2004, 24:1884-1896.
11. Hayakawa T., Ohtani Y., Hayakawa N., Shinmyozu K., Saito M., Ishikawa F., Nakayama J. RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. Genes Cells 2007, 12:811-826.
12. Eisen A., Utley R.T., Nourani A., Allard S., Schmidt P., Lane W.S., Lucchesi J.C., Cote J. The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. J. Biol. Chem. 2001, 276:3484-3491.
13. Yochum G.S., Ayer D.E. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. Mol. Cell. Biol. 2002, 22:7868-7876.
14. Sun B., Hong J., Zhang P., Dong X., Shen X., Lin D., Ding J. Molecular basis of the interaction of Saccharomyces cerevisiae Eaf3 chromo domain with methylated H3K36. J. Biol. Chem. 2008, 283:36504-36512.
15. Zhang P., Du J., Sun B., Dong X., Xu G., Zhou J., Huang Q., Liu Q., Hao Q., Ding J. Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3. Nucleic Acids Res. 2006, 34:6621-6628.
16. Joshi A.A., Struhl K. Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation. Mol. Cell 2005, 20:971-978.
17. Lumpkin C.K., Knepper J.E., Butel J.S., Smith J.R., Pereira-Smith O.M. Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts. Mol. Cell. Biol. 1986, 6:2990-2993.
18. Stein G.H., Drullinger L.F., Robetorye R.S., Pereira-Smith O.M., Smith J.R. Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation. Proc. Natl Acad. Sci. USA 1991, 88:11012-11016.
19. Frank S.R., Schroeder M., Fernandez P., Taubert S., Amati B. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev. 2001, 15:2069-2082.
20. Taubert S., Gorrini C., Frank S.R., Parisi T., Fuchs M., Chan H.M., Livingston D.M., Amati B. E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Mol. Cell. Biol. 2004, 24:4546-4556.
21. Jackson J.G., Pereira-Smith O.M. Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells. Mol. Cell. Biol. 2006, 26:2501-2510.
22. Leung J.K., Berube N., Venable S., Ahmed S., Timchenko N., Pereira-Smith O.M. MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. J. Biol. Chem. 2001, 276:39171-39178.
23. Jackson J.G., Pereira-Smith O.M. p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts. Cancer Res. 2006, 66:8356-8360.
24. Sugarman J.L., Schonthal A.H., Glass C.K. Identification of a cell-type-specific and E2F-independent mechanism for repression of cdc2 transcription. Mol. Cell. Biol. 1995, 15:3282-3290.
25. Tominaga K., Pereira-Smith O.M. The genomic organization, promoter position and expression profile of the mouse MRG15 gene. Gene 2002, 294:215-224.
26. Tominaga K., Leung J.K., Rookard P., Echigo J., Smith J.R., Pereira-Smith O.M. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. J. Biol. Chem. 2003, 278:49618-49624.
27. Balasubramanyam K., Swaminathan V., Ranganathan A., Kundu T.K. Small molecule modulators of histone acetyltransferase p300. J. Biol. Chem. 2003, 278:19134-19140.
28. Bowman B.R., Moure C.M., Kirtane B.M., Welschhans R.L., Tominaga K., Pereira-Smith O.M., Quiocho F.A. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. Structure 2006, 14:151-158.
29. Zhang P., Zhao J., Wang B., Du J., Lu Y., Chen J., Ding J. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. Protein Sci. 2006, 15:2423-2434.
30. Kimura A., Horikoshi M. Tip60 acetylates six lysines of a specific class in core histones in vitro. Genes Cells 1998, 3:789-800.
31. Cai Y., Jin J., Swanson S.K., Cole M.D., Choi S.H., Florens L., Washburn M.P., Conaway J.W., Conaway R.C. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J. Biol. Chem. 2010, 285:4268-4272.