Cardiovascular physiology at high altitude

Journal of the Royal Army Medical Corps

Volumn 157, Issue 1, 2011, Pages 23-28

  Hooper, T ^a   Mellor, A ^b  

^a UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^b JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALTITUDE; ALTITUDE DISEASE; BLOOD PRESSURE; CARDIOVASCULAR FUNCTION; EXERCISE; HEART OUTPUT; HEART RATE; HUMAN; LUNG CIRCULATION; MOUNTAINEERING; PATHOPHYSIOLOGY; PHYSIOLOGY; PLASMA VOLUME; PULMONARY HYPERTENSION; REVIEW;

ALTITUDE; ALTITUDE SICKNESS; BLOOD PRESSURE; CARDIAC OUTPUT; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; HEART RATE; HUMANS; HYPERTENSION, PULMONARY; MOUNTAINEERING; PHYSICAL EXERTION; PLASMA VOLUME; PULMONARY CIRCULATION;

EID: 79956323307     PISSN: 00358665     EISSN: None     Source Type: Journal    
DOI: 10.1136/jramc-157-01-04     Document Type: Article

References (30)

1. Reeves JT, Groves BM, Sutton JR et al. Operation Everest II: preservation of cardiac function at extreme altitude. J Appl Physiol 1987;63(2):531-539
2. Richalet J P. Operation Everest III: COMEX '97. High Alt Med Biol 2010;11(2):121-132
3. Pugh LG, Gill MB, Lahiri S, Milledge JS, Ward M P, West JB. Muscular Exercise at Great Altitudes. J Appl Physiol 1964;19:431-440
4. Richalet J P, Merlet P, Bourguignon M et al. MIBG scintigraphic assessment of cardiac adrenergic activity in response to altitude hypoxia. J Nucl Med 1990;31(1):34-37
5. Reeves JT, Groves BM, Cymerman A et al. Operation Everest II: cardiac filling pressures during cycle exercise at sea level. Respir Physiol 1990;80(2-3):147-154
6. Arias-Stella JTM. Anatomy of the coronary circulation at high altitude. In High altitude physiology: Cardiac and respiratory aspects (eds Porter R, Knight J). Churchill Livingstone. 1971. pp 149-157
7. Marticorena E RL, Severino J, Galvez J, Penaloza D. Systemic blood pressure in white men born at sea level: Changes after long residence in high altitudes. Am J Cardiol 1969;23:364-368
8. Hooper TJ, Levett DZ, Grocott M, Mellor AJ. Resting and exercising cardiorespiratory variables and acute mountain sickness. J R Nav Med Serv 2010; 96(1): 6-12
9. Rhodes HL, Chesterman K, Chan C et al. Systemic blood pressure, arterial stifness and pulse waveform analysis at altitude. J R Army Med Corps 2011; 157(1): 110-113
10. Vogel JA, Hartley LH, Cruz JC. Cardiac output during exercise in altitude natives at sea level and high altitude. J Appl Physiol 1974;36:173-176
11. Read J, Fowler K T. Efect of Exercise on Zonal Distribution of Pulmonary Blood Flow. J Appl Physiol 1964;19:672-678
12. Groves BM, Reeves J T, Sutton JR et al. Operation Everest II: elevated high-altitude pulmonary resistance unresponsive to oxygen. J Appl Physiol 1987;63(2):521-530
13. Barer GR, Howard P, Shaw JW. Stimulus-response curves for the pulmonary vascular bed to hypoxia and hypercapnia. J Physiol 1970;211:139-155
14. Anand IS, Prasad BA, Chugh SS et al. Effect of inhaled nitric oxide and oxygen in high-altitude pulmonary oedema. Circulation 1998; 98:2441-2445
15. Barnett CF, Machado R F. Sildenafil in the treatment of pulmonary hypertension. Vasc Health Risk Manag 2006; 2(4):411-422
16. Herrera EA, Ebensperger G, Krause BJ et al. Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep. Pediatr Res 2008; 63(2):169-175
17. Honig A. Electrolytes, body fluid volumes and renal function in acute hypoxic hypoxia. Acta Physiol Pol 1979; 30(18 Suppl):93-125
18. Honig A. Peripheral arterial chemoreceptors and reflex control of sodium and water homeostasis. Am J Physiol 1989; 257(6 Pt 2):R1282-R1302
19. Toth M, Vuorinen KH, Vuolteenaho O et al. Hypoxia stimulates release of ANP and BNP from perfused rat ventricular myocardium. Am J Physiol 1994; 266(4 Pt 2):H1572-H1580
20. Feddersen B, Ausserer H, Haditsch B, Frisch H, Noachtar S, Straube A. Brain natriuretic peptide at altitude: relationship to diuresis, natriuresis, and mountain sickness. Aviat Space Environ Med 2009; 80(2):108-111
21. Pugh LG. Man at high altitude: studies carried out in the Himalaya. Sci Basis Med Annu Rev 1964:32-54
22. Calbet JA, Radegran G, Boushel R, Sondergaard H, Saltin B, Wagner PD. Effect of blood haemoglobin concentration on V(O2max) and cardiovascular function in lowlanders acclimatised to 5260 m. J Physiol 2002 1;545(Pt 2):715-728
23. Calbet JA, Lundby C. Air to muscle O2 delivery during exercise at altitude. High Alt Med Biol 2009; 10(2):123-134
24. West JB. Diffusion at high altitude. Fed Proc 1982;41(6):2128-2130
25. Lundby C, Pilegaard H, Andersen JL, van Hall G, Sander M, Calbet JA. Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle. J Exp Biol 2004; 207(Pt 22):3865-3871
26. Cibella F, Cuttitta G, Romano S, Grassi B, Bonsignore G, Milic-Emili J. Respiratory energetics during exercise at high altitude. J Appl Physiol 1999;86(6):1785-1792
27. Roach RC, Houston CS, Honigman B, et al. How well do older persons tolerate moderate altitude? West J Med 1995;162(1):32-36
28. Levine BD, Zuckerman JH, deFilippi CR. Effect of high-altitude exposure in the elderly: the Tenth Mountain Division study. Circulation 1997 19;96(4):1224-1232
29. Halhuber MJ HE, Inama AK, Jungmann H. Does altitude cause exhaustion of the heart and coronary system? Indications and contraindications for cardiac patients at altitude. In Rivolier RJ, Ceretelli P, Foray J, Segantini P. Eds. High Altitude Deterioration. Karger 1985 pp 192-200
30. Luks AM. Should travelers with hypertension adjust their medications when traveling to high altitude? High Alt Med Biol 2009; 10(1):11-15