A 2D-QSPR approach to predict blood-brain barrier penetration of drugs acting on the central nervous system

Brazilian Journal of Pharmaceutical Sciences

Volumn 46, Issue 4, 2010, Pages 741-751

  de Sá, Matheus Malta ^a   Pasqualoto, Kerly Fernanda Mesquita ^a   Rangel Yagui, Carlota de Oliveira ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Benzodiazepines; Blood brain barrier; Calculated n octanol water partition coefficient (ClogP); Two dimensional quantitative structure property relationships (2D QSPR)

Indexed keywords

5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A]THIENO[2,3 F][1,4]DIAZEPINE 3 CARBOXYLIC ACID TERT BUTYL ESTER; 7 CHLORO 5,6 DIHYDRO 3 (5 ISOPROPYL 1,2,4 OXADIAZOL 3 YL) 5 METHYL 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPIN 6 ONE; ALPHA HYDROXYMIDAZOLAM; ALPRAZOLAM; AMITRIPTYLINE; ASENAPINE; BELOXEPIN; BRETAZENIL; CARBAMAZEPINE; CENTRAL NERVOUS SYSTEM AGENTS; CLOBAZAM; DESIPRAMINE; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; IMIPRAMINE; MIANSERIN; MIDAZOLAM; MIRTAZAPINE; NORCLOBAZAM; NORDAZEPAM; OCTANOL; ORG 30526; ORG 32104; OXAZEPAM; TRIAZOLAM; UNCLASSIFIED DRUG; WATER;

ARTICLE; BLOOD BRAIN BARRIER; CORRELATION COEFFICIENT; DRUG PENETRATION; DRUG STRUCTURE; EXTERNAL VALIDITY; PARTITION COEFFICIENT; POLARIZATION; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTITATIVE STRUCTURE PROPERTY RELATION;

EID: 79956311103     PISSN: 19848250     EISSN: 21759790     Source Type: Journal    
DOI: None     Document Type: Article

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