Lens-free optical tomographic microscope with a large imaging volume on a chip

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 18, 2011, Pages 7296-7301

  Isikman, Serhan O ^a   Bishara, Waheb ^a   Mavandadi, Sam ^a   Yu, Frank W ^a   Feng, Steve ^a   Lau, Randy ^a   Ozcan, Aydogan ^a,b  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CAENORHABDITIS ELEGANS; LENS FREE OPTICAL MICROSCOPY; MEDICAL RECORD; MICROSCOPY; NONHUMAN; OPTICAL TOMOGRAPHY; PRIORITY JOURNAL; SENSOR; TOMOGRAPHY;

ANIMALS; CAENORHABDITIS ELEGANS; HOLOGRAPHY; MICROSCOPY; TOMOGRAPHY;

CAENORHABDITIS ELEGANS;

EID: 79956297619     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1015638108     Document Type: Article

References (61)

1. Melton L (2005) Imaging: The big picture. Nature 437:775-779.
2. Dittrich PS, Manz A (2006) Lab-on-a-chip:microfluidics in drug discovery. Nat Rev Drug Discov 5:210-218.
3. Squires TM, Quake SR (2005) Microfluidics: Fluid physics at the nanoliter scale Rev. Mod Phys 77:977-1026. (Pubitemid 43272528)
4. Whitesides G (2006) The origins and the future of microfluidics. Nature 442:368-373.
5. Haeberle S, Zengerle R (2007) Microfluidic platforms for lab-on-a-chip applications. Lab Chip 7:1094-1110. (Pubitemid 47295976)
6. Chin CD, Linder V, Sia SK (2007) Lab-on-a-chip devices for global health: Past studies and future opportunities. Lab Chip 7:41-57. (Pubitemid 46016024)
7. Chabert M, Viovy JL (2008) Microfluidic high-throughput encapsulation and hydrodynamic self-sorting of single cells. Proc Natl Acad Sci USA 105:3191-3196. (Pubitemid 351723530)
8. Oheim M (2007) High-throughput microscopy must re-invent the microscope rather than speed up its functions. Brit J Pharmacol 152:1-4.
9. Rohde CB, Zeng F, Gonzalez-Rubio R, Matthew A, Yanik MF (2007) Microfluidic system for on-chip high-throughput whole-animal sorting and screening at subcellular resolution. Proc Natl Acad Sci USA 104:13891-13895. (Pubitemid 350003307)
10. Chung K, Crane MM, Lu H (2008) Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans. Nat Methods 5:637-643.
11. Hulme SE, et al. (2010) Lifespan-on-a-chip: Microfluidic chambers for performing lifelong observation of C. elegans. Lab Chip 10:589-597.
12. Sanz MA, Jong L, Tavernarakis N (2006) Caenorhabditis elegans: A versatile platform for drug discovery. Biotechnology Journal 1:1405-1418.
13. Kaletta T, Hengratner M (2006) Finding function in novel targets: C. elegans as a model organism. Nat Rev Drug Discov 5:387-399. (Pubitemid 43904931)
14. Hulme SE, Shevkoplyas SS, Apfeld J, Fontana W, Whitesides GM (2007) A microfabricated array of clamps for immobilizing and imaging C. elegans. Lab Chip 7:1515-1523.
15. Kimmel CB (1995) Stages of embryonic development of the zebrafish. Dev Dynam 203:255-310.
16. Xu W, Jericho MH, Meinertzhagen IA, Kreuzer HJ (2001) Digital in-line holography for biological applications. Proc Natl Acad Sci USA 98:11301-11305. (Pubitemid 32928723)
17. Xu W, Jericho MH, Kreuzer HJ, Meinertzhagen IA (2003) Tracking particles in four dimensions with in-line holographic microscopy. Opt Lett 28:164-166.
18. Pedrini G, Tiziani HJ (2002) Short-coherence digital microscopy by use of a lensless holographic imaging system. Appl Optics 41:4489-4496. (Pubitemid 34878969)
19. Repetto L, Piano E, Pontiggia C (2004) Lensless digital holographic microscope with light-emitting diode illumination. Opt Lett 29:1132-1134.
20. Garcia-Sucerquia J, Xu W, Jericho MH, Kreuzer HJ (2006) Immersion digital in-line holographic microscopy. Opt Lett 31:1211-1213. (Pubitemid 43901243)
21. Heng X, et al. (2006) Optofluidic microscopy - a method for implementing a high resolution optical microscope on a chip. Lab Chip 6:1274-1276. (Pubitemid 44744291)
22. Psaltis D, Quake SR, Yang C (2006) Developing optofluidic technology through the fusion of microfluidics and optics. Nature 442:381-386. (Pubitemid 44264781)
23. Lew M, Cui X, Heng X, Yang C (2007) Interference of a four-hole aperture for on-chip quantitative two-dimensional differential phase imaging. Opt Lett 32:2963-2965. (Pubitemid 351302842)
24. Gopinathan U, Pedrini G, Osten W (2008) Coherence effects in digital in-line holographic microscopy. J Opt Soc Am A 25:2459-2466.
25. Mudanyali O, et al. (2010) Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications. Lab Chip 10:1417-1428.
26. Oh C, Isikman SO, Khademhosseini B, Ozcan A (2010) On-chip differential interference contrast microscopy using lensless digital holography. Opt Express 18:4717-4726.
27. Su T, et al. (2010) Multi-angle lensless digital holography for depth resolved imaging on a chip. Opt Express 18:9690-9711.
28. Seo S, et al. (2010) High-throughput lensfree blood analysis on a chip. Anal Chem 82:4621-4627.
29. Bishara W, Su T, Coskun AF, Ozcan A (2010) Lensfree on-chip microscopy over a wide field-of-view using pixel super-resolution. Opt Express 18:11181-11191.
30. Bishara W, Zhu H, Ozcan A (2010) Holographic opto-fluidic microscopy. Opt Express 18:27499-27510.
31. Brady DJ, Choi K, Marks DL, Horisaki R, Lim S (2009) Compressive holography. Opt Express 17:13040-13049.
32. Meng H, Hussain F (1995) In-line recording and off-axis viewing technique for holographic particle velocimetry. Appl Optics 34:1827-1840.
33. Sheng J, Malkiel E, Katz J (2003) Single beam two-views holographic particle image velocimetry. Appl Optics 42:235-250.
34. Sharpe J, et al. (2002) Optical projection tomography as a tool for 3d microscopy and gene expression studies. Science 296:541-545. (Pubitemid 34408675)
35. Fauver M, Seibel EJ (2005) Three-dimensional imaging of single isolated cell nuclei using optical projection tomography. Opt Express 13:4210-4223. (Pubitemid 40899320)
36. Choi W, et al. (2007) Tomographic phase microscopy. Nat Methods 4:717-719. (Pubitemid 47338165)
37. Choi W, et al. (2008) Extended depth of focus in tomographic phasemicroscopy using a propagation algorithm. Opt Lett 33:171-173. (Pubitemid 351328272)
38. Sung Y, et al. (2009) Optical diffraction tomography for high resolution live cell imaging. Opt Express 17:266-277.
39. Fang-Yen C, et al. (2011) Video Rate Tomographic Phase Microscopy. J Biomed Opt 16:011005.
40. Debailleul M, Simon B, Georges V, Haeberle O, Lauer V (2008) Holographic microscopy and diffractivemicrotomography of transparent samples. Meas Sci Technol 19:074009.
41. Charrière F, et al. (2006) Living specimen tomography by digital holographic microscopy: Morphometry of testate amoeba. Opt Express 14:7005-7013. (Pubitemid 44188502)
42. Kuhn J, et al. (2009) Submicrometer tomography of cells by multiple wavelength digital holographic microscopy in reflection. Opt Lett 34:653-655.
43. Yu L, Kim MK (2005) Wavelength-scanning digital interference holography for tomographic three-dimensional imaging by use of the angular spectrum method. Opt Lett 30:2092-2094. (Pubitemid 41251405)
44. Huisken J, et al. (2004) Optical sectioning deep inside live embryos by selective plane illumination microscopy. Science 305:1007-1009. (Pubitemid 39071776)
45. Keller PJ, Schmidt AD, Wittbrodt J, Stelzer EHK (2008) Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy. Science 322:1065-1069.
46. Jang J, Javidi B (2003) Formation of orthoscopic three-dimensional real images in direct pickup one-step integral imaging. Opt Eng 42:1869-1870.
47. Haeberle O, Belkebir K, Giovaninni H, Sentenac A (2010) Tomorgraphic diffractive microscopy: Basics, techniques and perspectives. J Mod Optic 57:686-699.
48. Hahn J, Lim S, Choi K, Horisaki R, Brady DJ (2011) Video-rate compressive holographic microscopic tomography. Opt Express 19:7289-7298.
49. Mastronarde DN (1997) Dual-axis tomography: An approach with alignment methods that preserve resolution. J Struct Biol 120:343-352.
50. Arslan I, Tong JR, Midgley PA (2006) Reducing themissing wedge: High-resolution dual axis tomography of inorganic materials. Ultramicroscopy 106:994-1000. (Pubitemid 44485336)
51. Wedberg TC, Stamnes JJ, Singer W (1995) Comparison of the filtered backpropagation and the filtered backprojection algorithms for quantitative tomography. Appl Optics 34:6575-6581.
52. Radermacher M (2006) Weighted Back-Projection Methods. Electron Tomography: Methods for Three Dimensional Visualization of Structures in the Cell (Springer, New York), 2nd Ed,, pp 245-273.
53. Oh WY, Bouma BE, Iftimia N, Yelin R, Tearney GJ (2006) Spectrally-modulated full-field optical coherence microscopy for ultrahigh-resolution endoscopic imaging. Opt Express 18:8675-8684. (Pubitemid 44435078)
54. Long F, Peng H, Liu X, Kim KS, Myers E (2009) A 3D digital atlas of C. elegans and its application to single-cell analyses. Nat Methods 6:667-672.
55. Wolf E (1969) Three-dimensional structure determination of semi-transparent objects from holographic data. Opt Commun 1:153-156.
56. Guo P, Devaney AJ (2005) Comparison of reconstruction algorithms for optical diffraction tomography. J Opt Soc Am A 22:2338-2347. (Pubitemid 41684942)
57. Ntziachristos V (2010) Going deeper than microscopy: The optical imaging frontier in biology. Nat Methods 7:603-614.
58. Zeng F, Rohde CB, Yanik MF (2008) Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femto second-laser manipulation. Lab Chip 8:653-656. (Pubitemid 351585474)
59. Guo XS, et al. (2008) Femtosecond laser nanoaxotomy lab-on-a-chip for in-vivo nerve regeneration studies. Nat Methods 5:531-533.
60. Coskun AF, Sencan I, Su TW, Ozcan A (2011) Lensfree fluorescent on-chip imaging of transgenic Caenorhabditis elegans over an ultra-wide field-of-view. PLoS ONE 6:e15955.
61. Verhoeven D (1993) Limited-data computed tomography algorithms for the physical sciences. App Optics 32:3736-3654.