Synthesis, characterization and biodegradation of novel poly(L-lactide)/multi- walled carbon nanotube porous scaffolds for tissue engineering applications

Current Nanoscience

Volumn 7, Issue 3, 2011, Pages 323-332

  Adeli, Hassan ^a   Zein, Sharif Hussein Sharif ^a   Tan, Soon Huat ^a   Akil, Hazizan Md ^a   Ahmad, Abdul Latif ^a  

^a SCHOOL OF PHYSICS   (Malaysia)

Author keywords

Biodegradation; Multi walled carbon nanotubes; Poly(l lactide); Porous scaffold; Tissue engineering

Indexed keywords

FTIR; IN-VITRO; INTERCONNECTED POROUS STRUCTURE; INTERFACIAL INTERACTION; PHOSPHATE-BUFFERED SALINES; PLLA; POLY(L-LACTIDE); POROUS SCAFFOLD; THERMAL STABILITY;

ANODIC OXIDATION; BIODEGRADATION; BIOMECHANICS; CHEMICAL SENSORS; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; INFRARED SPECTROSCOPY; MECHANICAL PROPERTIES; MICROBIOLOGY; MULTIWALLED CARBON NANOTUBES (MWCN); POLYMER BLENDS; THERMOGRAVIMETRIC ANALYSIS; TISSUE;

SCAFFOLDS (BIOLOGY);

DIOXANE; MULTI WALLED NANOTUBE; PHOSPHATE BUFFERED SALINE; POLYLACTIDE;

ARTICLE; BIODEGRADATION; DEGRADATION; DENSITY; DIFFERENTIAL SCANNING CALORIMETRY; EXTRACTION; FREEZING; IN VITRO STUDY; INFRARED SPECTROSCOPY; NANOPORE; POROSITY; PRIORITY JOURNAL; ROOM TEMPERATURE; STRENGTH; STRUCTURE ANALYSIS; SYNTHESIS; THERMOGRAVIMETRY; THERMOSTABILITY; TISSUE ENGINEERING; VISCOSITY; YOUNG MODULUS;

EID: 79956274926     PISSN: 15734137     EISSN: 18756786     Source Type: Journal    
DOI: 10.2174/157341311795542552     Document Type: Article

References (52)

1. Mano, J.F., Vaz, C.M., Mendes, S.C., Reis, R.L., Cunha, A.M. Dynamic mechanical properties of hydroxyapatite-reinforced and porous starch-based degradable biomaterials. J. Mater. Sci. Mater. Med., 1999, 10(12), 857-862.
2. Kim, B.-S., Mooney, D.J. Development of biocompatible synthetic extracellular matrices for tissue engineering. Trends Biotechnol., 1998, 16(5), 224-230.
3. Middleton, J.C., Tipton, A.J. Synthetic biodegradable polymers as orthopedic devices. Biomaterials, 2000, 21(23), 2335-2346.
4. Madihally, S.V., Matthew, H.W.T. Porous chitosan scaffolds for tissue engineering. Biomaterials, 1999, 20(12), 1133-1142.
5. Zhou, Q., Gong, Y., Gao, C. Microstructure and mechanical properties of poly(L-lactide) scaffolds fabricated by gelatin particle leaching method. J. Appl. Polym. Sci., 2005, 98(3), 1373-1379.
6. Raghunath, J., Rollo, J., Sales, K.M., Butler, P.E., Seifalian, A.M. Biomaterials and scaffold design: Key to tissue-engineering cartilage. Biotechnol. Appl. Biochem., 2007, 46(2), 73-84.
7. Gong, Y., Zhou, Q., Gao, C., Shen, J. In vitro and in vivo degradability and cytocompatibility of poly(l-lactic acid) scaffold fabricated by a gelatin particle leaching method. Acta Biomater., 2007, 3(4), 531-540.
8. Ikada, Y., Tsuji, H. Biodegradable polyesters for medical and ecological applications. Macromol. Rapid Commun., 2000, 21(3), 117-132.
9. Thomson, R.C., Wake, M.C., Yaszemski, M.J., Mikos, A.G. Biodegradable polymer scaffolds to regenerate organs. Adv. Polym. Sci., 1995, 122, 218-274.
10. Zacchi, V., Soranzo, C., Cortivo, R., Radice, M., Brun, P., Abatangelo, G. In vitro engineering of human skin-like tissue. J. Biomed. Mater. Res., 1998, 40(2), 187-194.
11. Ishaug, S.L., Crane, G.M., Miller, M.J., Yasko, A.W., Yaszemski, M.J., Mikos, A.G. Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J. Biomed. Mater. Res., 1997, 36(1), 17-28.
12. Li, W.J., Tuan, R.S. Polymeric scaffolds for cartilage tissue engineering. In Macromol. Symp., 2005, 227, 65-75.
13. Lin, V.S., Lee, M.C., O'Neal, S., McKean, J., Paul Sung, K.L. Ligament tissue engineering using synthetic biodegradable fiber scaffolds. Tissue Eng., 1999,5(5), 443-451.
14. Sodergard, A., Stolt, M. Properties of lactic acid based polymers and their correlation with composition. Prog. Polym. Sci., 2002, 27(6), 1123-1163.
15. Auras, R., Harte, B., Selke, S. An overview of polylactides as packaging materials. Macromol. Biosci., 2004, 4(9), 835-864.
16. Reignier, J., Huneault, M.A. Preparation of interconnected poly([epsilon]- caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching. Polymer, 2006, 47(13), 4703-4717.
17. Nam, Y.S., Yoon, J.J., Park, T.G. A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive. J. Biomed. Mater. Res., 2000, 53(1), 1-7.
18. Mariani, M., Rosatini, F., Vozzi, G., Previti, A., Ahluwalia, A. Characterization of tissue-engineered scaffolds microfabricated with PAM. Tissue Eng., 2006, 12(3), 547-558.
19. Williamson, M.R., Adams, E.F., Coombes, A.G.A. Gravity spun polycaprolactone fibres for soft tissue engineering: Interaction with fibroblasts and myoblasts in cell culture. Biomaterials, 2006, 27(7), 1019-1026.
20. Hutmacher, D.W., Schantz T., Zein, I., Ng, K.W., Teoh, S.H., Tan, K.C. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J. Biomed. Mater. Res., 2001, 55(2), 203-216.
21. Murphy, M.B., Mikos, A.G. Polymer scaffold fabrication, in Principles of Tissue Engineering Robert, L., Robert, L., Joseph, V. Eds, Academic Press: Burlington, 2007, pp. 309-321.
22. Ho, M.H., Kuo, P.Y., Hsieh, H.J., Hsien, T.Y., Hou, L.T., Lai, J.Y., Wang, D.M. Preparation of porous scaffolds by using freeze-extraction and freeze- gelation methods. Biomaterials, 2004, 25(1), 129-138.
23. Yang, F., Murugan, R., Ramakrishna, S., Wang, X., Ma, Y.X., Wang, S. Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials, 2004, 25(10), 1891-1900.
24. Zhang, R., Ma, P.X. Porous poly(L-lactic acid)/apatite composites created by biomimetic process. J. Biomed. Mater. Res., 1999, 45(4), 285-293.
25. Zhang, Y., Zhang, M. Microstructural and mechanical characterization of chitosan scaffolds reinforced by calcium phosphates. J. Non-Cryst. Solids, 2001,282(2-3), 159-164.
26. Kothapalli, C.R., Shaw, M.T., Wei, M. Biodegradable HA-PLA 3-D porous scaffolds: Effect of nano-sized filler content on scaffold properties. Acta Biomater., 2005, 1(6), 653-662.
27. Kim, H.S., Park, B.H., Yoon, J.S., Jin, H.J. Thermal and electrical properties of poly(L-lactide)-graft-multiwalled carbon nanotube composites. Eur. Polym. J., 2007, 43(5), 1729-1735.
28. Abarrategi, A., Gutiérrez, M.C., Moreno-Vicente, C., Hortigüela, M.J., Ramos, V., López-Lacomba, J.L., Ferrer, M.L., del Monte, F. Multiwall carbon nanotube scaffolds for tissue engineering purposes. Biomaterials, 2008,29(1), 94-102.
29. MacDonald, R.A., Laurenzi, B.F., Viswanathan, G., Ajayan, P.M., Stegemann, J.P. Collagen-carbon nanotube composite materials as scaffolds in tissue engineering. J. Biomed. Mater. Res. Part A, 2005, 74A(3), 489-496.
30. Spitalsky, Z., Tasis, D., Papagelis, K., Galiotis, C. Carbon nanotube polymer composites: Chemistry, processing, mechanical and electrical properties. Prog. Polym. Sci., 2010, 35(3), 357-401.
31. Zanello, L.P., Zhao, B., Hu, H., Haddon, R.C. Bone cell proliferation on carbon nanotubes. Nano Lett., 2006, 6(3), 562-567.
32. ASTM, ASTM D638-98. Annual Book of ASTM Standards. 1982, Vol. 8.2, p. 45.
33. Nakao, H., Hyon, S.H., Tsutsumi, S., Matsumoto, T., Takahashi, J. Control pore size in L-lactide/ -caprolactone copolymer foam for tissue regeneration by the Freeze-drying method. Dent. Mater. J., 2003, 22(3), 262-271.
34. Wan, Y., Fang, Y., Wu, H., Cao, X. Porous polylactide/chitosan scaffolds for tissue engineering. J. Biomed. Mater. Res. A, 2007, 80A(4), 776-789.
35. Wan, Y., Yu, A., Wu, H., Wang, Z., Wen, D. Porous-conductive chitosan scaffolds for tissue engineering II. in vitro and in vivo degradation. J. Mater. Sci. Mater. Med., 2005, 16(11), 1017-1028.
36. Liao, K., Li, S. Interfacial characteristics of a carbon nanotube-polystyrene composite system. Appl. Phys. Lett., 2001, 79, 4225.
37. Rotter, N., Bücheler, M., Haisch, A., Wollenberg, B., Lang, S. Cartilage tissue engineering using resorbable scaffolds. J. Tissue Eng. Regen. Med., 2007,1(6), 411-416.
38. Li, X., Feng, Q. Porous poly-L-lactic acid scaffold reinforced by chitin fibers. Polym. Bull. (Berlin), 2005, 54(1), 47-55.
39. Hong, Z., Qiu, X., Sun, J., Deng, M., Chen, X., Jing, X. Grafting polymerization of L-lactide on the surface of hydroxyapatite nano-crystals. Polymer, 2004, 45(19), 6699-6706.
40. Yoon, J.T., Lee, S.C., Jeong, Y.G. Effects of grafted chain length on mechanical and electrical properties of nanocomposites containing polylactide-grafted carbon nanotubes. Compos. Sci. Technol., 2010, 70(5), 776-782.
41. Lee, H.B., Khang, G., Lee, G.H. Polymeric Biomaterials, Park, J.B., Bronzino, J. D., Eds., In: Biomaterials: Principles and applications, CRC press: Boca Raton, FL, 2003, pp. 55-78.
42. Lu, Y.L., Cheng, C.M., LeDuc, P.R., Ho, M.H. Controlling the mechanics and nanotopography of biocompatible scaffolds through dielectrophoresis with carbon nanotubes. Electrophoresis, 2008, 29(15), 3123-3127.
43. Hutmacher, D.W. Scaffolds in tissue engineering bone and cartilage. Biomaterials, 2000, 21(24), 2529-2543.
44. Ozmusul, M.S., Picu, R.C. Structure of polymers in the vicinity of convex impenetrable surfaces: the athermal case. Polymer, 2002, 43(17), 4657-4665.
45. Chen, G., Okamura, A., Sugiyama, K., Wozniak, M.J., Kawazoe, N., Sato, S., Tateishi, T. Surface modification of porous scaffolds with nanothick collagen layer by centrifugation and freeze-drying. J. Biomed. Mater. Res. Part B: Appl. Biomater., 2009, 90B(2), 864-872.
46. Vert, M., Mauduit, J., Li, S. Biodegradation of PLA/GA polymers: increasing complexity. Biomaterials, 1994, 15(15), 1209-1213.
47. Yuan, X., Mak, A.F.T., Yao, K. In vitro degradation of poly(L- lactic acid) fibers in phosphate buffered saline. J. Appl. Polym. Sci., 2002, 85(5), 936-943.
48. Yuan, X., Mak, A.F.T., Yao, K. Comparative observation of accelerated degradation of poly(-lactic acid) fibres in phosphate buffered saline and a dilute alkaline solution. Polym. Degrad. Stab., 2002, 75(1), 45-53.
49. de Jong, S.J., Arias, E.R., Rijkers, D.T.S., van Nostrum, C.F., Kettenes-van den Bosch, J.J., Hennink, W.E. New insights into the hydrolytic degradation of poly(lactic acid): participation of the alcohol terminus. Polymer, 2001, 42(7), 2795-2802.
50. Kawai, F., Schink, B. The biochemistry of degradation of polyethers. Crit. Rev. Biotechnol., 1987, 6(3), 273-307.
51. Tsuji, H., Doi, Y., Steinbüchel, A. Biopolymers: Polyesters III application and commercial products, Wiley-VCH: Weinheim, 2002, Vol. 4, pp. 129-177.
52. Holy, C.E., Dang, S.M., Davies, J.E., Shoichet, M.S. In vitro degradation of a novel poly(lactide-co-glycolide) 75/25 foam. Biomaterials, 1999, 20(13), 1177-1185.