Expression level of glutamine synthetase is increased in hepatocellular carcinoma and liver tissue with cirrhosis and chronic hepatitis B

Hepatology International

Volumn 5, Issue 2, 2011, Pages 698-706

  Long, Jiang ^a,b   Wang, Huaguang ^c   Lang, Zhenwei ^b   Wang, Tailing ^d   Long, Mei ^e   Wang, Baoen ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^e MUDANJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Chronic hepatitis B; Glutamine synthetase; Hepatocellular carcinoma; Liver cirrhosis; Receiver operating characteristic curve; Regeneration; Sensitivity and specificity

Indexed keywords

ALPHA FETOPROTEIN; GLUTAMATE AMMONIA LIGASE;

ADULT; ARTICLE; CANCER STAGING; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE MARKER; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY;

EID: 79956271700     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-010-9230-2     Document Type: Article

References (27)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108 (PubMed: 15761078) (Pubitemid 40372904)
2. Seow TK, Liang RC, Leow CK, Chung MC. Hepatocellular carcinoma: from bedside to proteomics. Proteomics 2001;1:1249-1263 (PubMed: 11721636)
3. Zhou XD, Tang ZY, Yang BH, Lin ZY, Ma ZC, Ye SL, Wu ZQ, Fan J, Qin LX, Zheng BH. Experience of 1000 patients who underwent hepateetomy for BlnaU hepatoeellular carcinoma. Cancer 2001;91:1479-1486 (PubMed: 11301395) (Pubitemid 32319258)
4. Bioulac-Sage P, Laumonier H, Rullier A, Cubel G, Laurent C, Zucman-Rossi J, Balabaud C. Over-expression of glutamine synthetase in focal nodular regeneration: a novel easy diagnostic tool in surgical pathology. Liver Int 2009;29:459-465 (PubMed: 18803590)
5. Brosnan ME, Brosnan JT. Hepatic glutamate metabolism: a tale of 2 hepatocytes. Am J Clin Nutr 2009;90:857-861 (PubMed: 19625684)
6. Gebhardt R, Alicja BF, Krügel V, Ueberham E, Gaunitz F. Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. Prog Histochem Cytochem 2007;41:201-266 (PubMed: 17368308) (Pubitemid 46412421)
7. Christa L, Simon MT, Flinois JP, Gebhardt R, Brechot C, Lasserre C. Overexpression of glutamine synthetase in human primary liver cancer. Gastroenterology 1994;106:1312-1320 (PubMed: 7909780) (Pubitemid 24129249)
8. Kuo CF, Paulson KE, Darnell JE Jr. Positional and developmental regulation of glutamine synthetase expression in mouse liver. Mol Cell Biol 1988;8:4966-4971 (PubMed: 2905422) (Pubitemid 18261569)
9. Di Tommaso L, Destro A, Seok JY, Balladore E, Terracciano L, Sangiovanni A, Iavarone M, Colombo M, Jang JJ, Yu E, Jin SY, Morenghi E, Park YN, Roncalli M. The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma. J Hepatol 2009;50:746-754 (PubMed: 19231003)
10. Oka H, Tamori A, Kuroki T, Kobayashi K, Yamamoto S. Prospective study of alpha-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma. Hepatology 1994;19:61-66 (PubMed: 7506227)
11. Häussinger D, Schliess F. Glutamine metabolism and signaling in the liver. Front Biosci 2007;12:371-391 (PubMed: 17127305)
12. Poyck PP, Hoekstra R, Vermeulen JL, van Wijk AC, Chamuleau RA, Hakvoort TB, van Gulik TM, Lamers WH. Expression of glutamine synthetase and carbamoylphosphate synthetase in a bioartificial liver: markers for the development of zonation in vitro. Cells Tissues Organs 2008;188:259-269 (PubMed: 18354250)
13. Malarkey DE, Johnson K, Ryan L, Boorman G, Maronpot RR. New insights into functional aspects of liver morphology. Toxicol Pathol 2005;33:27-34 (PubMed: 15805053) (Pubitemid 40216801)
14. Fung J, Lai CL, Yuen MF. Hepatitis B and C virus-related carcinogenesis. Clin Microbiol Infect 2009;15:964-970 (PubMed: 19874379)
15. Medina MA. Glutamine and cancer. J Nutr 2001;131:2539-2542 (PubMed: 11533309)
16. Yang C, Sudderth J, Dang T, Bachoo RG, McDonald JG, DeBerardinis RJ. Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res 2009;69:7986-7993 (PubMed: 19826036)
17. Dang CV. MYC, microRNAs and glutamine addiction in cancers. Cell Cycle 2009;8:3243-3245 (PubMed: 19806017)
18. DeBerardinis RJ, Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010;29:313-324 (PubMed: 19881548)
19. Cadoret A, Ovejero C, Terris B, Souil E, Lévy L, Lamers WH, Kitajewski J, Kahn A, Perret C. New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene 2002;21:8293-8301 (PubMed: 12447692) (Pubitemid 35477869)
20. Cieply B, Zeng G, Proverbs-Singh T, Geller DA, Monga SP. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Hepatology 2009;49:821-831 (PubMed: 19101982)
21. Behari J, Zeng G, Otruba W, Thompson MD, Muller P, Micsenyi A, Sekhon SS, Leoni L, Monga SP. R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells. J Hepatol 2007;46:849-857 (PubMed: 17275129) (Pubitemid 46529036)
22. Di Tommaso L, Franchi G, Park YN, Fiamengo B, Destro A, Morenghi E, Montorsi M, Torzilli G, Tommasini M, Terracciano L, Tornillo L, Vecchione R, Roncalli M. Diagnostic value of HSP70, Glypican 3, and Glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 2007;45:725-734 (PubMed: 17326147) (Pubitemid 46450624)
23. Niva CC, Lee JM, Myohara M. Glutamine synthetase gene expression during the regeneration of the annelid Enchytraeus japonensis. Dev Genes Evol 2008;218:39-46. (PubMed: 18183418)
24. Apte U, Singh S, Zeng G, Cieply B, Virji MA, Wu T. Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury. Am J Pathol 2009;175:1056-1065 (PubMed: 19679878)
25. Sekine S, Gutierrez PJ, Lan BY, Feng S, Hebrok M. Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. Hepatology 2007;45:361-368 (PubMed: 17256747) (Pubitemid 46374592)
26. Tan X, Behari J, Cieply B, Michalopoulos GK, Monga SP. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 2006;131:1561-1572 (PubMed: 17101329) (Pubitemid 44708943)
27. Schmidt LE, Dalhoff K. Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury. Hepatology 2005;41:26-31 (PubMed: 15690478) (Pubitemid 40066379)