The impact of circulating cholesterol crystals on vasomotor function: Implications for no-reflow phenomenon

JACC: Cardiovascular Interventions

Volumn 4, Issue 5, 2011, Pages 521-529

  Gadeela, Nitesh ^a   Rubinstein, Jack ^a,c   Tamhane, Umesh ^a   Huang, Ruiping ^a   Pathak, Dorothy R ^a   Hosein, Hazel Ann ^b   Rich, Michael ^b   Dhar, Gaurav ^a   Abela, George S ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

cholesterol crystals; no reflow; plaque rupture; vasoreactivity

Indexed keywords

ACETYLCHOLINE; CHOLESTEROL; MICROSPHERE; NITROPRUSSIDE SODIUM; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DIAMETER; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTERY INTIMA; ARTICLE; ATOMIC FORCE MICROSCOPY; BLOOD VESSEL FUNCTION; CAROTID ARTERY FLOW; CONTROLLED STUDY; CRYSTAL; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; EXPERIMENTAL RABBIT; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY;

ACETYLCHOLINE; ANIMALS; CAROTID ARTERY INJURIES; CHOLESTEROL; CRYSTALLIZATION; ENDOTHELIUM, VASCULAR; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; NITROPRUSSIDE; NO-REFLOW PHENOMENON; NOREPINEPHRINE; RABBITS; VASCULAR SYSTEM INJURIES; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 79956257779     PISSN: 19368798     EISSN: 18767605     Source Type: Journal    
DOI: 10.1016/j.jcin.2011.02.010     Document Type: Article

References (37)

1. Constantinides P. Plaque fissures in human coronary thrombosis. J Atheroscler Res 1966;6:1-17.
2. Davies MJ, Thomas AC. Plaque fissuring: the cause of acute myocardial infarction causing sudden ischaemic death, and crescendo angina. Br Heart J 1985;53:363-73. (Pubitemid 15055510)
3. Schaar JA, Muller JE, Falk E, et al. Terminology for high-risk and vulnerable coronary artery plaques. Report of a meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece. Eur Heart J 2004;25:1077-82. (Pubitemid 38869428)
4. Falk E, Thuesen L. Pathology of coronary microembolisation and no reflow. Heart 2003;89:983-5. (Pubitemid 37046823)
5. Reffelmann T, Kloner RA. The "no-reflow" phenomenon: basic science and clinical correlates. Heart 2002;87:162-8.
6. Scolari F, Tardanico R, Zani R, et al. Cholesterol crystal embolism: a recognizable cause of renal disease. Am J Kidney Dis 2000;36:1089-109.
7. Rupprecht H. [Postinterventional cholesterol crystal embolization]. Dtsch Med Wochenschr 2007;132:1833-6.
8. Kotani J, Nanto S, Mintz GS, et al. Plaque gruel of atheromatous coronary lesion may contribute to the no-reflow phenomenon in patients with acute coronary syndrome. Circulation 2002;106:1672-7.
9. Breuckmann F, Nassenstein K, Bucher C, et al. Systematic analysis of functional and structural changes after coronary microembolization: a cardiac magnetic resonance imaging study. J Am Coll Cardiol Img 2009;2:121-30.
10. Romagnoli E, Lanza GA. Acute myocardial infarction with normal coronary arteries: role of coronary artery spasm and arrhythmic complications. Int J Cardiol 2007;117:3-5. (Pubitemid 46399993)
11. Uren NG, Crake T, Lefroy DC, de Silva R, Davies GJ, Maseri A. Reduced coronary vasodilator function in infarcted and normal myocardium after myocardial infarction. N Engl J Med 1994;331:222-7. (Pubitemid 24226679)
12. Fischell TA, Subraya RG, Ashraf K, Perry B, Haller S. "Pharmacologic" distal protection using prophylactic, intragraft nicardipine to prevent no-reflow and non-Q-wave MI during elective saphenous vein graft intervention. J Invasive Cardiol 2007;19:58-62.
13. Rezkalla SH, Kloner RA. No-reflow phenomenon. Circulation 2002;105:656-62. (Pubitemid 34123444)
14. Abela GS, Aziz K, Vedre A, Pathak DR, Talbott JD, Dejong J. Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes. Am J Cardiol 2009;103:959-68.
15. Abela GS, Shamoun F, Vedre A, et al. Extent of cholesterol crystals in coronary artery aspirates during acute myocardial infarction (abstr). J Am Coll Cardiol 2010;55 Suppl A:109.
16. Schwartz RS, Burke A, Farb A, et al. Microemboli and microvascular obstruction in acute coronary thrombosis and sudden coronary death: relation to epicardial plaque histopathology. J Am Coll Cardiol 2009;54:2167-73.
17. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 1992;326:310-8.
18. Hackett D, Davies G, Chierchia S, Maseri A. Intermittent coronary occlusion in acute myocardial infarction. Value of combined thrombolytic and vasodilator therapy. N Engl J Med 1987;317:1055-9. (Pubitemid 17146897)
19. Furchgott RF. The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide. JAMA 1996;276:1186-8.
20. Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315:1046-51. (Pubitemid 17170620)
21. Prieto AR, Ma H, Huang R, et al. Thrombostatin, a bradykinin metabolite, reduces platelet activation in a model of arterial wall injury. Cardiovasc Res 2002;53:984-92. (Pubitemid 34261036)
22. Elizabeth A, Joseph C, Ittyachen MA. Growth and microtopographical studies of gel grown cholesterol crystals. Bull Matters Sci 2001;24:431-4. (Pubitemid 32748768)
23. Abela GS, Aziz K. Cholesterol crystals rupture biological membranes and human plaques during acute cardiovascular events: a novel insight into plaque rupture by scanning electron microscopy. Scanning 2006;28:1-10. (Pubitemid 43221678)
24. Vedre A, Pathak DR, Crimp M, Lum C, Koochesfahani M, Abela GS. Physical factors that trigger cholesterol crystallization leading to plaque rupture. Atherosclerosis 2009;203:89-96.
25. Abela GS. Cholesterol crystals piercing the arterial plaque and intima triggers local and systemic inflammation. J Clin Lipidol 2010;4:156-64.
26. Düewell P, Kono H, Rayner KJ, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010;464:1357-61.
27. Nair PN, Sjögren U, Sundqvist G. Cholesterol crystals as an etiological factor in on-resolving chronic inflammation: an experimental study in guinea pigs. Eur J Oral Sci 1998;106:644-50. (Pubitemid 128737070)
28. Pervaiz MH, Huang R, Narisetty K, Vedre A, Berger K, Abela GS. Effects of showering of cholesterol crystals on muscle injury (abstr). Ather Thromb Vasc Biol 2010;30:e257,P395.
29. Halcox JP, Schenke WH, Zalos G, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002;106:653-8. (Pubitemid 34851922)
30. Hollenshorst RW. Vascular status of patients who have cholesterol emboli in the retina. Am J Ophthalmol 1966;61:1159-65.
31. Fukumoto Y, Tsutsui H, Tsuchihashi M, et al., for the CHEST Investigators. The incidence and risk factors of cholesterol embolization syndrome, a complication of cardiac catheterization: a prospective study. J Am Coll Cardiol 2003;42:211-6. (Pubitemid 36851407)
32. Falanga V, Fine MJ, Kapoor WN. The cutaneous manifestations of cholesterol crystal embolization. Arch Dermatol 1986;122:1194-8. (Pubitemid 16022288)
33. Mehta RH, Harjai KJ, Cox D, et al., for the PAMI Investigators. Clinical and angiographic correlates and outcomes of suboptimal coronary flow in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. J Am Coll Cardiol 2003;42:1739-46. (Pubitemid 37433651)
34. Ross AM, Gibbons RJ, Stone GW, et al., for the AMISTAD-II Investigators. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol 2005;45:1775-80. (Pubitemid 40779856)
35. Vedre A, Aziz K, Huang R, Abela GS. Aspirin prevents cholesterol crystallization: a potential mechanism of plaque stabilization. J Am Coll Cardiol 2008;51 Suppl A:318.
36. Abela GS, Vedre A, Janoudi A, Huang R, Durga S, Tamhane U. Effect of statins on cholesterol crystallization and atherosclerotic plaque stabilization. Am J Cardiol 2011 Apr 18 [E-pub ahead of print]; doi: 10.1016/j.amjcard.2011. 02.336.
37. Adams CW, Abdulla YH. The action of human high density lipoprotein on cholesterol crystals. Atherosclerosis 1978;31:465-71.