Involvement of Matrix Metalloproteinase-2 in the Development of Medial Layer Vascular Calcification in Uremic Rats

Therapeutic Apheresis and Dialysis

Volumn 15, Issue SUPPL.1, 2011, Pages 18-22

  Kumata, Chiaki ^a   Mizobuchi, Masahide ^a   Ogata, Hiroaki ^b   Koiwa, Fumihiko ^c   Kondo, Fumiko ^a   Kinugasa, Eriko ^b   Akizawa, Tadao ^a  

^a SHOWA UNIVERSITY   (Japan)

^b SHOWA UNIVERSITY NORTHERN YOKOHAMA HOSPITAL   (Japan)

^c SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Chronic kidney disease; Elastin degradation; Matrix metalloproteinase 2; Vascular calcification

Indexed keywords

ELASTIN; GELATINASE A; LACTIC ACID; PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA MEDIA; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL CALCIFICATION; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIETARY INTAKE; MALE; NEPHRECTOMY; NONHUMAN; OSTEOBLAST; PARATHYROID HORMONE BLOOD LEVEL; PATHOPHYSIOLOGY; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; UREMIA; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; BLOOD PRESSURE; CALCINOSIS; CARDIOVASCULAR DISEASES; CHRONIC DISEASE; CREATININE; ELASTIN; KIDNEY DISEASES; MALE; MATRIX METALLOPROTEINASE 2; PARATHYROID HORMONE; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; UREMIA;

EID: 79956221359     PISSN: 17449979     EISSN: 17449987     Source Type: Journal    
DOI: 10.1111/j.1744-9987.2011.00921.x     Document Type: Article

References (15)

1. London GM, Guerin AP, Marchais SJ, Metivier F, Pannier B, Adda H. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 2003;18:1731-40.
2. Mizobuchi M, Towler D, Slatopolsky E. Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol 2009;20:1453-64.
3. Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res 2006;99:1044-59.
4. Pecovnik-Balon B. Cardiovascular calcification in patients with end-stage renal disease. Ther Apher Dial 2005;9:208-10.
5. Derici U, El Nahas AM. Vascular calcifications in uremia: old concepts and new insights. Semin Dial 2006;19:60-8.
6. Pai AS, Giachelli CM. Matrix remodeling in vascular calcification associated with chronic kidney disease. J Am Soc Nephrol 2010;21:1637-40.
7. Antonicelli F, Bellon G, Debelle L, Hornebeck W. Elastin-elastases and inflamm-aging. Curr Top Dev Biol 2007;79:99-155.
8. Simionescu A, Philips K, Vyavahare N. Elastin-derived peptides and TGF-beta1 induce osteogenic responses in smooth muscle cells. Biochem Biophys Res Commun 2005;334:524-32.
9. Aikawa E, Aikawa M, Libby P etal. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation 2009;119:1785-94.
10. Basalyga DM, Simionescu DT, Xiong W, Baxter BT, Starcher BC, Vyavahare NR. Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases. Circulation 2004;110:3480-7.
11. Murshed M, McKee MD. Molecular determinants of extracellular matrix mineralization in bone and blood vessels. Curr Opin Nephrol Hypertens 2010;19:359-65.
12. Hosaka N, Mizobuchi M, Ogata H etal. Elastin degradation accelerates phosphate-induced mineralization of vascular smooth muscle cells. Calcif Tissue Int 2009;85:523-9.
13. Chung AW, Yang HH, Kim JM etal. Upregulation of matrix metalloproteinase-2 in the arterial vasculature contributes to stiffening and vasomotor dysfunction in patients with chronic kidney disease. Circulation 2009;120:792-801.
14. Lee JS, Basalyga DM, Simionescu A, Isenburg JC, Simionescu DT, Vyavahare NR. Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses. Am J Pathol 2006;168:490-8.
15. Qin X, Corriere MA, Matrisian LM, Guzman RJ. Matrix metalloproteinase inhibition attenuates aortic calcification. Arterioscler Thromb Vasc Biol 2006;26:1510-16.