Activation of picornaviral IRESs by PTB shows differential dependence on each PTB RNA-binding domain

RNA

Volumn 17, Issue 6, 2011, Pages 1120-1131

  Kafasla, Panagiota ^a   Lin, Helen ^a   Curry, Stephen ^b   Jackson, Richard J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Encephalomyocarditis virus; IRES; Poliovirus; RBD (RNA binding domain); RRM (RNA recognition motif); Tethered hydroxyl radical probing

Indexed keywords

POLYPYRIMIDINE TRACT BINDING PROTEIN;

ARTICLE; ENCEPHALOMYOCARDITIS VIRUS; INTERNAL RIBOSOME ENTRY SITE; NONHUMAN; NUCLEOTIDE BINDING SITE; PICORNAVIRUS; POINT MUTATION; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; RNA BINDING; VIRUS ACTIVATION;

BINDING SITES; ENCEPHALOMYOCARDITIS VIRUS; NUCLEIC ACID CONFORMATION; PICORNAVIRIDAE; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; RIBOSOMES; RNA, VIRAL;

ENCEPHALOMYOCARDITIS VIRUS; PICORNAVIRIDAE; POLIOVIRUS;

EID: 79956202149     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2549411     Document Type: Article

References (24)

1. Alexander L, Lu HH, Wimmer E. 1994. Polioviruses containing picornavirus type 1 and/or type 2 internal ribosomal entry site elements: Genetic hybrids and the expression of a foreign gene. Proc Natl Acad Sci 91: 1406-1410. (Pubitemid 24059020)
2. Auweter SD, Allain FHT. 2008. Structure-function relationships of the polypyrimidine tract binding protein. Cell Mol Life Sci 65: 516-527.
3. Back SH, Kim YK, Kim WJ, Cho S, Oh HR, Kim JE, Jang SK. 2002. Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3C(pro). J Virol 76: 2529-2542. (Pubitemid 34150721)
4. Das R, Laederach A, Pearlman SM, Herschlag D, Altman RB. 2005. SAFA: Semi-automated footprinting analysis software for high-throughput quantification of nucleic acid footprinting experiments. RNA 11: 344-354. (Pubitemid 40270826)
5. de Breyne S, Yu Y, Unbehaun A, Pestova TV, Hellen CU. 2009. Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites. Proc Natl Acad Sci 106: 9197-9202.
6. Duke GM, Hoffman MA, Palmenberg AC. 1992. Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation. J Virol 66: 1602-1609.
7. Ghetti A, Pinol-Roma S, Michael WM, Morandi C, Dreyfuss G. 1992. hnRNP-I, the polypyrimidine tract-binding protein: Distinct nuclear localization and association with hnRNAs. Nucleic Acids Res 20: 3671-3678.
8. Hunt SL, Jackson RJ. 1999. Polypyrimidine-tract binding protein (PTB) is necessary, but not sufficient, for efficient internal initiation of translation of human rhinovirus-2 RNA. RNA 5: 344-359. (Pubitemid 29124995)
9. Jackson RJ, Kaminski A. 1995. Internal initiation of translation in eukaryotes: The picornavirus paradigm and beyond. RNA 1: 985-1000.
10. Jang SK, Wimmer E. 1990. Cap-independent translation of encephalomyocarditis virus RNA: Structural elements of the internal ribosome entry site and involvement of a cellular 57-kDa RNAbinding protein. Genes Dev 4: 1560-1572.
11. Kafasla P, Morgner N, Pöyry TA, Curry S, Robinson CV, Jackson RJ. 2009. Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation. Mol Cell 34: 556-568.
12. Kafasla P, Morgner N, Robinson CV, Jackson RJ. 2010. Polypyrimidine tract binding protein stimulates the poliovirus IRES by modulating eIF4G binding. EMBO J 29: 3710-3722.
13. Kaminski A, Jackson RJ. 1998. The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute. RNA 4: 626-638. (Pubitemid 28252745)
14. Kaminski A, Hunt SL, Patton JG, Jackson RJ. 1995. Direct evidence that polypyrimidine tract binding protein (PTB) is essential for internal initiation of translation of encephalomyocarditis virus RNA. RNA 1: 924-938.
15. Laederach A, Das R, Vicens Q, Pearlman SM, Brenowitz M, Herschlag D, Altman RB. 2008. Semi-automated and rapid quantification of nucleic acid footprinting and structure mapping experiments. Nat Protoc 3: 1395-1401.
16. Monie TP, Hernandez H, Robinson CV, Simpson P, Matthews S, Curry S. 2005. The polypyrimidine tract binding protein is a monomer. RNA 11: 1803-1808. (Pubitemid 41720030)
17. Niepmann M. 1996. Porcine polypyrimidine tract-binding protein stimulates translation initiation at the internal ribosome entry site of foot-and-mouth-disease virus. FEBS Lett 388: 39-42. (Pubitemid 26181170)
18. Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, et al. 2005. Structure of PTB bound to RNA: Specific binding and implications for splicing regulation. Science 309: 2054-2057. (Pubitemid 41362323)
19. Pilipenko EV, Pestova TV, Kolupaeva VG, Khitrina EV, Poperechnaya AN, Agol VI, Hellen CU. 2000. A cell cycle-dependent protein serves as a template-specific translation initiation factor. Genes Dev 14: 2028-2045. (Pubitemid 30637353)
20. Sawicka K, Bushell M, Spriggs KA, Willis AE. 2008. Polypyrimidinetract- binding protein: A multifunctional RNA-binding protein. Biochem Soc Trans 36: 641-647.
21. Simpson PJ, Monie TP, Szendroi A, Davydova N, Tyzack JK, Conte MR, Read CM, Cary PD, Svergun DI, Konarev PV, et al. 2004. Structure and RNA interactions of the N-Terminal RRM domains of PTB. Structure 12: 1631-1643. (Pubitemid 39200516)
22. Song Y, Tzima E, Ochs K, Bassili G, Trusheim H, Linder M, Preissner KT, Niepmann M. 2005. Evidence for an RNA chaperone function of polypyrimidine tract-binding protein in picornavirus translation. RNA 11: 1809-1824. (Pubitemid 41720031)
23. Spellman R, Rideau A, Matlin A, Gooding C, Robinson F, McGlincy N, Grellscheid SN, Southby J, Wollerton M, Smith CW. 2005. Regulation of alternative splicing by PTB and associated factors. Biochem Soc Trans 33: 457-460. (Pubitemid 40873864)
24. Wollerton MC, Gooding C, Robinson F, Brown EC, Jackson RJ, Smith CW. 2001. Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB). RNA 7: 819-832. (Pubitemid 32552870)