Polyamine Analysis by LC-MS

Methods in Molecular Biology

Volumn 720, Issue , 2011, Pages 505-518

  Häkkinen, Merja R ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

LC MS MS; Method development; Polyamine analogs; Polyamines; Selected reaction monitoring; Validation

Indexed keywords

POLYAMINE;

ARTICLE; CHEMISTRY; CHROMATOGRAPHY; FLOW INJECTION ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; REPRODUCIBILITY; SOLUTION AND SOLUBILITY; STANDARD;

CHROMATOGRAPHY; CHROMATOGRAPHY, LIQUID; FLOW INJECTION ANALYSIS; MASS SPECTROMETRY; POLYAMINES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLUTIONS;

EID: 79956195777     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61779-034-8_33     Document Type: Chapter

References (24)

1. Teti D, Visalli M, McNair H (2002) Analysis of polyamines as markers of (patho)physiologi-cal conditions. J Chromatogr B 781:107–149
2. Kostiainen R, Kotiaho T, Kuuranne T, Auriola S (2003) Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies. J Mass Spectrom 38: 357–372
3. Politi L, Groppi A, Polettini A (2006) Ionization, ion separation and ion detection in LC-MS. In: Polettini A (ed) Applications of LC-MS in toxicology. Pharmaceutical Press, London, pp 1–22
4. Glish GL, Vachet RW (2003) The basics of mass spectrometry in the twenty-first century. Nat Rev Drug Discov 2:140–150
5. Principles of MS Quantitation (2009) Available at: http://www.ionsource.com/tutorial/msquan/requantoc.htm/
6. Holčapek M, Kolarová L, Nobilis M (2008) High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites. Anal Bioanal Chem 391:59–78
7. Capote FP, Jiménez RJ, Granados JM, de Castro MDL (2007) Identification and determination of fat-soluble vitamins and metabolites in human serum by liquid chromatography/ triple quadrupole mass spectrometry with multiple reaction monitoring. Rapid Commun Mass Spectrom 21:1745–1754
8. Feistner GJ (1994) Metabolites of Erwinia 9. Profiling of basic-amino-acids and polyamines in microbial culture supernatants by electrospray mass-spectrometry. Biol Mass Spectrom 23:784–792
9. Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S (2007) Analysis of underivatized polyamines by reversed phase liquid chromatography with electrospray tandem mass spectrometry. J Pharm Biomed Anal 45:625–634
10. Cecchi T (2008) Ion pairing chromatography. Crit Rev Anal Chem 38:161–213
11. Khuhawar MY, Qureshi GA (2001) Polyamines as cancer markers: applicable separation methods. J Chromatogr B 764:385–407
12. Kostiainen R, Kauppila TJ (2009) Effect of eluent on the ionization process in liquid chromatography-mass spectrometry. J Chromatogr A 1216:685–699
13. Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S (2008) Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS. J Pharm Biomed Anal 48:414–421
14. Kuhlmann FE, Apffel A, Fischer SM, Goldberg G, Goodley PC (1995) Signal enhancement for gradient reverse-phase high-performance liquid chromatography electrospray ionization mass spectrometry analysis with trifluoroacetic and other strong acid modifiers by postcol-umn addition of propionic acid and isopropa-nol. J Am Soc Mass Spectrom 6:1221–1225
15. Apffel A, Fischer S, Goldberg G, Goodley PC, Kuhlmann FE (1995) Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases. J Chromatogr A 712:177–190
16. Shou WZ, Naidong W (2005) Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography-electrospray tandem mass spectrometric (HILIC-ESI/ MS/MS) bioanalysis of basic compounds. J Chromatogr B 825:186–192
17. Taylor PJ (2005) Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin Biochem 38:328–334
18. Bonfiglio R, King RC, Olah TV, Merkle K (1999) The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commun Mass Spectrom 13:1175–1185
19. Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 75:3019–3030
20. Eeckhaut AV, Lanckmans K, Sarre S, Smolders I, Michotte Y (2009) Validation of bioanalytical LC–MS/MS assays: evaluation of matrix effects. J Chromatogr B 877:2198–2207
21. Taylor PJ (2006) Method development and optimisation of LC-MS. In: Polettini A (ed) Applications of LC-MS in toxicology. Pharmaceutical Press, London, pp 23–42
22. Kronstrand R, Josefsson M (2006) Quantification using LC-MS. In: Polettini A (ed) Applications of LC-MS in toxicology. Pharmaceutical Press, London, pp 43–70
23. US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER) (2001) Guidance for industry, bioanalytical method validation. Available at: http://www. fda.gov/cder/guidance/4252fnl.pdf
24. Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J (2009) Synthesis of novel deuterium labeled derivatives of N-alkylated polyamines. Tetrahedron 65:547–562