Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma

Inflammation

Volumn 34, Issue 3, 2011, Pages 193-197

  Hayakawa, Mineji ^a   Katabami, Kenichi ^a   Wada, Takeshi ^a   Minami, Yousuke ^a   Sugano, Masahiro ^a   Shimojima, Hidekazu ^a   Kubota, Nobuhiko ^a   Uegaki, Shinji ^a   Sawamura, Atsushi ^a   Gando, Satoshi ^a  

^a HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

glucocorticoids; multiple organ failure; multiple trauma; systemic inflammatory response syndrome; tumor necrosis factor alpha

Indexed keywords

HYDROCORTISONE; MACROPHAGE MIGRATION INHIBITION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLUNT TRAUMA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; MACROPHAGE MIGRATION INHIBITION FACTOR BLOOD LEVEL; MALE; MULTIPLE ORGAN FAILURE; PREDICTIVE VALUE; PROTEIN BLOOD LEVEL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; SYSTOLIC BLOOD PRESSURE; TUMOR NECROSIS FACTOR ALPHA BLOOD LEVEL;

ADULT; FEMALE; HEAD INJURIES, CLOSED; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFLAMMATION MEDIATORS; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PITUITARY-ADRENAL SYSTEM; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WOUNDS, NONPENETRATING; YOUNG ADULT;

EID: 79956160494     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-010-9223-2     Document Type: Article

References (26)

1. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. 1992. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Critical Care Medicine 20: 864-874.
2. Malone, D.L., D. Kuhls, L.M. Napolitano, R. McCarter, and T. Scalea. 2001. Back to basics: Validation of the admission systemic inflammatory response syndrome score in predicting outcome in trauma. Journal of Trauma 51: 458-463. (Pubitemid 33009628)
3. Nast-Kolb, D., M. Aufmkolk, S. Rucholtz, U. Obertacke, and C. Waydhas. 2001. Multiple organ failure still a major cause of morbidity but not mortality in blunt multiple trauma. Journal of Trauma 51: 835-841.
4. Napolitano, L.M., T. Ferrer, R.J. McCarter Jr., and T.M. Scalea. 2000. Systemic inflammatory response syndrome score at admission independently predicts mortality and length of stay in trauma patients. Journal of Trauma 49: 647-652.
5. Bochicchio, G.V., L.M. Napolitano, M. Joshi, R.J. McCarter Jr., and T.M. Scalea. 2001. Systemic inflammatory response syndrome score at admission independently predicts infection in blunt trauma patients. Journal of Trauma 50: 817-820. (Pubitemid 32499604)
6. Rhen, T., and J.A. Cidlowski. 2005. Antiinflammatory action of glucocorticoids - New mechanisms for old drugs. New England Journal of Medicine 353: 1711-1723.
7. Baue, A.E. 2006. MOF, MODS, and SIRS: What is in a name or an acronym? Shock 26: 438-449.
8. Bloom, B.R., and B. Bennett. 1966. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science 153: 80-82.
9. Calandra, T., J. Bernhagen, C.N. Metz, L.A. Spiegel, M. Bacher, T. Donnelly, A. Cerami, and R. Bucala. 1995. MIF as a glucocorticoidinduced modulator of cytokine production. Nature 377: 68-71.
10. Flaster, H., J. Bernhagen, T. Calandra, and R. Bucala. 2007. The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Molecular Endocrinology 21: 1267-1280. (Pubitemid 46984737)
11. Gando, S., J. Nishihira, S. Kobayashi, Y. Morimoto, S. Nanzaki, and O. Kemmotsu. 2001. Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome. Intensive Care Medicine 27: 1187-1193. (Pubitemid 32710206)
12. Gando, S., A. Sawamura, M. Hayakawa, H. Hoshino, N. Kubota, and J. Nishihira. 2007. High macrophage migration inhibitory factor levels in disseminated intravascular coagulation patients with systemic inflammation. Inflammation 30: 118-124. (Pubitemid 46985776)
13. Chuang, C.C., C.J. Hung, M.C. Tsai, T.M. Yeh, and Y.C. Chuang. 2004. High concentrations of circulating macrophage migration inhibitory factor in patients with severe blunt trauma: Is serum macrophage migration inhibitory factor concentration a valuable prognostic factor? Critical Care Medicine 32: 734-739.
14. Baker, S.P., B. O'Neill, W. Haddon Jr., and W.B. Long. 1974. The injury severity score: A method for describing patients with multiple injuries and evaluating emergency care. Journal of Trauma 14: 187-196.
15. Vincent, J.L., A. de Mendonca, F. Cantraine, R. Moreno, J. Takala, P. M. Suter, C.L. Sprung, F. Colardyn, and S. Blecher. 1998. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Critical Care Medicine 26: 1793-1800.
16. Knaus, W.A., E.A. Draper, D.P. Wagner, and J.E. Zimmerman. 1985. APACHE II: A severity of disease classification system. Critical Care Medicine 13: 818-829. (Pubitemid 15250137)
17. Nishihira, J., Y. Koyama, and Y. Mizue. 1998. Identification of macrophage migration inhibitory factor (MIF) in human vascular endothelial cells and its induction by lipopolysaccharide. Cytokine 10: 199-205. (Pubitemid 28171874)
18. Strieter, R.M., S.L. Kunkel, and R.C. Bone. 1993. Role of tumor necrosis factor-alpha in disease states and inflammation. Critical Care Medicine 21: S447-S463. (Pubitemid 23304335)
19. Ozturk, H., Y. Yagmur, and H. Ozturk. 2008. The prognostic importance of serum IL-1beta, IL-6, IL-8 and TNF-alpha levels compared to trauma scoring systems for early mortality in children with blunt trauma. Pediatric Surgery International 24: 235-239.
20. Zedler, S., and E. Faist. 2006. The impact of endogenous triggers on trauma-associated inflammation. Current Opinion in Critical Care 12: 595-601. (Pubitemid 44673437)
21. Calandra, T., and R. Bucala. 1997. Macrophage migration inhibitory factor (MIF): A glucocorticoid counter-regulator within the immune system. Critical Reviews in Immunology 17: 77-88. (Pubitemid 27068808)
22. Calandra, T., J. Bernhagen, R.A. Mitchell, and R. Bucala. 1994. The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. Journal of Experimental Medicine 179: 1895-1902. (Pubitemid 24155670)
23. Bernhagen, J., R.A. Mitchell, T. Calandra, W. Voelter, A. Cerami, and R. Bucala. 1994. Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF). Biochemistry 33: 14144-14155. (Pubitemid 24382359)
24. Calandra, T., B. Echtenacher, D.L. Roy, J. Pugin, C.N. Metz, L. Hultner, D. Heumann, D. Mannel, R. Bucala, and M.P. Glauser. 2000. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nature Medicine 6: 164-170. (Pubitemid 30082360)
25. Bacher, M., A. Meinhardt, H.Y. Lan, W. Mu, C.N. Metz, J.A. Chesney, T.Calandra, D. Gemsa, T. Donnelly, R.C. Atkins, and R. Bucala. 1997. Migration inhibitory factor expression in experimentally induced endotoxemia. American Journal of Pathology 150: 235-246. (Pubitemid 27027113)
26. Emonts, M., F.C. Sweep, N. Grebenchtchikov, A. Geurts-Moespot, M. Knaup, A.L. Chanson, V. Erard, P. Renner, P.W. Hermans, J.A. Hazelzet, and T. Calandra. 2007. Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis. Clinical Infectious Diseases 44: 1321-1328. (Pubitemid 46717294)