Design, synthesis, and biological activity of novel Magmas inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3479-3482

  Jubinsky, Paul T ^a,b   Short, Mary K ^b   Ghanem, Mohmoud ^b   Das, Bhaskar C ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Chemical genetics; Guanidine pharmacophores; LRD limited; Magmas inhibitors; Mitochondrial protein import; Molecular modeling; Pam16; Rational design; Tim16

Indexed keywords

PROTEIN INHIBITOR; SMALL MOLECULE MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR SIGNALING MOLECULE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FLUOROMETRY; GROWTH INHIBITION; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; PREDICTION; SACCHAROMYCES CEREVISIAE;

CELL PROLIFERATION; DRUG DESIGN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; YEASTS;

EID: 79956157506     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.050     Document Type: Article

References (22)

1. P.T. Jubinsky, A. Messer, J. Bender, R.E. Morris, G.M. Ciraolo, D.P. Witte, R.G. Hawley, and M.K. Short Exp. Hematol. 29 2001 1392
2. P.T. Jubinsky, M.K. Short, G. Mutema, and D.P. Witte J. Histochem. Cytochem. 51 2003 585
3. J. Peng, C.H. Huang, M.K. Short, and P.T. Jubinsky In Silico Biol. 5 2005 251
4. Y. Li, J. Dudek, B. Guiard, N. Pfanner, P. Rehling, and W. Voos J. Biol. Chem. 279 2004 38047
5. P.R. D'Silva, B. Schilke, W. Walter, and E.A. Craig Proc. Natl. Acad. Sci. U.S.A. 102 2005 12419
6. A.E. Frazier, J. Dudek, B. Guiard, W. Voos, Y. Li, M. Lind, C. Meisinger, A. Geissler, A. Sickmann, H.E. Meyer, V. Bilanchone, M.G. Cumsky, K.N. Truscott, N. Pfanner, and P. Rehling Nat. Struct. Mol. Biol. 11 2004 226
7. D. Mokranjac, G. Bourenkov, K. Hell, W. Neupert, and M. Groll EMBO J. 25 2006 4675
8. C. Kozany, D. Mokranjac, M. Sichting, W. Neupert, and K. Hell Nat. Struct. Mol. Biol. 11 2004 234
9. P.T. Jubinsky, M.K. Short, G. Mutema, R.E. Morris, G.M. Ciraolo, and M. Li J. Mol. Histol. 36 2005 69
10. M.J. van de Vijver, Y.D. He, L.J. Van't Veer, H. Dai, A.A. Hart, D.W. Voskuil, G.J. Schreiber, J.L. Peterse, C. Roberts, M.J. Marton, M. Parrish, D. Atsma, A. Witteveen, A. Glas, L. Delahaye, T. van der Velde, H. Bartelink, S. Rodenhuis, E.T. Rutgers, S.H. Friend, and R.N. Bernards Engl. J. Med. 347 2002 1999
11. C. Desmedt, F. Piette, S. Loi, Y. Wang, F. Lallemand, B. Haibe-Kains, G. Viale, M. Delorenzi, Y. Zhang, M.S. d'Assignies, J. Bergh, R. Lidereau, P. Ellis, A.L. Harris, J.G. Klijn, J.A. Foekens, F. Cardoso, M.J. Piccart, M. Buyse, and C. Sotiriou Clin. Cancer Res. 13 2007 3207
12. F. Tagliati, E. Gentilin, M. Buratto, D. Mole, E.C. degli Uberti, and M.C. Zatelli Endocrinology 151 2010 4635
13. D. Sinha, N. Joshi, B. Chittoor, P. Samji, and P. D'Silva Human Mol. Genet. 19 2010 1248
14. S. Elsner, D. Simian, O. Iosefson, M. Marom, and A. Azem Int. J. Mol. Sci. 10 2009 2041
15. D.R. Shridhar, C.V. Reddy Sastry, O.P. Bansal, and P.P. Pulla Rao Synthesis 19 1981 2
16. F. Liu, T. Evans, and B.C. Das Tetrahedron Lett. 49 2008 1578
17. +) 326.2227; found: 326.2223.
18. J.D. Boeke, J. Trueheart, G. Natsoulis, and G.R. Fink Methods Enzymol. 154 1987 164
19. Totrov, M.; Abagyan, R. Proteins 1997, Suppl 1, 215.
20. A. Fernandez-Mateos, L. Mateos Buron, E.M. Martin de la Nava, and R. Rubio Gonzalez J. Org. Chem. 68 2003 3585
21. M. Rosenberger, and C. Neukom J. Org. Chem. 47 1982 1782
22. K.M. Waugh, K.D. Berlin, W.T. Ford, E.M. Holt, J.P. Carrol, P.R. Schomber, M.D. Thompson, and L.J. Schiff J. Med. Chem. 28 1985 116