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Volumn 7, Issue 5, 2011, Pages 657-668

Targeted therapy in refractory thyroid cancer: Current achievements and limitations

Author keywords

anaplastic thyroid cancer; differentiated thyroid cancer; drug resistance; medullary thyroid cancer; Phase II III trials; targeted therapy; tyrosine kinase inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; AXITINIB; B RAF KINASE; BMS 907351; BORTEZOMIB; CABOZANTINIB; COMBRETASTATIN A4 PHOSPHATE; EVEROLIMUS; LENALIDOMIDE; LENVATINIB; MOTESANIB; PACLITAXEL; PAZOPANIB; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; SELUMETINIB; SEMAXANIB; SORAFENIB; SUNITINIB; TEMSIROLIMUS; THALIDOMIDE; TIPIFARNIB; UNCLASSIFIED DRUG; VANDETANIB; VEMURAFENIB; XL 184;

EID: 79956147587     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.11.30     Document Type: Review
Times cited : (11)

References (71)
  • 1
    • 76249089855 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates
    • Edwards BK, Ward E, Kohler BA, et al.: Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116(3), 544-573 (2010).
    • (2010) Cancer , vol.116 , Issue.3 , pp. 544-573
    • Edwards, B.K.1    Ward, E.2    Kohler, B.A.3
  • 3
    • 70449370231 scopus 로고    scopus 로고
    • Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer
    • Cooper DS, Doherty GM, Haugen BR, et al.: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19(11), 1167-214 (2009).
    • (2009) Thyroid , vol.19 , Issue.11 , pp. 1167-214
    • Cooper, D.S.1    Doherty, G.M.2    Haugen, B.R.3
  • 7
    • 79956137560 scopus 로고    scopus 로고
    • Anaplastic thyroid cancer
    • Edition Nucléon, France
    • Schlumberger M, Pacini F: Anaplastic thyroid cancer. In: Thyroid Tumors. Edition Nucléon, France, 303-312 (2006).
    • (2006) Thyroid Tumors , pp. 303-312
    • Schlumberger, M.1    Pacini, F.2
  • 8
    • 56649105350 scopus 로고    scopus 로고
    • Molecular pathology of thyroid cancer: Diagnostic and clinical implications
    • Fagin JA, Mitsiades N: Molecular pathology of thyroid cancer: diagnostic and clinical implications. Best Pract. Res. Clin. Endocrinol. Metab. 22(6), 955-969 (2008).
    • (2008) Best Pract. Res. Clin. Endocrinol. Metab. , vol.22 , Issue.6 , pp. 955-969
    • Fagin, J.A.1    Mitsiades, N.2
  • 9
    • 75449083561 scopus 로고    scopus 로고
    • Molecular diagnostics and predictors in thyroid cancer
    • Nikiforova MN, Nikiforov YE: Molecular diagnostics and predictors in thyroid cancer. Thyroid 19(12), 1351-1361 (2009).
    • (2009) Thyroid , vol.19 , Issue.12 , pp. 1351-1361
    • Nikiforova, M.N.1    Nikiforov, Y.E.2
  • 11
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • Weinstein IB, Joe A: Oncogene addiction. Cancer Res. 68(9), 3077-3080 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.9 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 12
    • 30744455269 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in thyroid cancers
    • Lin JD, Chao TC: Vascular endothelial growth factor in thyroid cancers. Cancer Biother. Radiopharm. 20(6), 648-661 (2005).
    • (2005) Cancer Biother. Radiopharm. , vol.20 , Issue.6 , pp. 648-661
    • Lin, J.D.1    Chao, T.C.2
  • 13
    • 77955298957 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma
    • Capp C, Wajner SM, Siqueira DR, Brasil BA, Meurer L, Maia AL: Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma. Thyroid 20(8), 863-871 (2010).
    • (2010) Thyroid , vol.20 , Issue.8 , pp. 863-871
    • Capp, C.1    Wajner, S.M.2    Siqueira, D.R.3    Brasil, B.A.4    Meurer, L.5    Maia, A.L.6
  • 14
    • 28144454205 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor C in papillary thyroid carcinoma correlates with cervical lymph node metastases
    • DOI 10.1158/1078-0432.CCR-05-0646
    • Yu XM, Lo CY, Chan WF, Lam KY, Leung P, Luk JM: Increased expression of vascular endothelial growth factor C in papillary thyroid carcinoma correlates with cervical lymph node metastases. Clin. Cancer Res. 11(22), 8063-8069 (2005). (Pubitemid 41698749)
    • (2005) Clinical Cancer Research , vol.11 , Issue.22 , pp. 8063-8069
    • Yu, X.-M.1    Lo, C.-Y.2    Chan, W.-F.3    Lam, K.-Y.4    Leung, P.5    Luk, J.M.6
  • 18
    • 77950678272 scopus 로고    scopus 로고
    • Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy
    • Sierra JR, Cepero V, Giordano S: Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy. Mol. Cancer 9(75), 1-13 (2010).
    • (2010) Mol. Cancer , vol.9 , Issue.75 , pp. 1-13
    • Sierra, J.R.1    Cepero, V.2    Giordano, S.3
  • 21
    • 68949108390 scopus 로고    scopus 로고
    • Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
    • Schlumberger MJ, Elisei R, Bastholt L, et al.: Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J. Clin. Oncol. 27(23), 3794-3801 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.23 , pp. 3794-3801
    • Schlumberger, M.J.1    Elisei, R.2    Bastholt, L.3
  • 22
    • 77957366667 scopus 로고    scopus 로고
    • Biomarkers as predictors of response to treatment with motesanib in patients with progressive advanced thyroid cancer
    • Bass MB, Sherman SI, Schlumberger MJ, et al.: Biomarkers as predictors of response to treatment with motesanib in patients with progressive advanced thyroid cancer. J. Clin. Endocrinol. Metab. 95(11), 5018-5027 (2010).
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , Issue.11 , pp. 5018-5027
    • Bass, M.B.1    Sherman, S.I.2    Schlumberger, M.J.3
  • 23
    • 79956082085 scopus 로고    scopus 로고
    • Phase II study of sunitinib in refractory thyroid cancer
    • Chicago, IL, USA, 30 May-3 June 2008 (Abstract 6025)
    • Cohen EE, Needles BM, Cullen KJ, et al.: Phase II study of sunitinib in refractory thyroid cancer. Presented at: 2008 ASCO Annual Meeting. Chicago, IL, USA, 30 May-3 June 2008 (Abstract 6025).
    • 2008 ASCO Annual Meeting
    • Cohen, E.E.1    Needles, B.M.2    Cullen, K.J.3
  • 24
    • 79956094533 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in medullary thyroid cancer (MTC)
    • Chicago USA, 4-8 June 2010 (Abstract 5504)
    • De Souza JA, Busaidy N, Zimrin A, et al.: Phase II trial of sunitinib in medullary thyroid cancer (MTC). Presented at: 2010 ASCO Annual Meeting. Chicago, USA, 4-8 June 2010 (Abstract 5504).
    • 2010 ASCO Annual Meeting
    • De Souza, J.A.1    Busaidy, N.2    Zimrin, A.3
  • 25
    • 78049462514 scopus 로고    scopus 로고
    • Phase II study of sunitinib in FDG-PET positive, differentiated thyroid cancer and metastatic medullary carcinoma of thyroid with functional imaging correlation
    • Carr LL, Mankoff D, Goulart BH, et al.: Phase II study of sunitinib in FDG-PET positive, differentiated thyroid cancer and metastatic medullary carcinoma of thyroid with functional imaging correlation. Clin. Cancer Res. 16(21), 5260-5268 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.21 , pp. 5260-5268
    • Carr, L.L.1    Mankoff, D.2    Goulart, B.H.3
  • 26
    • 77649112149 scopus 로고    scopus 로고
    • Efficacy of sunitinib in advanced medullary thyroid carcinoma: Intermediate results of Phase II THYSU
    • Ravaud A, De La Fouchardiére C, Asselineau J, et al.: Efficacy of sunitinib in advanced medullary thyroid carcinoma: intermediate results of Phase II THYSU. Oncologist 15, 212-213 (2010).
    • (2010) Oncologist , vol.15 , pp. 212-213
    • Ravaud, A.1    De La Fouchardiére, C.2    Asselineau, J.3
  • 27
    • 11244327801 scopus 로고    scopus 로고
    • Identification of RET kinase inhibitors as potential new treatment for sporadic and inherited thyroid cancer
    • Carlomagno F, Santoro M: Identification of RET kinase inhibitors as potential new treatment for sporadic and inherited thyroid cancer. J. Chemother. 16, 49-51 (2004). (Pubitemid 40065281)
    • (2004) Journal of Chemotherapy , vol.16 , Issue.SUPPL. 4 , pp. 49-51
    • Carlomagno, F.1    Santoro, M.2
  • 28
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells SA Jr, Gosnell JE, Gagel RF, et al.: Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J. Clin. Oncol. 28(5), 767-772 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.5 , pp. 767-772
    • Wells Jr., S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 29
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R: Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J. Clin. Endocrinol. Metab. 95(6), 2664-2671 (2010).
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , Issue.6 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3    Vasselli, J.4    Haddad, R.5
  • 30
    • 79955712325 scopus 로고    scopus 로고
    • Vandetanib in locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind Phase III trial (ZETA)
    • Paris, France, 11-16 September
    • Wells SA, Robinson BG, Gagel RF, et al.: Vandetanib in locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind Phase III trial (ZETA). Presented at: 14th International Thyroid Congress. Oral Communication 021. Paris, France 11-16 September 2010.
    • (2010) 14th International Thyroid Congress. Oral Communication 021
    • Wells, S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 31
    • 79851508147 scopus 로고    scopus 로고
    • Vandetanib in locally advanced or metastatic differentiated thyroid cancer (papillary or follicular; DTC): A randomized, double-blind Phase II trial
    • Paris, France, 11-16 September
    • Leboulleux S, Bastholt L, Krause TM, et al.: Vandetanib in locally advanced or metastatic differentiated thyroid cancer (papillary or follicular; DTC): a randomized, double-blind Phase II trial. Presented at: 14th International Thyroid Congress. Oral Communication 023. Paris, France 11-16 September 2010.
    • (2010) 14th International Thyroid Congress. Oral Communication 023
    • Leboulleux, S.1    Bastholt, L.2    Krause, T.M.3
  • 32
    • 24944453855 scopus 로고    scopus 로고
    • Phase i trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • Rugo HS, Herbst RS, Liu G, et al.: Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J. Clin. Oncol. 23(24), 5474-5483 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.24 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3
  • 33
    • 50649095801 scopus 로고    scopus 로고
    • Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a Phase II study
    • Cohen EE, Rosen LS, Vokes EE, et al.: Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a Phase II study. J. Clin. Oncol. 26(29), 4708-4713 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.29 , pp. 4708-4713
    • Cohen, E.E.1    Rosen, L.S.2    Vokes, E.E.3
  • 34
    • 79956104365 scopus 로고    scopus 로고
    • Long-term results in a cohort of medullary thyroid cancer (MTC) patients (pts) in a Phase i study of XL-184 (BMS 907351), an oral inhibitor of MET, VEGFR2, and RET
    • Chicago, IL, USA, 4-8 June 2010 (Abstract 5502)
    • Kurzrock R, Cohen EE, Sherman SI, et al.: Long-term results in a cohort of medullary thyroid cancer (MTC) patients (pts) in a Phase I study of XL-184 (BMS 907351), an oral inhibitor of MET, VEGFR2, and RET. Presented at: 2010 ASCO Annual Meeting. Chicago, IL, USA, 4-8 June 2010 (Abstract 5502).
    • 2010 ASCO Annual Meeting
    • Kurzrock, R.1    Cohen, E.E.2    Sherman, S.I.3
  • 35
    • 50649095250 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in advanced thyroid cancer
    • Gupta-Abramson V, Troxel AB, Nellore A, et al.: Phase II trial of sorafenib in advanced thyroid cancer. J. Clin. Oncol. 26(29), 4714-4719 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.29 , pp. 4714-4719
    • Gupta-Abramson, V.1    Troxel, A.B.2    Nellore, A.3
  • 36
    • 63849265332 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in metastatic thyroid cancer
    • Kloos RT, Ringel MD, Knopp MV, et al.: Phase II trial of sorafenib in metastatic thyroid cancer. J. Clin. Oncol. 27(10), 1675-1684 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.10 , pp. 1675-1684
    • Kloos, R.T.1    Ringel, M.D.2    Knopp, M.V.3
  • 37
    • 72949106263 scopus 로고    scopus 로고
    • Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma
    • Hoftijzer H, Heemstra KA, Morreau H, et al.: Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma. Eur. J. Endocrinol. 161(6), 923-931 (2009).
    • (2009) Eur. J. Endocrinol. , vol.161 , Issue.6 , pp. 923-931
    • Hoftijzer, H.1    Heemstra, K.A.2    Morreau, H.3
  • 38
    • 77952468875 scopus 로고    scopus 로고
    • Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
    • Lam ET, Ringel MD, Kloos RT, et al.: Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. J. Clin. Oncol. 28(14), 2323-2330 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.14 , pp. 2323-2330
    • Lam, E.T.1    Ringel, M.D.2    Kloos, R.T.3
  • 39
    • 84891890676 scopus 로고    scopus 로고
    • Sorafenib in patients (pts) with advanced thyroid carcinoma (TC): A compassionate use program
    • Abstract 5590
    • Capdevila J, Iglesias L, Halperin I, et al.: Sorafenib in patients (pts) with advanced thyroid carcinoma (TC): a compassionate use program. J. Clin. Oncol. 28(Suppl. 15) (2010) (Abstract 5590).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.SUPPL. 15
    • Capdevila, J.1    Iglesias, L.2    Halperin, I.3
  • 40
    • 77957359933 scopus 로고    scopus 로고
    • Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: Results of a Phase 2 consortium study
    • Bible KC, Suman VJ, Molina JR, et al.: Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a Phase 2 consortium study. Lancet Oncol. 11(10), 962-972 (2010).
    • (2010) Lancet Oncol. , vol.11 , Issue.10 , pp. 962-972
    • Bible, K.C.1    Suman, V.J.2    Molina, J.R.3
  • 41
    • 67651246671 scopus 로고    scopus 로고
    • Phase i study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer
    • Abstract 9000
    • Flaherty K, Puzanov I, Sosman J, et al.: Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer. J. Clin. Oncol. 27(Suppl. 15) (2009) (Abstract 9000).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15
    • Flaherty, K.1    Puzanov, I.2    Sosman, J.3
  • 42
    • 77957969168 scopus 로고    scopus 로고
    • Phase II study and tissue correlative studies of AZD6244 (ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma (IRPTC) and papillary thyroid carcinoma (PTC) with follicular elements
    • Abstract 5536
    • Lucas AS, Cohen EE, Cohen RB, et al.: Phase II study and tissue correlative studies of AZD6244 (ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma (IRPTC) and papillary thyroid carcinoma (PTC) with follicular elements. J. Clin. Oncol. 28(Suppl. 15) (2010) (Abstract 5536).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.SUPPL. 15
    • Lucas, A.S.1    Cohen, E.E.2    Cohen, R.B.3
  • 43
    • 77952038495 scopus 로고    scopus 로고
    • Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signalling pathway inhibitors
    • Maitland ML, Bakris GL, Black HR, et al.: Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signalling pathway inhibitors. J. Natl Cancer Inst. 102(9), 596-604 (2010).
    • (2010) J. Natl Cancer Inst. , vol.102 , Issue.9 , pp. 596-604
    • Maitland, M.L.1    Bakris, G.L.2    Black, H.R.3
  • 44
    • 52949128348 scopus 로고    scopus 로고
    • Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib
    • Lacouture ME, Wu S, Robert C, et al.: Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib. Oncologist 13(9), 1001-1011 (2008).
    • (2008) Oncologist , vol.13 , Issue.9 , pp. 1001-1011
    • Lacouture, M.E.1    Wu, S.2    Robert, C.3
  • 45
    • 62649174250 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors and modifications of thyroid function tests: A review
    • Illouz F, Laboureau-Soares S, Dubois S, Rohmer V, Rodien P: Tyrosine kinase inhibitors and modifications of thyroid function tests: a review. Eur. J. Endocrinol. 160 (3), 331-336 (2009).
    • (2009) Eur. J. Endocrinol. , vol.160 , Issue.3 , pp. 331-336
    • Illouz, F.1    Laboureau-Soares, S.2    Dubois, S.3    Rohmer, V.4    Rodien, P.5
  • 46
    • 78149415046 scopus 로고    scopus 로고
    • Population pharmacokinetic/pharmacodynamic modeling for the time course of tumor shrinkage by motesanib in thyroid cancer patients
    • Lu JF, Claret L, Sutjandra L, et al.: Population pharmacokinetic/ pharmacodynamic modeling for the time course of tumor shrinkage by motesanib in thyroid cancer patients. Cancer Chemother. Pharmacol. 66(6), 1151-1158 (2010).
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , Issue.6 , pp. 1151-1158
    • Lu, J.F.1    Claret, L.2    Sutjandra, L.3
  • 47
    • 63749094012 scopus 로고    scopus 로고
    • Randomized Phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates
    • Fizazi K, Lipton A, Mariette X, et al.: Randomized Phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J. Clin. Oncol. 27(10), 1564-1571 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.10 , pp. 1564-1571
    • Fizazi, K.1    Lipton, A.2    Mariette, X.3
  • 49
    • 66749155964 scopus 로고    scopus 로고
    • Inhibition of Src with AZD0530 reveals the Src-Focal Adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer
    • Schweppe RE, Kerege AA, French JD, Sharma V, Grzywa RL, Haugen BR: Inhibition of Src with AZD0530 reveals the Src-Focal Adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer. J. Clin. Endocrinol. Metab. 94(6), 2199-2203 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , Issue.6 , pp. 2199-2203
    • Schweppe, R.E.1    Kerege, A.A.2    French, J.D.3    Sharma, V.4    Grzywa, R.L.5    Haugen, B.R.6
  • 51
    • 62349137638 scopus 로고    scopus 로고
    • A Phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome
    • Mooney CJ, Nagaiah G, Fu P, et al.: A Phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome. Thyroid 19(3), 233-240 (2009).
    • (2009) Thyroid , vol.19 , Issue.3 , pp. 233-240
    • Mooney, C.J.1    Nagaiah, G.2    Fu, P.3
  • 52
    • 49249127826 scopus 로고    scopus 로고
    • Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers
    • Liu Z, Hou P, Ji M, et al.: Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers. J. Clin. Endocrinol. Metab. 93(8), 3106-3116 (2008).
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , Issue.8 , pp. 3106-3116
    • Liu, Z.1    Hou, P.2    Ji, M.3
  • 54
    • 79956108653 scopus 로고    scopus 로고
    • Combination therapy with sunitinib and bortezomib in adult patients with radioiodine refractory thyroid cancer
    • Chicago, IL, USA, 4-8 June 2010 (Abstract 5589)
    • Harvey RD, Kauh JS, Ramalingam SS, et al.: Combination therapy with sunitinib and bortezomib in adult patients with radioiodine refractory thyroid cancer. Presented at: 2010 ASCO Annual Meeting. Chicago, IL, USA, 4-8 June 2010 (Abstract 5589).
    • 2010 ASCO Annual Meeting
    • Harvey, R.D.1    Kauh, J.S.2    Ramalingam, S.S.3
  • 55
    • 34548189195 scopus 로고    scopus 로고
    • Phase II trial of thalidomide for therapy of radioiodine-unresponsive and rapidly progressive thyroid carcinomas
    • DOI 10.1089/thy.2006.0289
    • Ain KB, Lee C, Williams KD: Phase II trial of thalidomide for therapy of radioiodine-unresponsive and rapidly progressive thyroid carcinomas. Thyroid 17(7), 663-670 (2007). (Pubitemid 47311556)
    • (2007) Thyroid , vol.17 , Issue.7 , pp. 663-670
    • Ain, K.B.1    Lee, C.2    Williams, K.D.3
  • 56
    • 79251499624 scopus 로고    scopus 로고
    • Phase II study of lenalidomide in distantly metastatic rapidly progressive and radioiodine-unresponsive thyroid carcinomas: Preliminary results
    • Chicago, IL, USA 30 May-3 June 2008 (Abstract 6027)
    • Ain KB, Lee C, Holbrook KM, Dziba JM, Williams KD: Phase II study of lenalidomide in distantly metastatic, rapidly progressive, and radioiodine-unresponsive thyroid carcinomas: preliminary results. Presented at: 2008 ASCO Annual Meeting. Chicago, IL, USA 30 May-3 June 2008 (Abstract 6027).
    • 2008 ASCO Annual Meeting
    • Ain, K.B.1    Lee, C.2    Holbrook, K.M.3    Dziba, J.M.4    Williams, K.D.5
  • 57
    • 77957942306 scopus 로고    scopus 로고
    • Phase i trial of combination sorafenib and tipifarnib: The experience in advanced differentiated thyroid cancer (DTC) and medullary thyroid cancer (MTC)
    • Abstract 5586
    • Cabanillas ME, Kurzrock R, Sherman SI: Phase I trial of combination sorafenib and tipifarnib: the experience in advanced differentiated thyroid cancer (DTC) and medullary thyroid cancer (MTC). J. Clin. Oncol. 28, (Suppl. 15) (2010) (Abstract 5586).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.SUPPL. 15
    • Cabanillas, M.E.1    Kurzrock, R.2    Sherman, S.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.