Assessment of adrenal suppression in children with asthma treated with inhaled corticosteroids: Use of dehydroepiandrosterone sulfate as a screening test

Annals of Allergy, Asthma and Immunology

Volumn 97, Issue 2, 2006, Pages 182-186

  Dorsey, Morna J ^a,b   Cohen, Laurie E ^a   Phipatanakul, Wanda ^a   Denufrio, Danielle ^a   Schneider, Lynda C ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b JOHNS HOPKINS ALL CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CORTICOSTEROID; PRASTERONE SULFATE; TETRACOSACTIDE;

ADRENAL SUPPRESSION; AGE; ARTICLE; ASTHMA; CHILD; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CORTICOSTEROID THERAPY; DIAGNOSTIC VALUE; DISEASE MARKER; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; GENDER; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; PRIORITY JOURNAL; PROVOCATION TEST; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 33747697119     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)60010-5     Document Type: Article

References (31)

1. National Heart, Lung, and Blood Institute. Asthma Statistics. Bethesda, MD: US Dept of Health and Human Services; 1999.
2. National Asthma Education and Practice Program. Guidelines for the diagnosis and management of asthma: update on selected topics-2002. J Allergy Clin Immunol. 2002;110(suppl 5): S141-S219.
3. Ekins-Daukes S, Simpson CR, Helms PJ, Taylor MW, McLay JS. Burden of corticosteroids in children with asthma in primary care: retrospective observational study. BMJ. 2002;324:1374.
4. Agertoft L, Pedersen S. Short-term knemometry and urine cortisol excretion in children treated with fluticasone propionate and budesonide: a dose response study. Eur Respir J. 1997;10:1507-1512.
5. Doull IJ, Freezer NJ, Holgate ST. Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate. Am J Respir Crit Care Med. 1995;151:1715-1719.
6. Allen DB. Systemic effects of intranasal steroids: an endocrinologist's perspective. J Allergy Clin Immunol. 2000;106(suppl 4):S179-S190.
7. Nye EJ, Grice JE, Hockings GI, et al. Adrenocorticotropin stimulation tests in patients with hypothalamic-pituitary disease: low dose, standard high dose and 8-h infusion tests, Clin Endocrinol (Oxf). 2001;55:625-633.
8. Agwu JC, Spoudeas H, Hindmarsh PC, Pringle PJ, Brook CG. Tests of adrenal insufficiency. Arch Dis Child. 1999;80:330-333.
9. Fitzgerald D, Van Asperen P, Mellis C, Honner M, Smith L, Ambler G, Fluticasone propionate 750 micrograms/day versus beclomethasone dipropionate 1500 micrograms/day: comparison of efficacy and adrenal function in paediatric asthma. Thorax. 1998;53:656-661.
10. Kannisto S, Korppi M, Remes K, Voutilainen R. Adrenal suppression, evaluated by a low dose adrenocorticotropin test, and growth in asthmatic children treated with inhaled steroids. J Clin Endocrinol Metab. 2000;85:652-657.
11. Broide J, Soferman R, Kivity S, et al. Low-dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled corticosteroids. J Clin Endocrinol Metab. 1995;80:1243-1246.
12. Kannisto S, Laatikainen A, Taivainen A, Savolainen K, Tukiainen H, Voutilainen R. Serum dehydroepiandrosterone sulfate concentration as an indicator of adrenocortical suppression during inhaled steroid therapy in adult asthmatic patients. Eur J Endocrinol. 2004;150:687-690.
13. Todd G, Dunlop K, McNaboe J, Ryan MF, Carson D, Shields MD. Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate. Lancet. 1996;348:27-29.
14. Weiner P, Berar-Yanay N, Davidovich A, Magadle R. Nocturnal cortisol secretion in asthmatic patients after inhalation of fluticasone propionate. Chest. 1999;116:931-934.
15. Wales D, Makker H, Kane J, et al. Systemic bioavailability and potency of high-dose inhaled corticosteroids: a comparison of four inhaler devices and three drugs in healthy adult volunteers. Chest. 1999;115:1278-1284.
16. Edsbacker S, Kane J. Differences in bioavailability of fluticasone propionate via Diskus and pMDI [abstract]. Am J Respir Crit Care Med. 1999;159:A118.
17. Ferguson AC, Spier S, Manjra A, Versteegh FG, Mark S, Zhang P. Efficacy and safety of high-dose inhaled steroids in children with asthma: a comparison of fluticasone propionate with budesonide. J Pediatr. 1999;134:422-427.
18. Rittmaster RS, Givner ML. Effect of daily and alternate day low dose prednisone on serum cortisol and adrenal androgens in hirsute women. J Clin Endocrinol Metab. 1988;67:400-403.
19. Kreitzer PM, Blethen SL, Festa RS, Chasalow FI. Dehydroepiandrosterone sulfate levels are not suppressible by glucocorticoids before adrenarche. J Clin Endocrinol Metab. 1989;69:1309-1311.
20. Kannisto S, Korppi M, Remes K, Voutilainen R. Serum dehydroepiandrosterone sulfate concentration as an indicator of adrenocortical suppression in asthmatic children treated with inhaled steroids. J Clin Endocrinol Metab. 2001;86:4908-4912.
21. Dunn PJ, Mahood CB, Speed JF, Jury DR. Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study. N Z Med J. 1984;97:805-808.
22. Smith BJ, Buxton JR, Dickeson J, Heller RF. Does beclomethasone dipropionate suppress dehydroepiandrosterone sulphate in postmenopausal women? Aust N Z J Med. 1994;24:396-401.
23. Wilson JD, Foster DW, Kronenberg HM, Larsen PR, eds. Williams' Textbook of Endocrinology. Philadelphia, PA: WB Saunders Co; 1998:547-565, 1461.
24. Dunlop KA, Carson DJ, Steen HJ, McGovern V, McNaboe J, Shields MD. Monitoring growth in asthmatic children treated with high dose inhaled glucocorticoids does not predict adrenal suppression. Arch Dis Child. 2004;89:713-716.
25. Drake AJ, Howells RJ, Shield JP, Prendiville A, Ward PS, Crowne EC, Symptomatic adrenal insufficiency presenting with hypoglycaemia in children with asthma receiving high dose inhaled fluticasone propionate. BMJ. 2002;324:1081-1082.
26. Dunlop KA, DJ Carson, MD Shields. Hypoglycemia due to adrenal suppression secondary to high-dose nebulized corticosteroid. Pediatr Pulmonol. 2002;34:85-86.
27. Kennedy MJ, Carpenter JM, Lozano RA, Castile RG. Impaired recovery of hypothalamic-pituitary-adrenal axis function and hypoglycemic seizures after high-dose inhaled corticosteroid therapy in a toddler. Ann Allergy Asthma Immunol. 2002;88:523-526.
28. Macdessi JS, Randell TL, Donaghue KC, Ambler GR, van Asperen PP, Mellis CM. Adrenal crises in children treated with high-dose inhaled corticosteroids for asthma. Med J Aust. 2003;178:214-216.
29. Patel L, Wales JK, Kibirige MS, Massarano AA, Couriel JM, Clayton PE. Symptomatic adrenal insufficiency during inhaled corticosteroid treatment. Arch Dis Child. 2001;85:330-334.
30. Todd GR, Acerini CL, Buck JJ, et al. Acute adrenal crisis in asthmatics treated with high-dose fluticasone propionate. Eur Respir J. 2002;19:1207-1209.
31. Wong JY, Zacharin MR, Hocking N, Robinson PJ. Growth and adrenal suppression in asthmatic children on moderate to high doses of fluticasone propionate. J Paediatr Child Health. 2002;38:59-62.