Increased CD64 expression on polymorphonuclear neutrophils indicates infectious complications following solid organ transplantation

Cytometry Part A

Volumn 79 A, Issue 6, 2011, Pages 446-460

  Grey, Daniel ^a   Sack, Ulrich ^a,b   Scholz, Markus ^a   Knaack, Heike ^a   Fricke, Stephan ^b   Oppel, Christoph ^a   Luderer, Daniel ^a   Fangmann, Josef ^c   Emmrich, Frank ^a,b   Kamprad, Manja ^a,b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^c OLGAHOSPITAL   (Germany)

Author keywords

Complication; Infection; PMN CD64; Rejection; Solid organ transplantation

Indexed keywords

BIOLOGICAL MARKER; FC RECEPTOR; HLA DR ANTIGEN;

ADULT; AGED; ARTICLE; BLOOD; FLOW CYTOMETRY; GERMANY; GRAFT REJECTION; HUMAN; IMMUNOLOGY; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LYMPHOCYTE COUNT; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MONOCYTE; NEUTROPHIL; OPPORTUNISTIC INFECTION; PANCREAS TRANSPLANTATION; PATHOLOGY; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION; PROGNOSIS; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; BIOLOGICAL MARKERS; FLOW CYTOMETRY; GERMANY; GRAFT REJECTION; HLA-DR ANTIGENS; HUMANS; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LYMPHOCYTE COUNT; MIDDLE AGED; MONOCYTES; NEUTROPHILS; OPPORTUNISTIC INFECTIONS; PANCREAS TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; RECEPTORS, IGG; SENSITIVITY AND SPECIFICITY;

EID: 79956126336     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.21049     Document Type: Article

References (74)

1. Viale P, Scudeller L. Infectious complications after renal transplantation. G Ital Nefrol 2004; 21(Suppl 26): 48-52.
2. Andersen CB. Acute kidney graft rejection morphology and immunology. APMIS Suppl 1997. 67. 1-35.
3. Henley KS, Lucey MR, Appelman HD, Baliga P, Brown KA, Burtch GD, Campbell DAJr., Ham JM, Merion RM, Turcotte JG. Biochemical and histopathological correlation in liver transplant: The first 180 days. Hepatology 1992; 16: 688-693.
4. Drachenberg CB, Odorico J, Demetris AJ, Arend L, Bajema IM, Bruijn JA, Cantarovich D, Cathro HP, Chapman J, Dimosthenous K, Fyfe-Kirschner B, Gaber L, Gaber O, Goldberg J, Honsová E, Iskandar SS, Klassen DK, Nankivell B, Papadimitriou JC, Racusen LC, Randhawa P, Reinholt FP, Renaudin K, Revelo PP, Ruiz P, Torrealba JR, Vazquez-Martul E, Voska L, Stratta R, Bartlett ST, Sutherland DE. Banff schema for grading pancreas allograft rejection: Working proposal by a multi-disciplinary international consensus panel. Am J Transplant 2008; 8: 1237-1249.
5. Ormonde DG, de Boer WB, Kierath A, Bell R, Shilkin KB, House AK, Jeffrey GP, Reed WD. Banff Schema for grading liver allograft rejection: Utility in clinical practice. Liver Transplant Surg 1999; 5: 261-268.
6. Racusen LC. The Banff schema and differential diagnosis of allograft dysfunction. Transplant Proc 2004; 36: 753-754.
7. Weimann A, Eisele RM, Pawellek S, Hippler-Benscheid M, Rüggeberg A, Cammann H, Radke C, Müller C, Klupp J, Sack U, Lun A. Diagnostic value of peripheral blood markers for acute rejection in liver transplanted-patients receiving anti IL-2R antibodies. J Lab Med 2008; 32: 148-157.
8. Ashton-Chess J, Giral M, Soulillou JP, Brouard S. Can immune monitoring help to minimize immunosuppression in kidney transplantation? Eur Soc Org Transplant 2009; 22: 110-119.
9. Reding R, Gras J, Truong DQ, Wieërs G, Latinne D. The immunological monitoring of alloreactive responses in liver transplant recipients: A review. Liver Transplant 2006; 12: 373-383.
10. Zuber J. What's new in immunological monitoring? Néphrol Thér 2008; 4: 3-7.
11. Hickman PE, Potter JM, Pesce AJ. Clinical chemistry and post-liver-transplant monitoring. Clin Chem 1997; 43: 1546-1554.
12. Rodrigo E, Arias M. A practical approach to immune monitoring in kidney transplantation. Minerva Urol Nefrol 2007; 59: 337-352.
13. Schlaf G, Altermann WW, Rothhoff A, Seliger B. Soluble CD30 serum level-An adequate marker for allograft rejection of solid organs? Histol Histopathol 2007; 22: 1269-1279.
14. Süsal C, Pelzl S, Simon T, Opelz G. Advances in Pre- and posttransplant immunologic testing in kidney transplantation. Transplant Proc 2004; 26: 29-34.
15. Böhmig GA, Exner M, Watschinger B, Regele H. Acute humoral renal allograft rejection. Curr Opin Urol 2002; 12: 95-99.
16. Grebe SO, Mueller TF. Immune monitoring in organ transplantation using neopterin. Curr Drug Metab 2002; 3: 189-202.
17. Hickman PE, Lynch SV, Potter JM, Walker NI, Strong RW, Clouston AD. Gamma glutamyl transferase as a marker of liver transplant rejection. Transplantation 1994; 57: 1278-1280.
18. Dalton RS, Webber JN, Pead P, Gibbs PJ, Sadek SA, Howell WM. Immunomonitoring of renal transplant recipients in the early posttransplant period by sequential analysis of chemokine and chemokine receptor gene expression in peripheral blood mononuclear cells. Transplant Proc 2005; 37: 747-751.
19. Gebauer BS, Hricik DE, Atallah A, Bryan K, Riley J, Tary-Lehmann M, Greenspan NS, Dejelo C, Boehm BO, Hering BJ, Heeger PS. Evolution of the enzyme-linked immunosorbent spot assay for post-transplant alloreactivity as a potentially useful immune monitoring tool. Am J Transplant 2002; 2: 857-866.
20. Gibbs PJ, Tan LC, Sadek SA, Howell WM. Quantitative detection of changes in cytokine gene expression in peripheral blood mononuclear cells correlates with and precedes acute rejection in renal transplant recipients. Transplant Immunol 2005; 14: 99-108.
21. Kotsch K, Mashreghi MF, Bold G, Tretow P, Beyer J, Matz M, Hoerstrup J, Pratschke J, Ding R, Suthanthiran M, Volk HD, Reinke P. Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection. Transplantation 2004; 77: 1866-1875.
22. Gerna G, Lilleri D. Monitoring transplant patients for human cytomegalovirus: Diagnostic update. Herpes 2006; 13: 4-11.
23. Holzinger C, Buxbaum P, Laczkovics A, Domanig E, Wolner E. Infections in organ transplantations. Zentralbl Chir 1990; 115: 1091-1099.
24. Cheadle WG, Mercer-Jones M, Heinzelmann M, Polk HCJr. Sepsis and septic complications in the surgical patient: Who is at risk? Shock 1996; 6(Suppl 1): 6-9.
25. Muller Kobold AC, Tulleken JE, Zijlstra JG, Sluiter W, Hermans J, Kallenberg CG, Tervaert JW. Leukocyte activation in sepsis: Correlations with disease state and mortality. Int Care Med 2000; 26: 883-892.
26. Reinke P, Volk HD. Diagnostic and predictive value of an immune monitoring program for complications after kidney transplantation. Urol Int 1992; 49: 69-75.
27. Kuse ER, Langefeld I, Jaeger K, Külpmann WR. Procalcitonin-A new diagnostic tool in complications following liver transplantation. Int Care Med 2000; 26(Suppl 2): 187-192.
28. Coelho MC, Tannuri U, Tannuri AC, Reingenheim C, Troster EJ. Is procalcitonin useful to differentiate rejection from bacterial infection in the early post-operative period of liver transplantation in children? Pediatr Transplant 2009; 13: 1004-1006.
29. Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: A systematic review and meta-analysis. Clin Inf Dis 2004; 39: 206-217.
30. Sponholz C, Sakr Y, Reinhart K, Brunkhorst F. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: A systematic review of the literature. Crit Care 2006; 10: R145.
31. van Leeuwen HJ, Voorbij HA. Procalcitonin concentrations in the diagnosis of acute inflammatory reactions. Ned Tijdschr Geneeskd 2002; 146: 55-59.
32. Davis BH, Bigelow NC, Curnutte JT, Ornvold K. Neutrophil CD64 expression: Potential diagnostic indicator of acute inflammation and therapeutic monitor of interferon-y therapy. Lab Hematol 1995; 1: 3-12.
33. Davis BH. Improved diagnostic approaches to infection/sepsis detection. Exp Rev Mol Diagn 2005; 5: 193-207.
34. Qureshi SS, Lewis SM, Gant VA, Treacher D, Davis BH, Brown KA. Increased distribution and expression of CD64 on blood polymorphnuclear cells from patients with the systemic inflammatory response syndrome (SIRS). Clin Exp Immunol 2001; 125: 258-265.
35. Bhandari V, Wang C, Rinder C, Rinder H. Hematologic Profile of sepsis in neonates: Neutrophil CD64 as a diagnostic marker. Pediatrics 2008; 121: 129-134.
36. Davis BH. Quantitaive neutrophil CD64 expression: Promissing diagnostic indicator of infection or systemic acute inflammatory response. Clin Immunol Newslett 1996; 16: 121-130.
37. Davis BH. Neutrophil CD64 is an improved indicator of infection or sepsis in emergency department patients. Arch Pathol Lab Med 2006; 130: 654-661.
38. Livaditi O, Kotanidou A, Psarra A, Dimopoulou I, Sotiropoulou C, Augustatou K, Papasteriades C, Armaganidis A, Roussos C, Orfanos SE, Douzinas EE. Neutrophil CD64 expression and serum IL-8: Sensitive early markers of severity and outcome in sepsis. Cytokine 2006; 36: 283-290.
39. Ng PC, Li G, Chui KM, Chu WC, Li K, Wong RP, Chik KW, Wong E, Fok TF. Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection. Pediatr Res 2004; 56: 796-803.
40. Nuutila J, Hohenthal U, Laitinen I, Kotilainen P, Rajamäki A, Nikoskelainen J, Lilius EM. Simultaneous quantitative analysis of FcγRI (CD64) expression on neutrophils and monocytes: A new, improved way to detect infections. J Immunol Methods 2007; 328: 189-200.
41. Layseca-Espinosa E, Perez-Gonzalez LF, Torres-Montes A, Baranda L, de la Fuente H, Rosenstein Y, Gonzalez-Amaro R. Expression of CD64 as a potential marker of neonatal sepsis. Pediatr Allergy Immunol 2002; 13: 319-327.
42. Lun A, Sack U. Monitoring of organ-transplanted patients, In: Sack U, Tarnok A, Rothe G, editors. Cellular Diagnostics. Basel: Karger; 2008. pp 558-579
43. Anett H, Manja K, Claudia W, Michael W, Johann H, Frank E, Josef F, Ulrich S. Natürliche Killerzellen und natürliche Killer-T-Zellen bei Nierentransplantation. J Lab Med 2008; 32: 140-147.
44. Metz CE. Basic principles of ROC analysis. Semin Nuclear Med 1978; 8: 283-298.
45. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: A fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39: 561-577.
46. Qin G, Hotilovac L. Comparison of non-parametric confidence intervals for the area under the ROC curve of a continuous-scale diagnostic test. Stat Methods Med Res 2008; 17: 207-221.
47. Davis BH. Neutrophil CD64 expression in infection and sepsis. CLI 2006; 10.
48. Ravetch JV, Lanier LL. Immune inhibitory receptors. Science 2000; 290: 84-89.
49. Nimmerjahn F, Bruhns P, Horiuchi K, Ravetch JV. FcgammaRIV: A novel FcR with distinct IgG subclass specificity. Immunity 2005; 23: 41-51.
50. Ernst LK, van de Winkel JG, Chiu IM, Anderson CL. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. J Biol Chem 1992; 267: 15692-15700.
51. Ernst LK, Duchemin AM, Miller KL, Anderson CL Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts. Mol Immunol 1998; 35: 943-954.
52. Flesch BK, Neppert J. Functions of the Fc Receptors for Immunoglobulin G. J Clin Lab Anal 2000; 14: 141-156.
53. Nimmerjahn F, Ravetch JV. Fcgamma receptors: Old friends and new family members. Immunity 2006; 24: 19-28.
54. Ravetch JV. Fc receptors. In: Paul WE, editor. Fundamental Immunology. Philadelphia: Lippincott-Raven; 2003. pp 685-700.
55. Perussia B, Dayton ET, Lazarus R, Fanning V, Trinchieri G. Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells. J Exp Med 1983; 158: 1092-1113.
56. Repp R, Valerius T, Sendler A, Gramatzki M, Iro H, Kalden JR, Platzer E. Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor. Blood 1991; 78: 885-889.
57. Akerley WLIII, Guyre PM, Davis BH. Neutrophil activation through high-affinity Fc gamma receptor using a monomeric antibody with unique properties. Blood 1991; 77: 607-615.
58. Ng PC, Li K, Wong RP, Chui KM, Wong E, Fok TF. Neutrophil CD64 expression: A sensitive diagnostic marker for late-onset nosocomial infection in very low birthweight infants. Pediatr Res 2002; 51: 296-303.
59. Fischer G, Schneider EM, L Moldawer LL, Karcher C, Barth E, Suger-Wiedeck H, Georgieff M, Weiss M. CD64 surface expression on neutrophils is transiently upregulated in patients with septic shock. Intensive Care Med 2001; 27: 1848-1852.
60. Fjaertoft G, Håkansson L, Ewald U, Foucard T, Venge P. Neutrophils from term and preterm newborn infants express the high affinity Fcgamma-receptor I (CD64) during bacterial infections. Pediatr Res 1999; 45: 871-876.
61. van der Meer W, Pickkers P, Scott CS, van der Hoeven JG, Gunnewiek JK. Hematological indices, inflammatory markers and neutrophil CD64 expression: Comparative trends during experimental human endotoxemia. J Endotoxin Res 2007; 13: 94-100.
62. Keh D, Boehnke T, Weber-Cartens S, Schulz C, Ahlers O, Bercker S, Volk HD, Doecke WD, Falke KJ, Gerlach H. Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: A double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 2003; 167: 512-520.
63. Song GW, Lee SG, Park KM, Hwang S, Kim KH, Ahn CS, Moon DB, Ha TY. Clinical usefulness of serum C-reactive protein in living donor liver transplantation. Hepatogastroenterology 2008; 55: 164-168.
64. Reek C, Conrad S, Tenschert W, Huland H. Do serum C-reactive protein measurements help to discriminate episodes of renal dysfunction in patients after renal transplantation? Clin Chim Acta 2001; 310: 57-61.
65. Sezer S, Akcay A, Ozdemir FN, Kulah E, Arat Z, Haberal M. Post-transplant C-reactive protein monitoring can predict chronic allograft nephropathy. Clin Transplant 2004; 18: 722-725.
66. van Ree RM, Oterdoom LH, de Vries AP, Gansevoort RT, van der Heide JJ, van Son WJ, Ploeg RJ, de Jong PE, Gans RO, Bakker SJ. Elevated levels of C-reactive protein independently predict accelerated deterioration of graft function in renal transplant recipients. Nephrol Dial Transplant 2007; 22: 246-53.
67. Their M, Rönnholm K, Sairanen H, Holmberg C, Jalanko H. Serum C-reactive protein in pediatric kidney and liver transplant patients. Pediatr Transplant. 2002; 6: 153-160.
68. Haveman JW, van den Berg AP, van den Berk JM, Mesander G, Slooff MJ, de Leij LH, The TH. Low HLA-DR expression on peripheral blood monocytes predicts bacterial sepsis after liver transplantation: Relation with Prednisolone intake. Transplant Infect Dis 1999; 1: 146-152.
69. Daar AS, Morris PJ, Oliver DO. Leucocytosis is not a manifestation of rejection. Br Med J 1977; 2: 1570-1571.
70. Bastl CP, Hendler ED, Finkelstein FO. Leukocyte responses to acute renal transplant rejection. Clin Nephrol 1975; 4: 228-233.
71. Kiparski A, Frei D, Fierz W, Frei G, Uhlschmid G, Largiader F, Binswanger U. The effect of rejection crises and immunosuppressive therapy on the lymphocyte subpopulations of patients after kidney transplantation. Klin Wochenschr 1990; 68: 408-414.
72. Kreijveld E, Koenen HJ, van Cranenbroek B, van Rijssen E, Joosten I, Hilbrands LB. Immunological monitoring of renal transplant recipients to predict acute allograft rejection following the discontinuation of tacrolimus. PLoS One 2008; 3: e2711.
73. Davis BH, Bigelow NC. Comparison of neutrophil CD64 expression, manual myeloid immaturity counts, and automated hematology analyzer flags as indicators of infection or sepsis. Lab Hematol 2005; 11: 137-147.
74. Roussel M, Benard C, Ly-Sunnaram B, Fest T. Refining the white blood cell differential: The first flow cytometry routine application. Cytometry A. 2010; 77A: 552-563.