Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain

Journal of Experimental Medicine

Volumn 208, Issue 5, 2011, Pages 937-948

  Artegiani, Benedetta ^a,b   Lindemann, Dirk ^a   Calegari, Federico ^a,b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; HIPPOCAMPUS; IN VIVO STUDY; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL EXPANSION;

ANIMALS; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; GENE EXPRESSION REGULATION; HELA CELLS; HIPPOCAMPUS; HUMANS; MICE; NEURAL STEM CELLS; NEUROGENESIS;

EID: 79956125698     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20102167     Document Type: Article

References (36)

1. Arai, Y., J.N. Pulvers, C. Haffner, B. Schilling, I. Nüsslein, F. Calegari, and W.B. Huttner. 2011. Neural stem and progenitor cells shorten S-phase on commitment to neuron production. Nat Commun. 2:154.
2. Calegari, F., W. Haubensak, C. Haffner, and W.B. Huttner. 2005. Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development. J. Neurosci. 25:6533-6538.
3. Cameron, H.A., and R.D. McKay. 2001. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 435:406-417.
4. de Felipe, P., G.A. Luke, L.E. Hughes, D. Gani, C. Halpin, and M.D. Ryan. 2006. E unum pluribus: multiple proteins from a self-processing polyprotein. Trends Biotechnol. 24:68-75.
5. Deng, W., J.B. Aimone, and F.H. Gage. 2010. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat. Rev. Neurosci. 11:339-350.
6. Drapeau, E., and D. Nora Abrous. 2008. Stem cell review series: role of neurogenesis in age-related memory disorders. Aging Cell. 7:569-589.
7. Goldman, S. 2005. Stem and progenitor cell-based therapy of the human central nervous system. Nat. Biotechnol. 23:862-871.
8. Hayes, N.L., and R.S. Nowakowski. 2002. Dynamics of cell proliferation in the adult dentate gyrus of two inbred strains of mice. Brain Res. Dev. Brain Res. 134:77-85.
9. Hevner, R.F., R.D. Hodge, R.A. Daza, and C. Englund. 2006. Transcription factors in glutamatergic neurogenesis: conserved programs in neocortex, cerebellum, and adult hippocampus. Neurosci. Res. 55:223-233.
10. Hodge, R.D., T.D. Kowalczyk, S.A. Wolf, J.M. Encinas, C. Rippey, G. Enikolopov, G. Kempermann, and R.F. Hevner. 2008. Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output. J. Neurosci. 28:3707-3717.
11. Imayoshi, I., M. Sakamoto, T. Ohtsuka, K. Takao, T. Miyakawa, M. Yamaguchi, K. Mori, T. Ikeda, S. Itohara, and R. Kageyama. 2008. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat. Neurosci. 11:1153-1161.
12. Kempermann, G. 2008. The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for? Trends Neurosci. 31:163-169.
13. Kempermann, G., D. Gast, and F.H. Gage. 2002. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann. Neurol. 52:135-143.
14. Kempermann, G., S. Jessberger, B. Steiner, and G. Kronenberg. 2004. Milestones of neuronal development in the adult hippocampus. Trends Neurosci. 27:447-452.
15. Kriegstein, A., and A. Alvarez-Buylla. 2009. The glial nature of embryonic and adult neural stem cells. Annu. Rev. Neurosci. 32:149-184.
16. Lange, C., and F. Calegari. 2010. Cdks and cyclins link G1 length and differentiation of embryonic, neural and hematopoietic stem cells. Cell Cycle. 9:1893-1900.
17. Lange, C., W.B. Huttner, and F. Calegari. 2009. Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors. Cell Stem Cell. 5:320-331.
18. Lie, D.C., S.A. Colamarino, H.J. Song, L. Désiré, H. Mira, A. Consiglio, E.S. Lein, S. Jessberger, H. Lansford, A.R. Dearie, and F.H. Gage. 2005. Wnt signalling regulates adult hippocampal neurogenesis. Nature. 437:1370-1375.
19. Lindvall, O., and Z. Kokaia. 2006. Stem cells for the treatment of neurological disorders. Nature. 441:1094-1096.
20. Lugert, S., O. Basak, P. Knuckles, U. Haussler, K. Fabel, M. Götz, C.A. Haas, G. Kempermann, V. Taylor, and C. Giachino. 2010. Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell. 6:445-456.
21. Mochizuki, H., J.P. Schwartz, K. Tanaka, R.O. Brady, and J. Reiser. 1998. High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells. J. Virol. 72:8873-8883.
22. Orford, K.W., and D.T. Scadden. 2008. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat. Rev. Genet. 9:115-128.
23. Pietschmann, T., M. Heinkelein, M. Heldmann, H. Zentgraf, A. Rethwilm, and D. Lindemann. 1999. Foamy virus capsids require the cognate envelope protein for particle export. J. Virol. 73:2613-2621.
24. Pilaz, L.J., D. Patti, G. Marcy, E. Ollier, S. Pfister, R.J. Douglas, M. Betizeau, E. Gautier, V. Cortay, N. Doerflinger, et al. 2009. Forced G1-phase reduction alters mode of division, neuron number, and laminar phenotype in the cerebral cortex. Proc. Natl. Acad. Sci. USA. 106:21924-21929.
25. Salomoni, P., and F. Calegari. 2010. Cell cycle control of mammalian neural stem cells: putting a speed limit on G1. Trends Cell Biol. 20:233-243.
26. Seri, B., J.M. García-Verdugo, L. Collado-Morente, B.S. McEwen, and A. Alvarez-Buylla. 2004. Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus. J. Comp. Neurol. 478:359-378.
27. Shen, Q., Y. Wang, E. Kokovay, G. Lin, S.M. Chuang, S.K. Goderie, B. Roysam, and S. Temple. 2008. Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell. 3:289-300.
28. Singh, A.M., and S. Dalton. 2009. The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell. 5:141-149.
29. Suh, H., A. Consiglio, J. Ray, T. Sawai, K.A. D'Amour, and F.H. Gage. 2007. In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell. 1:515-528.
30. Tang, W., I. Ehrlich, S.B. Wolff, A.M. Michalski, S. Wölfl, M.T. Hasan, A. Lüthi, and R. Sprengel. 2009. Faithful expression of multiple proteins via 2Apeptide self-processing: a versatile and reliable method for manipulating brain circuits. J. Neurosci. 29:8621-8629.
31. Tavazoie, M., L. Van der Veken, V. Silva-Vargas, M. Louissaint, L. Colonna, B. Zaidi, J.M. Garcia-Verdugo, and F. Doetsch. 2008. A specializedvascular niche for adult neural stem cells. Cell Stem Cell. 3:279-288.
32. van Praag, H., A.F. Schinder, B.R. Christie, N. Toni, T.D. Palmer, and F.H. Gage. 2002. Functional neurogenesis in the adult hippocampus. Nature. 415:1030-1034.
33. Zarkowska, T., and S. Mittnacht. 1997. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272:12738-12746.
34. Zhang, R.L., Z.G. Zhang, M. Lu, Y. Wang, J.J. Yang, and M. Chopp. 2006. Reduction of the cell cycle length by decreasing G1 phase and cell cycle reentry expand neuronal progenitor cells in the subventricular zone of adult rat after stroke. J. Cereb. Blood Flow Metab. 26:857-863.
35. Zhang, R.L., Z.G. Zhang, C. Roberts, Y. LeTourneau, M. Lu, L. Zhang, Y. Wang, and M. Chopp. 2008. Lengthening the G(1) phase of neural progenitor cells is concurrent with an increase of symmetric neuron generating division after stroke. J. Cereb. Blood Flow Metab. 28:602-611.
36. Zhao, C., W. Deng, and F.H. Gage. 2008. Mechanisms and functional implications of adult neurogenesis. Cell. 132:645-660.