The Interplay of Genetics, Exercise, and Nutrition in Polysaccharide Storage Myopathy

Journal of Equine Veterinary Science

Volumn 31, Issue 5-6, 2011, Pages 205-210

  Valberg, Stephanie J ^a   McCue, Molly E ^a   Mickelson, Jim R ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Glycogen; Glycogenosis; Horse; Rhabdomyolysis; Tying up

Indexed keywords

EQUIDAE;

EID: 79956123150     PISSN: 07370806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jevs.2011.03.001     Document Type: Article

References (38)

1. Valberg S.J. Diseases of muscle. Large animal internal medicine 2002, 1272-1273. Mosby, St Louis, MO. B.P. Smith (Ed.).
2. Valberg S.J., Cardinet G.H., Carlson G.P., DiMauro S. Polysaccharide storage myopathy associated with recurrent exertional rhabdomyolysis in horses. Neuromuscul Disord 1992, 2:351-359.
3. Carlström B. Uber die atiologie und pathogenese der kreuzlahme des pferdes (Haemaglobinaemia paralytica). Scand Arch 1932, 62:1-62.
4. Valentine B.A., Cooper B.J. Incidence of polysaccharide storage myopathy: necropsy study of 225 horses. Vet Pathol 2005, 42:823-827.
5. Valentine B.A., Hintz H.F., Freels K.M., Reynolds A.J., Thompson K.N. Dietary control of exertional rhabdomyolysis in horses. J Am Vet Med Assoc 1998, 212:1588-1593.
6. Valentine B.A., Van Saun R.J., Thompson K.N., Hintz H.F. Role of dietary carbohydrate and fat in horses with equine polysaccharide storage myopathy. J Am Vet Med Assoc 2001, 219:1537-1544.
7. Annandale E.J., Valberg S.J., Mickelson J.R., Seaquist E.R. Insulin sensitivity and skeletal muscle glucose transport in horses with equine polysaccharide storage myopathy. Neuromuscul Disord 2004, 14:666-674.
8. Firshman A.M., Valberg S.J., Bender J.B., Annandale E.J., Hayden D.W. Comparison of histopathologic criteria and skeletal muscle fixation techniques for the diagnosis of polysaccharide storage myopathy in horses. Vet Pathol 2006, 43:257-269.
9. Valentine B.A., McDonough S.P., Chang Y.F., Vonderchek A.J. Polysaccharide storage myopathy in Morgan, Arabian, and Standardbred related horses and Welsh-cross ponies. Vet Pathol 2000, 37:193-196.
10. McCue M.E., Valberg S.J., Miller M.B., Wade C., DiMauro S., Akman H.O., et al. Glycogen synthase (GYS1) mutation causes a novel skeletal muscle glycogenosis. Genomics 2008, 91:458-466.
11. McCue M.E., Ribeiro W.P., Valberg S.J. Prevalence of polysaccharide storage myopathy in horses with neuromuscular disorders. Equine Vet J Suppl 2006, 36:340-344.
12. McCue M.E., Armien A.G., Lucio M., Mickelson J.R., Valberg S.J. Comparative skeletal muscle histopathologic and ultrastructural features in two forms of polysaccharide storage myopathy in horses. Vet Pathol 2009, 46:1281-1291.
13. Firshman A.M., Valberg S.J., Bender J.B., Finno C.J. Epidemiologic characteristics and management of polysaccharide storage myopathy in Quarter Horses. Am J Vet Res 2003, 64:1319-1327.
14. Firshman A.M., Baird J.D., Valberg S.J. Prevalences and clinical signs of polysaccharide storage myopathy and shivers in Belgian draft horses. J Am Vet Med Assoc 2005, 227:1958-1964.
15. Sprayberry K.A., Madigan J., Lecouteur R.A., Valentine B.A. Renal failure, laminitis, and colitis following severe rhabdomyolysis in a draft horse-cross with polysaccharide storage myopathy. Can Vet J 1998, 39:500-503.
16. De La Corte F.D., Valberg S.J., MacLeay J.M., Mickelson J.R. Developmental onset of polysaccharide storage myopathy in 4 Quarter Horse foals. J Vet Intern Med 2002, 16:581-587.
17. Valberg S.J., Geyer C., Sorum S.A., Cardinet G.H. Familial basis of exertional rhabdomyolysis in quarter horse-related breeds. Am J Vet Res 1996, 57:286-290.
18. Essen-Gustavsson B., Gottlieb-Vedi M., Lindholm A. Muscle adenine nucleotide degradation during submaximal treadmill exercise to fatigue. Equine Vet J Suppl 1999, 30:298-302.
19. Essen-Gustavsson B., Roneus N., Poso A.R. Metabolic response in skeletal muscle fibers of Standardbred trotters after racing. Comp Biochem Physiol B Biochem Mol Biol 1997, 117:431-436.
20. Annandale E.J., Valberg S.J., Essen-Gustavsson B. Effects of submaximal exercise on adenine nucleotide concentrations in skeletal muscle fibers of horses with polysaccharide storage myopathy. Am J Vet Res 2005, 66:839-845.
21. DiMauro S., Tsujino S., Shanske S., Rowland L.P. Biochemistry and molecular genetics of human glycogenoses: an overview. Muscle Nerve 1995, 3:S10-S17.
22. Valberg S.J., Townsend D., Mickelson J.R. Skeletal muscle glycolytic capacity and phosphofructokinase regulation in horses with polysaccharide storage myopathy. Am J Vet Res 1998, 59:782-785.
23. Valberg S.J., MacLeay J.M., Billstrom J.A., Hower-Moritz M.A., Mickelson J.R. Skeletal muscle metabolic response to exercise in horses with 'tying-up' due to polysaccharide storage myopathy. Equine Vet J 1999, 31:43-47.
24. De La Corte F.D., Valberg S.J., Mickelson J.R., Hower-Moritz M. Blood glucose clearance after feeding and exercise in polysaccharide storage myopathy. Equine Vet J Suppl 1999, 30:324-328.
25. Firshman A.M., Valberg S.J., Baird J.D., Hunt L., DiMauro S. Insulin sensitivity in Belgian horses with polysaccharide storage myopathy. Am J Vet Res 2008, 69:818-823.
26. Brojer J.T., Essen-Gustavsson B., Annandale E.J., Valberg S.J. Proglycogen, macroglycogen, glucose, and glucose-6-phosphate concentrations in skeletal muscles of horses with polysaccharide storage myopathy performing light exercise. Am J Vet Res 2006, 67:1589-1594.
27. Dranchak P.K., Leiper F.C., Valberg S.J., Piercy R.J., Carling D., McCue M.E., et al. Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter Horses. Am J Vet Res 2007, 68:1079-1084.
28. Ribeiro W.P., Valberg S.J., Pagan J.D., Gustavsson B.E. The effect of varying dietary starch and fat content on serum creatine kinase activity and substrate availability in equine polysaccharide storage myopathy. J Vet Intern Med 2004, 18:887-894.
29. Borgia L.A., Valberg S.J., McCue M.E., Pagan J.D., Roe C.R. Effect of dietary fats with odd or even numbers of carbon atoms on metabolic response and muscle damage with exercise in Quarter Horse-type horses with type 1 polysaccharide storage myopathy. Am J Vet Res 2010, 71:326-336.
30. Borgia L, Valberg S, McCue M, Watts K, Pagan J. Glycaemic and insulinaemic responses to feeding hay with different non-structural carbohydrate content in control and polysaccharide storage myopathy-affected horses. J Anim Physiol Anim Nutr (Berl) (in press).
31. Baird J.D., Valberg S.J., Anderson S.M., McCue M.E., Mickelson J.R. Presence of the glycogen synthase 1 (GYS1) mutation causing type 1 polysaccharide storage myopathy in continental European draught horse breeds. Vet Rec 2010, 167:781-784.
32. Herszberg B., McCue M.E., Larcher T., Mata X., Vaiman A., Chaffaux S., et al. A GYS1 gene mutation is highly associated with polysaccharide storage myopathy in Cob Normand draught horses. Anim Genet 2008, 40:94-96.
33. McCue M.E., Anderson S.M., Valberg S.J., Piercy R.J., Barakzai S.Z., Binns M.M., et al. Estimated prevalence of the type 1 Polysaccharide Storage Myopathy mutation in selected North American and European breeds. Anim Genet 2010, 41(Suppl 2):145-149.
34. McGowan C.M., Menzies-Gow N.J., McDiarmid A.M., Patterson-Kane J.C. Four cases of equine polysaccharide storage myopathy in the United Kingdom. Vet Rec 2003, 152:109-112.
35. Stanley R.L., McCue M.E., Valberg S.J., Mickelson J.R., Mayhew I.G., McGowan C., et al. A glycogen synthase 1 mutation associated with equine polysaccharide storage myopathy and exertional rhabdomyolysis occurs in a variety of UK breeds. Equine Vet J 2009, 41:597-601.
36. McCue M.E., Valberg S.J. Estimated prevalence of polysaccharide storage myopathy among overtly healthy Quarter Horses in the United States. Am J Vet Res 2007, 231:746-750.
37. Tryon R.C., Penedo M.C., McCue M.E., Valberg S.J., Mickelson J.R., Famula T.R., et al. Evaluation of allele frequencies of inherited disease genes in subgroups of American Quarter Horses. J Am Vet Med Assoc 2009, 234:120-125.
38. Ruderman N.B., Saha A.K., Vavvas D., Witters L.A. Malonyl-CoA, fuel sensing, and insulin 551 resistance. Am J Physiol Endocrinol Metab 1999, 276:E1-E18.