Palladium-catalyzed hydrofunctionalization of vinyl phenol derivatives with heteroaromatics

Organic Letters

Volumn 13, Issue 10, 2011, Pages 2774-2777

  Pathak, Tejas P ^a   Sigman, Matthew S ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCYCLIC COMPOUND; PALLADIUM; PHENOL DERIVATIVE; PYRROLE DERIVATIVE; VINYL DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

CATALYSIS; HETEROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; PALLADIUM; PHENOLS; PYRROLES; VINYL COMPOUNDS;

EID: 79956091065     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol200913r     Document Type: Article

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37. While Brönsted acid catalysis is unlikely under the basic reaction conditions, it should be noted that the use of TsOH (20 mol %) at 80 °C does promote this reaction to give 72% yield of compound 2a. However, acid-sensitive nucleophiles such as furans and enamines are not compatible under these acidic conditions.